Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma

Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma

Abstract Rhabdomyosarcoma (RMS) is an aggressive pediatric tumor with a poor prognosis for metastasis and recurrent disease. Large-scale sequencing endeavors demonstrate that Rhabdomyosarcomas have a dearth of precisely targetable driver mutations. However, IGF-2 signaling is known to be grossly alt...

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Bibliographic Details
Main Authors: Safiya Khurshid, Matias Montes, Daniel F. Comiskey, Brianne Shane, Eleftheria Matsa, Francesca Jung, Chelsea Brown, Hemant Kumar Bid, Ruoning Wang, Peter J. Houghton, Ryan Roberts, Frank Rigo, Dawn Chandler
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-021-00245-5

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