Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles
Abstract Silicon dioxide nanoparticles (SiO2 NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery. However, the toxicity of these NPs on human health and the ecosystem have not been extensively studied and little inform...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi-IET
2021-04-01
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| Series: | IET Nanobiotechnology |
| Online Access: | https://doi.org/10.1049/nbt2.12041 |
| _version_ | 1797428853571846144 |
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| author | Bashir Jarrar Amin Al‐Doaiss Ali Shati Mohammed Al‐Kahtani Qais Jarrar |
| author_facet | Bashir Jarrar Amin Al‐Doaiss Ali Shati Mohammed Al‐Kahtani Qais Jarrar |
| author_sort | Bashir Jarrar |
| collection | DOAJ |
| description | Abstract Silicon dioxide nanoparticles (SiO2 NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery. However, the toxicity of these NPs on human health and the ecosystem have not been extensively studied and little information is available about their behavioural toxicities. The current study aimed to find out the behavioural alterations that might be induced by chronic exposure to 10 nm SiO2 NPs. BALB/C mice were subjected to 36 injections of SiO2 NPs (2 mg/kg Bw) and subjected to 11 neurobehavioural tests: elevated plus‐maze test, elevated zero‐maze test, multiradial maze test, open field test, hole‐board test, light‐dark box test, forced swimming test, tail‐suspension test, Morris water‐maze test, Y‐maze test and multiple T‐maze test. Treated mice demonstrated anxiety‐like effect, depression tendency, behavioural despair stress, exploration and locomotors activity reduction with error induction in both reference and working memories. The findings may suggest that silica NPs are anxiogenic and could aggravate depression affecting memory, learning, overall activity and exploratory behaviour. Moreover, the findings may indicate that these nanomaterials (NMs) may induce potential oxidative stress in the body leading to neurobehavioural alterations with possible changes in the vital organ including the central nervous system. |
| first_indexed | 2024-03-09T09:04:50Z |
| format | Article |
| id | doaj.art-28a07f781a484f16a8a993989f2c9dd7 |
| institution | Directory Open Access Journal |
| issn | 1751-8741 1751-875X |
| language | English |
| last_indexed | 2024-03-09T09:04:50Z |
| publishDate | 2021-04-01 |
| publisher | Hindawi-IET |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj.art-28a07f781a484f16a8a993989f2c9dd72023-12-02T10:39:49ZengHindawi-IETIET Nanobiotechnology1751-87411751-875X2021-04-0115222123510.1049/nbt2.12041Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticlesBashir Jarrar0Amin Al‐Doaiss1Ali Shati2Mohammed Al‐Kahtani3Qais Jarrar4Nanobiology Unit Department of Biological Sciences College of Science Jerash University JordanDepartment of Biology College of Science King Khalid University Saudi ArabiaDepartment of Biology College of Science King Khalid University Saudi ArabiaDepartment of Biology College of Science King Khalid University Saudi ArabiaDepartment of Applied Pharmaceutical Sciences and Pharmacy Practice Faculty of Pharmacy Isra University JordanAbstract Silicon dioxide nanoparticles (SiO2 NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery. However, the toxicity of these NPs on human health and the ecosystem have not been extensively studied and little information is available about their behavioural toxicities. The current study aimed to find out the behavioural alterations that might be induced by chronic exposure to 10 nm SiO2 NPs. BALB/C mice were subjected to 36 injections of SiO2 NPs (2 mg/kg Bw) and subjected to 11 neurobehavioural tests: elevated plus‐maze test, elevated zero‐maze test, multiradial maze test, open field test, hole‐board test, light‐dark box test, forced swimming test, tail‐suspension test, Morris water‐maze test, Y‐maze test and multiple T‐maze test. Treated mice demonstrated anxiety‐like effect, depression tendency, behavioural despair stress, exploration and locomotors activity reduction with error induction in both reference and working memories. The findings may suggest that silica NPs are anxiogenic and could aggravate depression affecting memory, learning, overall activity and exploratory behaviour. Moreover, the findings may indicate that these nanomaterials (NMs) may induce potential oxidative stress in the body leading to neurobehavioural alterations with possible changes in the vital organ including the central nervous system.https://doi.org/10.1049/nbt2.12041 |
| spellingShingle | Bashir Jarrar Amin Al‐Doaiss Ali Shati Mohammed Al‐Kahtani Qais Jarrar Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles IET Nanobiotechnology |
| title | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
| title_full | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
| title_fullStr | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
| title_full_unstemmed | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
| title_short | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
| title_sort | behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
| url | https://doi.org/10.1049/nbt2.12041 |
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