Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma
Non-Hodgkin lymphoma (NHL) is a common type of hematological malignant tumor, composed of multiple subtypes that originate from B lymphocytes, T lymphocytes, and natural killer cells. A diagnosis of NHL depends on the results of a pathology examination, which requires an invasive tissue biopsy. Howe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.658234/full |
| _version_ | 1818615053554810880 |
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| author | Liwei Lv Yuanbo Liu |
| author_facet | Liwei Lv Yuanbo Liu |
| author_sort | Liwei Lv |
| collection | DOAJ |
| description | Non-Hodgkin lymphoma (NHL) is a common type of hematological malignant tumor, composed of multiple subtypes that originate from B lymphocytes, T lymphocytes, and natural killer cells. A diagnosis of NHL depends on the results of a pathology examination, which requires an invasive tissue biopsy. However, due to their invasive nature, tissue biopsies have many limitations in clinical applications, especially in terms of evaluating the therapeutic response and monitoring tumor progression. To overcome these limitations of traditional tissue biopsies, a technique known as “liquid biopsies” (LBs) was proposed. LBs refer to noninvasive examinations that can provide biological tumor data for analysis. Many studies have shown that LBs can be broadly applied to the diagnosis, treatment, prognosis, and monitoring of NHL. This article will briefly review various LB methods that aim to improve NHL management, including the evaluation of cell-free DNA/circulating tumor DNA, microRNA, and tumor-derived exosomes extracted from peripheral blood in NHL. |
| first_indexed | 2024-12-16T16:27:47Z |
| format | Article |
| id | doaj.art-28a2f5f55862482888a387f6972ff44e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T16:27:47Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-28a2f5f55862482888a387f6972ff44e2022-12-21T22:24:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.658234658234Clinical Application of Liquid Biopsy in Non-Hodgkin LymphomaLiwei LvYuanbo LiuNon-Hodgkin lymphoma (NHL) is a common type of hematological malignant tumor, composed of multiple subtypes that originate from B lymphocytes, T lymphocytes, and natural killer cells. A diagnosis of NHL depends on the results of a pathology examination, which requires an invasive tissue biopsy. However, due to their invasive nature, tissue biopsies have many limitations in clinical applications, especially in terms of evaluating the therapeutic response and monitoring tumor progression. To overcome these limitations of traditional tissue biopsies, a technique known as “liquid biopsies” (LBs) was proposed. LBs refer to noninvasive examinations that can provide biological tumor data for analysis. Many studies have shown that LBs can be broadly applied to the diagnosis, treatment, prognosis, and monitoring of NHL. This article will briefly review various LB methods that aim to improve NHL management, including the evaluation of cell-free DNA/circulating tumor DNA, microRNA, and tumor-derived exosomes extracted from peripheral blood in NHL.https://www.frontiersin.org/articles/10.3389/fonc.2021.658234/fullnon-Hodgkin lymphomadiffuse large B-cell lymphomaprimary central nervous system lymphomaliquid biopsiescell-free DNAcirculating tumor DNA |
| spellingShingle | Liwei Lv Yuanbo Liu Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma Frontiers in Oncology non-Hodgkin lymphoma diffuse large B-cell lymphoma primary central nervous system lymphoma liquid biopsies cell-free DNA circulating tumor DNA |
| title | Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma |
| title_full | Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma |
| title_fullStr | Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma |
| title_full_unstemmed | Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma |
| title_short | Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma |
| title_sort | clinical application of liquid biopsy in non hodgkin lymphoma |
| topic | non-Hodgkin lymphoma diffuse large B-cell lymphoma primary central nervous system lymphoma liquid biopsies cell-free DNA circulating tumor DNA |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.658234/full |
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