Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema

Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema

Abstract Secondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD. We identified the loss of APLN expression i...

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Bibliographic Details
Main Authors: Justine Creff, Asalaa Lamaa, Emeline Benuzzi, Elisa Balzan, Francoise Pujol, Tangra Draia-Nicolau, Manon Nougué, Lena Verdu, Florent Morfoisse, Eric Lacazette, Philippe Valet, Benoit Chaput, Fabian Gross, Regis Gayon, Pascale Bouillé, Julie Malloizel-Delaunay, Alessandra Bura-Rivière, Anne-Catherine Prats, Barbara Garmy-Susini
Format: Article
Language:English
Published: Springer Nature 2024-01-01
Series:EMBO Molecular Medicine
Subjects:
lymphedema
Apelin
VEGF-C
mRNA
Collector
Online Access:https://doi.org/10.1038/s44321-023-00017-7

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