Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population
Profiles of circulating amino acids have been associated with cardiometabolic diseases. We investigated the associations between dietary protein intake, physical activity and adiposity and serum amino acid profiles in an Asian population. We used data from 3009 male and female participants from the...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2603 |
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| author | Samuel H. Gunther Chin Meng Khoo Xueling Sim E Shyong Tai Rob M. van Dam |
| author_facet | Samuel H. Gunther Chin Meng Khoo Xueling Sim E Shyong Tai Rob M. van Dam |
| author_sort | Samuel H. Gunther |
| collection | DOAJ |
| description | Profiles of circulating amino acids have been associated with cardiometabolic diseases. We investigated the associations between dietary protein intake, physical activity and adiposity and serum amino acid profiles in an Asian population. We used data from 3009 male and female participants from the Singapore Prospective Study Program cohort. Dietary and physical activity data were obtained from validated questionnaires; anthropometric measurements were collected during a health examination; and fasting concentrations of 16 amino acids were measured using targeted LC-MS. The association between lifestyle factors and amino acid levels was modeled using multiple linear regression with adjustment for other sociodemographic and lifestyle factors and correction for multiple testing. We observed significant associations between seafood intake (<i>β</i>-coefficient 0.132, 95% CI 0.006, 0.257 for a 100% increment), physical activity (<i>β</i>-coefficient −0.096, 95% CI −0.183, −0.008 in the highest versus lowest quartile) and adiposity (BMI <i>β</i>-coefficient 0.062, 95% CI 0.054, 0.070 per kg/m<sup>2</sup>; waist circumference <i>β</i>-coefficient 0.034, 95% CI 0.031, 0.037 per cm) and branched-chain amino acid levels (expressed per-SD). We also observed significant interactions with sex for the association between meat and seafood and total intakes and BCAA levels (<i>P</i> for interaction 0.007), which were stronger in females than in males. Our findings suggest novel associations between modifiable lifestyle factors and amino acid levels in Asian populations. |
| first_indexed | 2024-03-10T16:46:38Z |
| format | Article |
| id | doaj.art-289b6e89b24e48e3a1df9608901a1447 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:46:38Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-289b6e89b24e48e3a1df9608901a14472023-11-20T11:31:18ZengMDPI AGNutrients2072-66432020-08-01129260310.3390/nu12092603Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian PopulationSamuel H. Gunther0Chin Meng Khoo1Xueling Sim2E Shyong Tai3Rob M. van Dam4Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University Health System, Singapore 119228, SingaporeSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, SingaporeSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, SingaporeSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, SingaporeProfiles of circulating amino acids have been associated with cardiometabolic diseases. We investigated the associations between dietary protein intake, physical activity and adiposity and serum amino acid profiles in an Asian population. We used data from 3009 male and female participants from the Singapore Prospective Study Program cohort. Dietary and physical activity data were obtained from validated questionnaires; anthropometric measurements were collected during a health examination; and fasting concentrations of 16 amino acids were measured using targeted LC-MS. The association between lifestyle factors and amino acid levels was modeled using multiple linear regression with adjustment for other sociodemographic and lifestyle factors and correction for multiple testing. We observed significant associations between seafood intake (<i>β</i>-coefficient 0.132, 95% CI 0.006, 0.257 for a 100% increment), physical activity (<i>β</i>-coefficient −0.096, 95% CI −0.183, −0.008 in the highest versus lowest quartile) and adiposity (BMI <i>β</i>-coefficient 0.062, 95% CI 0.054, 0.070 per kg/m<sup>2</sup>; waist circumference <i>β</i>-coefficient 0.034, 95% CI 0.031, 0.037 per cm) and branched-chain amino acid levels (expressed per-SD). We also observed significant interactions with sex for the association between meat and seafood and total intakes and BCAA levels (<i>P</i> for interaction 0.007), which were stronger in females than in males. Our findings suggest novel associations between modifiable lifestyle factors and amino acid levels in Asian populations.https://www.mdpi.com/2072-6643/12/9/2603branched-chain amino acidsdietary protein source and intakemetabolomics |
| spellingShingle | Samuel H. Gunther Chin Meng Khoo Xueling Sim E Shyong Tai Rob M. van Dam Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population Nutrients branched-chain amino acids dietary protein source and intake metabolomics |
| title | Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population |
| title_full | Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population |
| title_fullStr | Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population |
| title_full_unstemmed | Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population |
| title_short | Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population |
| title_sort | diet physical activity and adiposity as determinants of circulating amino acid levels in a multiethnic asian population |
| topic | branched-chain amino acids dietary protein source and intake metabolomics |
| url | https://www.mdpi.com/2072-6643/12/9/2603 |
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