Combined intravoxel incoherent motion diffusion-weighted MR imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fractures
Abstract Purpose Our purpose was to combine intravoxel incoherent motion diffusion-weighted MR imaging (IVIM-DWI) and magnetic resonance spectroscopy (MRS) to differentiate osteoporotic fractures from osteolytic metastatic vertebral compression fractures (VCFs). Methods A total of 70 patients with V...
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-019-1350-3 |
| _version_ | 1798038494566678528 |
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| author | Hui Tan Hui Xu Feifei Luo Zhaoguo Zhang Zhen Yang Nan Yu Yong Yu Shaoyu Wang Qiuju Fan Yue Li |
| author_facet | Hui Tan Hui Xu Feifei Luo Zhaoguo Zhang Zhen Yang Nan Yu Yong Yu Shaoyu Wang Qiuju Fan Yue Li |
| author_sort | Hui Tan |
| collection | DOAJ |
| description | Abstract Purpose Our purpose was to combine intravoxel incoherent motion diffusion-weighted MR imaging (IVIM-DWI) and magnetic resonance spectroscopy (MRS) to differentiate osteoporotic fractures from osteolytic metastatic vertebral compression fractures (VCFs). Methods A total of 70 patients with VCFs were included and divided into two groups, according to their causes of fractures based on pathological findings or clinical follow-up. All patients underwent conventional sagittal T1WI, T2WI, STIR, IVIM-DWI, and single-voxel MRS. The diffusion coefficient (D), pseudo diffusion (D*), and perfusion fraction (f) parameters from IVIM-DWI and the lipid water ratio (LWR) and fat fraction (FF) parameters from MRS were obtained and compared among groups. Furthermore, the diagnostic performance of MRS, IVIM-DWI, and IVIM-DWI combined with MRS for differentiation between osteoporotic and osteolytic metastatic VCFs was assessed by using receiver operating characteristic (ROC) curve analysis. Results Compared with the osteoporotic group, the metastatic group had significantly lower values for f, D, and FF, but higher D* (all P < 0.05). The area under the receiver operating characteristic (ROC) curve of MRS, IVIM-DWI, and IVIM-DWI combined with MRS were 0.73, 0.88, and 0.94, respectively. Among these, the IVIM-DWI combined with MRS showed the highest sensitivity, specificity, and accuracy, which are 90.63% (29/32), 97.37 % (37/38), and 94.29% (66/70), respectively. Conclusions IVIM-DWI combined with MRS can be more accurate and efficient for differentiation between osteoporotic and osteolytic metastatic VCFs than single MRS or IVIM-DWI. |
| first_indexed | 2024-04-11T21:40:59Z |
| format | Article |
| id | doaj.art-289943934785451bbd7d146320fe284e |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T21:40:59Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-289943934785451bbd7d146320fe284e2022-12-22T04:01:35ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2019-09-011411910.1186/s13018-019-1350-3Combined intravoxel incoherent motion diffusion-weighted MR imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fracturesHui Tan0Hui Xu1Feifei Luo2Zhaoguo Zhang3Zhen Yang4Nan Yu5Yong Yu6Shaoyu Wang7Qiuju Fan8Yue Li9Institute of Medical Technology, Shaanxi University of Chinese MedicineDepartment of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong UniversityInstitute of Medical Technology, Shaanxi University of Chinese MedicineInstitute of Medical Technology, Shaanxi University of Chinese MedicineInstitute of Medical Technology, Shaanxi University of Chinese MedicineInstitute of Medical Technology, Shaanxi University of Chinese MedicineSiemens HealthineersInstitute of Medical Technology, Shaanxi University of Chinese MedicineInstitute of Medical Technology, Shaanxi University of Chinese MedicineAbstract Purpose Our purpose was to combine intravoxel incoherent motion diffusion-weighted MR imaging (IVIM-DWI) and magnetic resonance spectroscopy (MRS) to differentiate osteoporotic fractures from osteolytic metastatic vertebral compression fractures (VCFs). Methods A total of 70 patients with VCFs were included and divided into two groups, according to their causes of fractures based on pathological findings or clinical follow-up. All patients underwent conventional sagittal T1WI, T2WI, STIR, IVIM-DWI, and single-voxel MRS. The diffusion coefficient (D), pseudo diffusion (D*), and perfusion fraction (f) parameters from IVIM-DWI and the lipid water ratio (LWR) and fat fraction (FF) parameters from MRS were obtained and compared among groups. Furthermore, the diagnostic performance of MRS, IVIM-DWI, and IVIM-DWI combined with MRS for differentiation between osteoporotic and osteolytic metastatic VCFs was assessed by using receiver operating characteristic (ROC) curve analysis. Results Compared with the osteoporotic group, the metastatic group had significantly lower values for f, D, and FF, but higher D* (all P < 0.05). The area under the receiver operating characteristic (ROC) curve of MRS, IVIM-DWI, and IVIM-DWI combined with MRS were 0.73, 0.88, and 0.94, respectively. Among these, the IVIM-DWI combined with MRS showed the highest sensitivity, specificity, and accuracy, which are 90.63% (29/32), 97.37 % (37/38), and 94.29% (66/70), respectively. Conclusions IVIM-DWI combined with MRS can be more accurate and efficient for differentiation between osteoporotic and osteolytic metastatic VCFs than single MRS or IVIM-DWI.http://link.springer.com/article/10.1186/s13018-019-1350-3VertebraFracturesOsteoporoticIVIM-DWIMRS |
| spellingShingle | Hui Tan Hui Xu Feifei Luo Zhaoguo Zhang Zhen Yang Nan Yu Yong Yu Shaoyu Wang Qiuju Fan Yue Li Combined intravoxel incoherent motion diffusion-weighted MR imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fractures Journal of Orthopaedic Surgery and Research Vertebra Fractures Osteoporotic IVIM-DWI MRS |
| title | Combined intravoxel incoherent motion diffusion-weighted MR imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fractures |
| title_full | Combined intravoxel incoherent motion diffusion-weighted MR imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fractures |
| title_fullStr | Combined intravoxel incoherent motion diffusion-weighted MR imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fractures |
| title_full_unstemmed | Combined intravoxel incoherent motion diffusion-weighted MR imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fractures |
| title_short | Combined intravoxel incoherent motion diffusion-weighted MR imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fractures |
| title_sort | combined intravoxel incoherent motion diffusion weighted mr imaging and magnetic resonance spectroscopy in differentiation between osteoporotic and metastatic vertebral compression fractures |
| topic | Vertebra Fractures Osteoporotic IVIM-DWI MRS |
| url | http://link.springer.com/article/10.1186/s13018-019-1350-3 |
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