Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease
Background and Purpose The substantia innominata (SI) contains the nucleus basalis of Meynert, which is the major source of cholinergic input to the cerebral cortex. We hypothesized that degeneration of the SI and its relationship to general cognitive performance differs in amyloidopathy and synucle...
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2011-10-01
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| Series: | Journal of Movement Disorders |
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| Online Access: | http://e-jmd.org/upload/jmd-4-2-68-4.pdf |
| _version_ | 1827882976541671424 |
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| author | Hee Jin Kim Ji Eun Lee Soo Jeong Shin Young Ho Sohn Phil Hyu Lee |
| author_facet | Hee Jin Kim Ji Eun Lee Soo Jeong Shin Young Ho Sohn Phil Hyu Lee |
| author_sort | Hee Jin Kim |
| collection | DOAJ |
| description | Background and Purpose The substantia innominata (SI) contains the nucleus basalis of Meynert, which is the major source of cholinergic input to the cerebral cortex. We hypothesized that degeneration of the SI and its relationship to general cognitive performance differs in amyloidopathy and synucleinopathy. Methods We used magnetic resonance imaging (MRI)-based volumetric analysis to evaluate the SI volume in patients with amnestic mild cognitive impairment (aMCI), Alzheimer’s disease (AD), Parkinson’s disease-mild cognitive impairment (PD-MCI), PD with dementia (PDD), dementia with Lewy bodies (DLB), and healthy elderly controls. The correlation between SI volume and general cognitive performance, measured using the Korean version of the Mini-Mental State Examination (K-MMSE), was examined. Results Compared to control subjects, the mean normalized SI volume was significantly decreased in all of the other groups. The normalized SI volume did not differ between the subjects with PDD and DLB, whereas it was significantly smaller in subjects with PDD (p = 0.029) and DLB (p = 0.011) compared with AD. In subjects with PD-related cognitive impairment (PD-MCI, PDD, or DLB), there was a significant positive correlation between the SI volume and K-MMSE score (r = 0.366, p < 0.001), whereas no correlation was seen in subjects with AD-related cognitive impairment (aMCI or AD). Conclusions Our data suggest that the SI loss is greater in synucleinopathy-related dementia (PDD or DLB) than in AD and that the contribution of the SI to cognitive performance is greater in synucleinopathy than in amyloidopathy. |
| first_indexed | 2024-03-12T19:04:59Z |
| format | Article |
| id | doaj.art-289b254087424d7fb1cf40db30f3cbe8 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T19:04:59Z |
| publishDate | 2011-10-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-289b254087424d7fb1cf40db30f3cbe82023-08-02T06:17:08ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392011-10-0142687210.14802/jmd.1101428Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s DiseaseHee Jin KimJi Eun LeeSoo Jeong ShinYoung Ho SohnPhil Hyu LeeBackground and Purpose The substantia innominata (SI) contains the nucleus basalis of Meynert, which is the major source of cholinergic input to the cerebral cortex. We hypothesized that degeneration of the SI and its relationship to general cognitive performance differs in amyloidopathy and synucleinopathy. Methods We used magnetic resonance imaging (MRI)-based volumetric analysis to evaluate the SI volume in patients with amnestic mild cognitive impairment (aMCI), Alzheimer’s disease (AD), Parkinson’s disease-mild cognitive impairment (PD-MCI), PD with dementia (PDD), dementia with Lewy bodies (DLB), and healthy elderly controls. The correlation between SI volume and general cognitive performance, measured using the Korean version of the Mini-Mental State Examination (K-MMSE), was examined. Results Compared to control subjects, the mean normalized SI volume was significantly decreased in all of the other groups. The normalized SI volume did not differ between the subjects with PDD and DLB, whereas it was significantly smaller in subjects with PDD (p = 0.029) and DLB (p = 0.011) compared with AD. In subjects with PD-related cognitive impairment (PD-MCI, PDD, or DLB), there was a significant positive correlation between the SI volume and K-MMSE score (r = 0.366, p < 0.001), whereas no correlation was seen in subjects with AD-related cognitive impairment (aMCI or AD). Conclusions Our data suggest that the SI loss is greater in synucleinopathy-related dementia (PDD or DLB) than in AD and that the contribution of the SI to cognitive performance is greater in synucleinopathy than in amyloidopathy.http://e-jmd.org/upload/jmd-4-2-68-4.pdfThe substantia innominataAlzheimer’s diseaseParkinson’s disease-related cognitive dysfunction |
| spellingShingle | Hee Jin Kim Ji Eun Lee Soo Jeong Shin Young Ho Sohn Phil Hyu Lee Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease Journal of Movement Disorders The substantia innominata Alzheimer’s disease Parkinson’s disease-related cognitive dysfunction |
| title | Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease |
| title_full | Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease |
| title_fullStr | Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease |
| title_full_unstemmed | Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease |
| title_short | Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease |
| title_sort | analysis of the substantia innominata volume in patients with parkinson s disease with dementia dementia with lewy bodies and alzheimer s disease |
| topic | The substantia innominata Alzheimer’s disease Parkinson’s disease-related cognitive dysfunction |
| url | http://e-jmd.org/upload/jmd-4-2-68-4.pdf |
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