Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer
E3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human <i>MARCH5</i> gene. The main objective of this study was to visualize the prognosis of <i>MARCH5</i> in breast cancer and to determine the relationship be...
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MDPI AG
2021-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/10/1329 |
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| author | Pei-Yi Chu Yen-Dun Tony Tzeng Yi-Han Chiu Hung-Yu Lin Chen-Hsin Kuo Ming-Feng Hou Chia-Jung Li |
| author_facet | Pei-Yi Chu Yen-Dun Tony Tzeng Yi-Han Chiu Hung-Yu Lin Chen-Hsin Kuo Ming-Feng Hou Chia-Jung Li |
| author_sort | Pei-Yi Chu |
| collection | DOAJ |
| description | E3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human <i>MARCH5</i> gene. The main objective of this study was to visualize the prognosis of <i>MARCH5</i> in breast cancer and to determine the relationship between <i>MARCH5</i> expression and tumor immunity. MARCH5 expression was significantly higher in several cancers, including breast cancer (BRCA), compared with corresponding normal tissues. Not only was high <i>MARCH5</i> expression associated with poorer overall survival, but also <i>MARCH5</i> expression was positively correlated with the number of tumor-infiltrating immune cells in BRCA malignant tissues. Furthermore, <i>MARCH5</i> expression showed a strong correlation with various immune markers of BRCA, suggesting its role in regulating tumor immunity. MARCH5 is a useful prognostic biomarker in several cancers, and its expression is highly correlated with tumor immune cell infiltration, and increased <i>MARCH5</i> expression may serve as a new biomarker for BRCA diagnosis and prognosis. |
| first_indexed | 2024-03-10T06:43:10Z |
| format | Article |
| id | doaj.art-2898110e01e240689e5f88439edc521f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:43:10Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-2898110e01e240689e5f88439edc521f2023-11-22T17:30:10ZengMDPI AGBiomedicines2227-90592021-09-01910132910.3390/biomedicines9101329Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast CancerPei-Yi Chu0Yen-Dun Tony Tzeng1Yi-Han Chiu2Hung-Yu Lin3Chen-Hsin Kuo4Ming-Feng Hou5Chia-Jung Li6College of Medicine, National Chung Hsing University, Taichung 402, TaiwanDepartment of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Microbiology, Soochow University, Taipei 111, TaiwanResearch Assistant Center, Show Chwan Memorial Hospital, Changhua 500, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDivision of Breast Surgery, Department of Surgery, Center for Cancer Research, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung 807, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanE3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human <i>MARCH5</i> gene. The main objective of this study was to visualize the prognosis of <i>MARCH5</i> in breast cancer and to determine the relationship between <i>MARCH5</i> expression and tumor immunity. MARCH5 expression was significantly higher in several cancers, including breast cancer (BRCA), compared with corresponding normal tissues. Not only was high <i>MARCH5</i> expression associated with poorer overall survival, but also <i>MARCH5</i> expression was positively correlated with the number of tumor-infiltrating immune cells in BRCA malignant tissues. Furthermore, <i>MARCH5</i> expression showed a strong correlation with various immune markers of BRCA, suggesting its role in regulating tumor immunity. MARCH5 is a useful prognostic biomarker in several cancers, and its expression is highly correlated with tumor immune cell infiltration, and increased <i>MARCH5</i> expression may serve as a new biomarker for BRCA diagnosis and prognosis.https://www.mdpi.com/2227-9059/9/10/1329multi-omicsMARCH5immune infiltrationprognosis |
| spellingShingle | Pei-Yi Chu Yen-Dun Tony Tzeng Yi-Han Chiu Hung-Yu Lin Chen-Hsin Kuo Ming-Feng Hou Chia-Jung Li Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer Biomedicines multi-omics MARCH5 immune infiltration prognosis |
| title | Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer |
| title_full | Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer |
| title_fullStr | Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer |
| title_full_unstemmed | Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer |
| title_short | Multi-Omics Reveals the Immunological Role and Prognostic Potential of Mitochondrial Ubiquitin Ligase MARCH5 in Human Breast Cancer |
| title_sort | multi omics reveals the immunological role and prognostic potential of mitochondrial ubiquitin ligase march5 in human breast cancer |
| topic | multi-omics MARCH5 immune infiltration prognosis |
| url | https://www.mdpi.com/2227-9059/9/10/1329 |
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