<i>Toxoplasma gondii</i> Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm Animals
Toxoplasmosis is caused by an intracellular protozoan, <i>Toxoplasma gondii</i>, and is a parasitic disease that occurs in all warm-blooded animals, including humans. Toxoplasmosis is one of the most common parasitic diseases of animals and results in reproductive losses. Toxoplasmosis i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/10/8/1245 |
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| author | Bartłomiej Ferra Lucyna Holec-Gąsior Weronika Grąźlewska |
| author_facet | Bartłomiej Ferra Lucyna Holec-Gąsior Weronika Grąźlewska |
| author_sort | Bartłomiej Ferra |
| collection | DOAJ |
| description | Toxoplasmosis is caused by an intracellular protozoan, <i>Toxoplasma gondii</i>, and is a parasitic disease that occurs in all warm-blooded animals, including humans. Toxoplasmosis is one of the most common parasitic diseases of animals and results in reproductive losses. Toxoplasmosis in humans is usually caused by eating raw or undercooked meat or consuming dairy products containing the parasite. Diagnosis of toxoplasmosis is currently based on serological assays using native antigens to detect specific anti-<i>T. gondii</i> antibodies. Due to the high price, the available commercial agglutination assays are not suited to test a large number of animal serum samples. The recent development of proteomics elucidated the antigenic structure of <i>T. gondii</i> and enabled the development of various recombinant antigens that can be used in new, cheaper, and more effective diagnostic tools. Continuous development of scientific disciplines, such as molecular biology and genetic engineering, allows for the production of new recombinant antigens and provides the basis for new diagnostic tests for the detection of anti-<i>T. gondii</i> antibodies in animal serum samples. |
| first_indexed | 2024-03-10T18:17:40Z |
| format | Article |
| id | doaj.art-289b658952d9435e96a254d4f06b7500 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T18:17:40Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-289b658952d9435e96a254d4f06b75002023-11-20T07:32:07ZengMDPI AGAnimals2076-26152020-07-01108124510.3390/ani10081245<i>Toxoplasma gondii</i> Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm AnimalsBartłomiej Ferra0Lucyna Holec-Gąsior1Weronika Grąźlewska2Department of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12 Str., 80-233 Gdansk, PolandDepartment of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12 Str., 80-233 Gdansk, PolandDepartment of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12 Str., 80-233 Gdansk, PolandToxoplasmosis is caused by an intracellular protozoan, <i>Toxoplasma gondii</i>, and is a parasitic disease that occurs in all warm-blooded animals, including humans. Toxoplasmosis is one of the most common parasitic diseases of animals and results in reproductive losses. Toxoplasmosis in humans is usually caused by eating raw or undercooked meat or consuming dairy products containing the parasite. Diagnosis of toxoplasmosis is currently based on serological assays using native antigens to detect specific anti-<i>T. gondii</i> antibodies. Due to the high price, the available commercial agglutination assays are not suited to test a large number of animal serum samples. The recent development of proteomics elucidated the antigenic structure of <i>T. gondii</i> and enabled the development of various recombinant antigens that can be used in new, cheaper, and more effective diagnostic tools. Continuous development of scientific disciplines, such as molecular biology and genetic engineering, allows for the production of new recombinant antigens and provides the basis for new diagnostic tests for the detection of anti-<i>T. gondii</i> antibodies in animal serum samples.https://www.mdpi.com/2076-2615/10/8/1245<i>Toxoplasma gondii</i>toxoplasmosisrecombinant antigensserodiagnosisanimals |
| spellingShingle | Bartłomiej Ferra Lucyna Holec-Gąsior Weronika Grąźlewska <i>Toxoplasma gondii</i> Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm Animals Animals <i>Toxoplasma gondii</i> toxoplasmosis recombinant antigens serodiagnosis animals |
| title | <i>Toxoplasma gondii</i> Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm Animals |
| title_full | <i>Toxoplasma gondii</i> Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm Animals |
| title_fullStr | <i>Toxoplasma gondii</i> Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm Animals |
| title_full_unstemmed | <i>Toxoplasma gondii</i> Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm Animals |
| title_short | <i>Toxoplasma gondii</i> Recombinant Antigens in the Serodiagnosis of Toxoplasmosis in Domestic and Farm Animals |
| title_sort | i toxoplasma gondii i recombinant antigens in the serodiagnosis of toxoplasmosis in domestic and farm animals |
| topic | <i>Toxoplasma gondii</i> toxoplasmosis recombinant antigens serodiagnosis animals |
| url | https://www.mdpi.com/2076-2615/10/8/1245 |
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