Anti-nociceptive effect of atomoxetine on paclitaxel-induced neuropathic pain in mice and role of alpha-2 adrenergic receptor
Background: Neuropathic pain due to chemotherapy is one of the most important types of chronic pain that despite the increasing advances in medical sciences, its treatment is associated with many problems. In this study, the effects of atomoxetine on paclitaxel- induced neuropathic pain and the e...
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| Format: | Article |
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Kashan University of Medical Sciences and Health Services
2022-04-01
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| Series: | Fiyz̤ |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-4526-en.html |
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| author | Azam Mesdaghinia Hamidreza Banafshe Alireza Moravveji Ghazal Hajiagajani Narges Esmaeilian Alireza Abed |
| author_facet | Azam Mesdaghinia Hamidreza Banafshe Alireza Moravveji Ghazal Hajiagajani Narges Esmaeilian Alireza Abed |
| author_sort | Azam Mesdaghinia |
| collection | DOAJ |
| description | Background: Neuropathic pain due to chemotherapy is one of the most important types of
chronic pain that despite the increasing advances in medical sciences, its treatment is
associated with many problems. In this study, the effects of atomoxetine on paclitaxel-
induced neuropathic pain and the effect of alpha-2 adrenergic receptor antagonist
(yohimbine) on the analgesic effect of atomoxetine were investigated.
Materials and Methods: Male mice received paclitaxel (2 mg/kg i.p.) from the first to the
fifth day and atomoxetine (5, 10, and 15 mg/kg p.o.) was administered from the day 6 to 10.
Mice were divided into different groups (n=8) and each group received a unique dose of the
drug. On days 9, 10 and 11, Von Frey and acetone tests were performed. Also, the effect of
alpha-2 adrenergic receptor antagonist (yohimbine) on the analgesic effect of atomoxetine
was investigated. For this purpose, after pain induction, mice received atomoxetine (15
mg/kg p.o) with yohimbine (5 mg/kg i.p. 5) from day 6 to 10.
Results: Daily administration of atomoxetine (15 mg/kg p.o) effectively increased pain
threshold in the cold and mechanical allodynia tests (P<0.01). Administration a single dose
of atomoxetine on the 11th day did not alter behavioral tests.
Conclusion: According to these findings, it can be concluded that atomoxetine is able to
reduce the severity of paclitaxel-induced neuropathic pain. |
| first_indexed | 2024-04-13T06:43:36Z |
| format | Article |
| id | doaj.art-289dc0c34ff04203995a97dbbfbc4647 |
| institution | Directory Open Access Journal |
| issn | 1029-7855 2008-9821 |
| language | fas |
| last_indexed | 2024-04-13T06:43:36Z |
| publishDate | 2022-04-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-289dc0c34ff04203995a97dbbfbc46472022-12-22T02:57:40ZfasKashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212022-04-0126118Anti-nociceptive effect of atomoxetine on paclitaxel-induced neuropathic pain in mice and role of alpha-2 adrenergic receptorAzam Mesdaghinia 0Hamidreza Banafshe 1Alireza Moravveji 2Ghazal Hajiagajani3Narges Esmaeilian4 Alireza Abed 5Physiology Research Center, Kashan University of Medical Sciences, Kashan, I.R. IranPhysiology Research Center, Kashan University of Medical Sciences, Kashan, I.R. IranDepartment of Community Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran.Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. IranStudent Research Committee, Kashan University of Medical Sciences, Kashan, I.R. IranPhysiology Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran.Background: Neuropathic pain due to chemotherapy is one of the most important types of chronic pain that despite the increasing advances in medical sciences, its treatment is associated with many problems. In this study, the effects of atomoxetine on paclitaxel- induced neuropathic pain and the effect of alpha-2 adrenergic receptor antagonist (yohimbine) on the analgesic effect of atomoxetine were investigated. Materials and Methods: Male mice received paclitaxel (2 mg/kg i.p.) from the first to the fifth day and atomoxetine (5, 10, and 15 mg/kg p.o.) was administered from the day 6 to 10. Mice were divided into different groups (n=8) and each group received a unique dose of the drug. On days 9, 10 and 11, Von Frey and acetone tests were performed. Also, the effect of alpha-2 adrenergic receptor antagonist (yohimbine) on the analgesic effect of atomoxetine was investigated. For this purpose, after pain induction, mice received atomoxetine (15 mg/kg p.o) with yohimbine (5 mg/kg i.p. 5) from day 6 to 10. Results: Daily administration of atomoxetine (15 mg/kg p.o) effectively increased pain threshold in the cold and mechanical allodynia tests (P<0.01). Administration a single dose of atomoxetine on the 11th day did not alter behavioral tests. Conclusion: According to these findings, it can be concluded that atomoxetine is able to reduce the severity of paclitaxel-induced neuropathic pain.http://feyz.kaums.ac.ir/article-1-4526-en.htmlneuropathic painpaclitaxelatomoxetineallodyniamice |
| spellingShingle | Azam Mesdaghinia Hamidreza Banafshe Alireza Moravveji Ghazal Hajiagajani Narges Esmaeilian Alireza Abed Anti-nociceptive effect of atomoxetine on paclitaxel-induced neuropathic pain in mice and role of alpha-2 adrenergic receptor Fiyz̤ neuropathic pain paclitaxel atomoxetine allodynia mice |
| title | Anti-nociceptive effect of atomoxetine on paclitaxel-induced neuropathic pain in mice and role of alpha-2 adrenergic receptor |
| title_full | Anti-nociceptive effect of atomoxetine on paclitaxel-induced neuropathic pain in mice and role of alpha-2 adrenergic receptor |
| title_fullStr | Anti-nociceptive effect of atomoxetine on paclitaxel-induced neuropathic pain in mice and role of alpha-2 adrenergic receptor |
| title_full_unstemmed | Anti-nociceptive effect of atomoxetine on paclitaxel-induced neuropathic pain in mice and role of alpha-2 adrenergic receptor |
| title_short | Anti-nociceptive effect of atomoxetine on paclitaxel-induced neuropathic pain in mice and role of alpha-2 adrenergic receptor |
| title_sort | anti nociceptive effect of atomoxetine on paclitaxel induced neuropathic pain in mice and role of alpha 2 adrenergic receptor |
| topic | neuropathic pain paclitaxel atomoxetine allodynia mice |
| url | http://feyz.kaums.ac.ir/article-1-4526-en.html |
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