COVID-19: Immunopathogenesis
Coronavirus-19 disease (COVID-19) first described in Wuhan, China at the end of 2019. It spread rapidly all over the world and claimed the lives of over 300,000 people. There is no known effective vaccine and treatment yet. It is impossible to develop vaccines and specific treatment without understa...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2020-06-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
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| Online Access: | http://www.floradergisi.org/managete/fu_folder/2020-02/2020-25-02-121-131.pdf |
| _version_ | 1797906147916644352 |
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| author | Deniz MAVİ Ahmet Çağkan İNKAYA |
| author_facet | Deniz MAVİ Ahmet Çağkan İNKAYA |
| author_sort | Deniz MAVİ |
| collection | DOAJ |
| description | Coronavirus-19 disease (COVID-19) first described in Wuhan, China at the end of 2019. It spread rapidly all over the world and claimed the lives of over 300,000 people. There is no known effective vaccine and treatment yet. It is impossible to develop vaccines and specific treatment without understanding the pathogenesis of the disease. Experience from severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks may help to elucidate the pathogenesis of COVID-19. Nevertheless, many issues remained obscure regarding the pathogenesis of SARS-CoV-2. Exaggerated immune response leads to respiratory failure and even complications which may culminate in death. Cytokines storm, the complement system, endothelial damage, coagulation cascade, cellular and humoral immunity all play an important role in immune pathogenesis and inflammation. In this review, the relationship between the immune response/host characteristics of SARS-CoV-2 and the severity of the disease, antibody responses, and immune pathogenesis, possible causes of hypercoagulation will be discussed and it’s aimed to provide perspective on the development of effective vaccines and specific treatment. |
| first_indexed | 2024-04-10T10:16:27Z |
| format | Article |
| id | doaj.art-289f8155147140d68df7d9da1932bba2 |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T10:16:27Z |
| publishDate | 2020-06-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-289f8155147140d68df7d9da1932bba22023-02-15T16:21:51ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X2020-06-0125212113110.5578/flora.69606COVID-19: ImmunopathogenesisDeniz MAVİ0https://orcid.org/0000-0003-4723-1554Ahmet Çağkan İNKAYA1https://orcid.org/0000-0001-7943-8715Faculty of Medicine, University of Hacettepe, Ankara, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Hacettepe, Ankara, TurkeyCoronavirus-19 disease (COVID-19) first described in Wuhan, China at the end of 2019. It spread rapidly all over the world and claimed the lives of over 300,000 people. There is no known effective vaccine and treatment yet. It is impossible to develop vaccines and specific treatment without understanding the pathogenesis of the disease. Experience from severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks may help to elucidate the pathogenesis of COVID-19. Nevertheless, many issues remained obscure regarding the pathogenesis of SARS-CoV-2. Exaggerated immune response leads to respiratory failure and even complications which may culminate in death. Cytokines storm, the complement system, endothelial damage, coagulation cascade, cellular and humoral immunity all play an important role in immune pathogenesis and inflammation. In this review, the relationship between the immune response/host characteristics of SARS-CoV-2 and the severity of the disease, antibody responses, and immune pathogenesis, possible causes of hypercoagulation will be discussed and it’s aimed to provide perspective on the development of effective vaccines and specific treatment.http://www.floradergisi.org/managete/fu_folder/2020-02/2020-25-02-121-131.pdfsars-covsars-cov-2immunopathogenesiscytokine storm |
| spellingShingle | Deniz MAVİ Ahmet Çağkan İNKAYA COVID-19: Immunopathogenesis Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi sars-cov sars-cov-2 immunopathogenesis cytokine storm |
| title | COVID-19: Immunopathogenesis |
| title_full | COVID-19: Immunopathogenesis |
| title_fullStr | COVID-19: Immunopathogenesis |
| title_full_unstemmed | COVID-19: Immunopathogenesis |
| title_short | COVID-19: Immunopathogenesis |
| title_sort | covid 19 immunopathogenesis |
| topic | sars-cov sars-cov-2 immunopathogenesis cytokine storm |
| url | http://www.floradergisi.org/managete/fu_folder/2020-02/2020-25-02-121-131.pdf |
| work_keys_str_mv | AT denizmavi covid19immunopathogenesis AT ahmetcagkaninkaya covid19immunopathogenesis |