Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats
Objective: To evaluate the neuroprotective effect of ashwagandha extract against aluminum chloride-induced neurotoxicity in rats. Methods: Rats were divided into control, aluminum-intoxicated rats treated daily with aluminum trichloride (AlCl3) (100 mg/kg, orally) for 30 d and aluminum-intoxicated a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=1;spage=59;epage=66;aulast=Elhadidy |
| _version_ | 1818827801644498944 |
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| author | Mohamed E Elhadidy Hussein G Sawie Nagwa A Meguid Yasser A Khadrawy |
| author_facet | Mohamed E Elhadidy Hussein G Sawie Nagwa A Meguid Yasser A Khadrawy |
| author_sort | Mohamed E Elhadidy |
| collection | DOAJ |
| description | Objective: To evaluate the neuroprotective effect of ashwagandha extract against aluminum chloride-induced neurotoxicity in rats. Methods: Rats were divided into control, aluminum-intoxicated rats treated daily with aluminum trichloride (AlCl3) (100 mg/kg, orally) for 30 d and aluminum-intoxicated animals protected by receiving daily ashwagandha extract (200 mg/kg, orally) one hour before AlCl3 administration for 30 d. Levels of lipid peroxidation, nitric oxide, reduced glutathione and tumor necrosis factor-α were measured in the cortex, hippocampus and striatum. In addition, the activities of Na+, K+, ATPase and acetylcholinesterase were determined in the three studied brain regions. Results: Aluminum increased the levels of lipid peroxidation and nitric oxide in the cortex, hippocampus and striatum and decreased the reduced glutathione level in the hippocampus and striatum. In rats protected with ashwagandha extract, non significant changes were observed in lipid peroxidation, nitric oxide and reduced glutathione. In addition, ashwagandha extracts prevented the increased activity of acetylcholinesterase and Na+, K+, ATPase induced by AlCl3 in the cortex, hippocampus and striatum. The present findings also showed that the significant increase in tumor necrosis factor-α induced by AlCl3 in the cortex and hippocampus was prevented by ashwagandha extract. Conclusions: The present results suggest that ashwagandha extract possesses antioxidant and anti-inflammatory effects against aluminum neurotoxicity. In addition, ashwagandha extract could prevent the decline in cholinergic activity by maintaining normal acetylcholinesterase activity. The later effect could recommend the use of ashwagandha as a memory enhancer. |
| first_indexed | 2024-12-19T00:49:20Z |
| format | Article |
| id | doaj.art-289d51e969294267aed29968755bbd60 |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-12-19T00:49:20Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-289d51e969294267aed29968755bbd602022-12-21T20:44:08ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912018-01-0181596610.4103/2221-1691.221139Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in ratsMohamed E ElhadidyHussein G SawieNagwa A MeguidYasser A KhadrawyObjective: To evaluate the neuroprotective effect of ashwagandha extract against aluminum chloride-induced neurotoxicity in rats. Methods: Rats were divided into control, aluminum-intoxicated rats treated daily with aluminum trichloride (AlCl3) (100 mg/kg, orally) for 30 d and aluminum-intoxicated animals protected by receiving daily ashwagandha extract (200 mg/kg, orally) one hour before AlCl3 administration for 30 d. Levels of lipid peroxidation, nitric oxide, reduced glutathione and tumor necrosis factor-α were measured in the cortex, hippocampus and striatum. In addition, the activities of Na+, K+, ATPase and acetylcholinesterase were determined in the three studied brain regions. Results: Aluminum increased the levels of lipid peroxidation and nitric oxide in the cortex, hippocampus and striatum and decreased the reduced glutathione level in the hippocampus and striatum. In rats protected with ashwagandha extract, non significant changes were observed in lipid peroxidation, nitric oxide and reduced glutathione. In addition, ashwagandha extracts prevented the increased activity of acetylcholinesterase and Na+, K+, ATPase induced by AlCl3 in the cortex, hippocampus and striatum. The present findings also showed that the significant increase in tumor necrosis factor-α induced by AlCl3 in the cortex and hippocampus was prevented by ashwagandha extract. Conclusions: The present results suggest that ashwagandha extract possesses antioxidant and anti-inflammatory effects against aluminum neurotoxicity. In addition, ashwagandha extract could prevent the decline in cholinergic activity by maintaining normal acetylcholinesterase activity. The later effect could recommend the use of ashwagandha as a memory enhancer.http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=1;spage=59;epage=66;aulast=Elhadidyashwagandhaneurotoxicityoxidative stresstnf-αacetylcholinesterasena+/k+-atpase |
| spellingShingle | Mohamed E Elhadidy Hussein G Sawie Nagwa A Meguid Yasser A Khadrawy Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats Asian Pacific Journal of Tropical Biomedicine ashwagandha neurotoxicity oxidative stress tnf-α acetylcholinesterase na+/k+-atpase |
| title | Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
| title_full | Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
| title_fullStr | Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
| title_full_unstemmed | Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
| title_short | Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
| title_sort | protective effect of ashwagandha withania somnifera against neurotoxicity induced by aluminum chloride in rats |
| topic | ashwagandha neurotoxicity oxidative stress tnf-α acetylcholinesterase na+/k+-atpase |
| url | http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=1;spage=59;epage=66;aulast=Elhadidy |
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