Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and child
This report describes a case of Toxoplasma encephalitis during pregnancy of an HIV infected woman who was severely immunosuppressed (CD4: 17 cells/mm3), had a high viral load (RNA PCR:230,000 copies/ml), was treated with sulfadiazine, pyrimethamine and folinic acid for toxoplasmosis and was being tr...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400008&lng=en&tlng=en |
| _version_ | 1818244246411411456 |
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| author | Susie Andries Nogueira Ana Lúcia Guedes Elizabeth S. Machado Juliana A. Matos Tomás P. Costa Ely M. Cortes John S. Lambert |
| author_facet | Susie Andries Nogueira Ana Lúcia Guedes Elizabeth S. Machado Juliana A. Matos Tomás P. Costa Ely M. Cortes John S. Lambert |
| author_sort | Susie Andries Nogueira |
| collection | DOAJ |
| description | This report describes a case of Toxoplasma encephalitis during pregnancy of an HIV infected woman who was severely immunosuppressed (CD4: 17 cells/mm3), had a high viral load (RNA PCR:230,000 copies/ml), was treated with sulfadiazine, pyrimethamine and folinic acid for toxoplasmosis and was being treated with highly potent antiretroviral drugs (AZT, 3TC and nelfinavir) for HIV infection. The newborn was born through an elective C-section, received six weeks of AZT according to the 076 protocol and was clinically normal at birth. Subsequently he had two RNA PCR negatives for HIV, seroreverted and had no clinical or laboratory evidence of congenital toxoplasmosis. Despite the concerns of the use of these combined therapies on the foetus during pregnancy, their efficacy illustrates that keeping the mother alive and in good health is an important strategy to protect the unborn child from acquiring these two infections. |
| first_indexed | 2024-12-12T14:13:58Z |
| format | Article |
| id | doaj.art-289dbc1f20904ef581f3cd9d21b776a4 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-12T14:13:58Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-289dbc1f20904ef581f3cd9d21b776a42022-12-22T00:21:58ZengElsevierBrazilian Journal of Infectious Diseases1678-43916420120510.1590/S1413-86702002000400008S1413-86702002000400008Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and childSusie Andries Nogueira0Ana Lúcia GuedesElizabeth S. MachadoJuliana A. MatosTomás P. CostaEly M. CortesJohn S. LambertUniversidade Federal do Rio de JaneiroThis report describes a case of Toxoplasma encephalitis during pregnancy of an HIV infected woman who was severely immunosuppressed (CD4: 17 cells/mm3), had a high viral load (RNA PCR:230,000 copies/ml), was treated with sulfadiazine, pyrimethamine and folinic acid for toxoplasmosis and was being treated with highly potent antiretroviral drugs (AZT, 3TC and nelfinavir) for HIV infection. The newborn was born through an elective C-section, received six weeks of AZT according to the 076 protocol and was clinically normal at birth. Subsequently he had two RNA PCR negatives for HIV, seroreverted and had no clinical or laboratory evidence of congenital toxoplasmosis. Despite the concerns of the use of these combined therapies on the foetus during pregnancy, their efficacy illustrates that keeping the mother alive and in good health is an important strategy to protect the unborn child from acquiring these two infections.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400008&lng=en&tlng=enToxoplasma encephalitispregnancyHIV/AIDSprevention of vertical transmission |
| spellingShingle | Susie Andries Nogueira Ana Lúcia Guedes Elizabeth S. Machado Juliana A. Matos Tomás P. Costa Ely M. Cortes John S. Lambert Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and child Brazilian Journal of Infectious Diseases Toxoplasma encephalitis pregnancy HIV/AIDS prevention of vertical transmission |
| title | Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and child |
| title_full | Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and child |
| title_fullStr | Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and child |
| title_full_unstemmed | Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and child |
| title_short | Toxoplasmic encephalitis in an HIV infected pregnant woman: successful outcome for both mother and child |
| title_sort | toxoplasmic encephalitis in an hiv infected pregnant woman successful outcome for both mother and child |
| topic | Toxoplasma encephalitis pregnancy HIV/AIDS prevention of vertical transmission |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400008&lng=en&tlng=en |
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