Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant
Two different types of ordered mesoporous nanoparticles, namely MCM-41 and MCM-48, with similar pore sizes but different pore connectivity, were loaded with aprepitant via a passive diffusion method. The percentage of the loaded active agent, along with the encapsulation efficiency, was evaluated us...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/4/1896 |
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| author | Theodora Christoforidou Dimitra Giasafaki Eleftherios G. Andriotis Nikolaos Bouropoulos Nikoleta F. Theodoroula Ioannis S. Vizirianakis Theodore Steriotis Georgia Charalambopoulou Dimitrios G. Fatouros |
| author_facet | Theodora Christoforidou Dimitra Giasafaki Eleftherios G. Andriotis Nikolaos Bouropoulos Nikoleta F. Theodoroula Ioannis S. Vizirianakis Theodore Steriotis Georgia Charalambopoulou Dimitrios G. Fatouros |
| author_sort | Theodora Christoforidou |
| collection | DOAJ |
| description | Two different types of ordered mesoporous nanoparticles, namely MCM-41 and MCM-48, with similar pore sizes but different pore connectivity, were loaded with aprepitant via a passive diffusion method. The percentage of the loaded active agent, along with the encapsulation efficiency, was evaluated using High-performance Liquid Chromatography (HPLC) analysis complemented by Thermogravimetric Analysis (TGA). The determination of the pore properties of the mesoporous particles before and after the drug loading revealed the presence of confined aprepitant in the pore structure of the particles, while Powder X-ray Diffractometry(pXRD), Differential Scanning Calorimetry (DSC), and FTIR experiments indicated that the drug is in an amorphous state. The release profiles of the drug from the two different mesoporous materials were studied in various release media and revealed an aprepitant release up to 45% when sink conditions are applied. The cytocompatibility of the silica nanoparticles was assessed in Caco-2 cell monolayers, in the presence and absence of the active agent, suggesting that they can be used as carriers of aprepitant without presenting any toxicity in vitro. |
| first_indexed | 2024-03-09T00:52:14Z |
| format | Article |
| id | doaj.art-289fd65598ce4ce8ab3d59be4afa716a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T00:52:14Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-289fd65598ce4ce8ab3d59be4afa716a2023-12-11T17:04:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224189610.3390/ijms22041896Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of AprepitantTheodora Christoforidou0Dimitra Giasafaki1Eleftherios G. Andriotis2Nikolaos Bouropoulos3Nikoleta F. Theodoroula4Ioannis S. Vizirianakis5Theodore Steriotis6Georgia Charalambopoulou7Dimitrios G. Fatouros8Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceNational Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceLaboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceFoundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature Chemical Processes, 26504 Patras, GreeceLaboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceNational Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceNational Centre for Scientific Research “Demokritos”, 15341 Athens, GreeceLaboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceTwo different types of ordered mesoporous nanoparticles, namely MCM-41 and MCM-48, with similar pore sizes but different pore connectivity, were loaded with aprepitant via a passive diffusion method. The percentage of the loaded active agent, along with the encapsulation efficiency, was evaluated using High-performance Liquid Chromatography (HPLC) analysis complemented by Thermogravimetric Analysis (TGA). The determination of the pore properties of the mesoporous particles before and after the drug loading revealed the presence of confined aprepitant in the pore structure of the particles, while Powder X-ray Diffractometry(pXRD), Differential Scanning Calorimetry (DSC), and FTIR experiments indicated that the drug is in an amorphous state. The release profiles of the drug from the two different mesoporous materials were studied in various release media and revealed an aprepitant release up to 45% when sink conditions are applied. The cytocompatibility of the silica nanoparticles was assessed in Caco-2 cell monolayers, in the presence and absence of the active agent, suggesting that they can be used as carriers of aprepitant without presenting any toxicity in vitro.https://www.mdpi.com/1422-0067/22/4/1896mesoporous materialspoorly soluble drugsaprepitantoral delivery |
| spellingShingle | Theodora Christoforidou Dimitra Giasafaki Eleftherios G. Andriotis Nikolaos Bouropoulos Nikoleta F. Theodoroula Ioannis S. Vizirianakis Theodore Steriotis Georgia Charalambopoulou Dimitrios G. Fatouros Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant International Journal of Molecular Sciences mesoporous materials poorly soluble drugs aprepitant oral delivery |
| title | Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant |
| title_full | Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant |
| title_fullStr | Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant |
| title_full_unstemmed | Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant |
| title_short | Oral Drug Delivery Systems Based on Ordered Mesoporous Silica Nanoparticles for Modulating the Release of Aprepitant |
| title_sort | oral drug delivery systems based on ordered mesoporous silica nanoparticles for modulating the release of aprepitant |
| topic | mesoporous materials poorly soluble drugs aprepitant oral delivery |
| url | https://www.mdpi.com/1422-0067/22/4/1896 |
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