Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study
Objectives: The thyroid gland produces hormones that have significant influence on carbohydrate metabolism; its disorders may affect carbohydrate metabolism in type 2 diabetic patients (T2DM) more than the non-diabetic (NDM) patients as reported in various studies. We determined the spectrum of thyr...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121221097625 |
| _version_ | 1818005665332854784 |
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| author | Ahmed Kayode Jimoh Muritala Segun Ghazali Olajumoke Ajele Ogundeji Babajide Adewoyin Adeleke Oladimeji Gbadebo Ajani Emmanuel Olusegun Gabriel-Alayode Gbenga Omotade Popoola Olufemi Sola Adediran |
| author_facet | Ahmed Kayode Jimoh Muritala Segun Ghazali Olajumoke Ajele Ogundeji Babajide Adewoyin Adeleke Oladimeji Gbadebo Ajani Emmanuel Olusegun Gabriel-Alayode Gbenga Omotade Popoola Olufemi Sola Adediran |
| author_sort | Ahmed Kayode Jimoh |
| collection | DOAJ |
| description | Objectives: The thyroid gland produces hormones that have significant influence on carbohydrate metabolism; its disorders may affect carbohydrate metabolism in type 2 diabetic patients (T2DM) more than the non-diabetic (NDM) patients as reported in various studies. We determined the spectrum of thyroid function tests (TFTs) profile among T2DM in our rural health facility. Methods: T2DM patients and NDM patients were recruited for the study. The age, educational level, occupation, marital status, and duration of diabetes were extracted from interviewer’s administered questionnaire. The weight, height, body mass indices (BMIs), and the waist and hip circumferences were measured. Waist-hip ratios (WHR) were calculated for all participants. Venous blood was collected and assayed for free triiodothyronine (fT3), free thyroxine (fT4), and thyroid stimulating hormone (TSH) using a Chemiluminescence Immunoassay (CLIA) 2nd Generation Autoanalyzer. The mean, standard deviation, frequencies, and percentages were calculated for the variables. The student’s t-test and chi-square test were also determined as appropriate. Results: Seventy-eight patients made up of 56 T2DM and 22 NDM were evaluated in this study. Fifty-one were males while 27 were females; 67.9% and 59.1% of the female participants were T2DM and NDM, respectively. The WHR was significantly higher in T2DM than NDM (0.92 ± 0.05 versus 0.88 ± 0.06). The TSH was higher in T2DM than the NDM. Forty-four (78.6%) of the T2DM had euthyroid (normal) biochemical pattern; 12 (21.4%) showed abnormal biochemical pattern of euthyroid sick syndrome, subclinical hyperthyroid, and subclinical hypothyroid. Thirty (53.6%) of the T2DM were diagnosed less than five years ago. The value of TSH was increasing with the duration of diabetes but not in a statistically significant way. None of the T2DM showed overt hypothyroid or hyperthyroid test result. Conclusion: Thyroid function test may identify diabetics with altered thyroid hormone status that may impact on their metabolic control. Knowledge of the functional state of the thyroid gland can help in achieving a better metabolic control and attenuate the development of complications in T2DM. |
| first_indexed | 2024-04-14T04:48:07Z |
| format | Article |
| id | doaj.art-28a3810c977d486b94b7e4922a1266dc |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-04-14T04:48:07Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-28a3810c977d486b94b7e4922a1266dc2022-12-22T02:11:23ZengSAGE PublishingSAGE Open Medicine2050-31212022-05-011010.1177/20503121221097625Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based studyAhmed Kayode Jimoh0Muritala Segun Ghazali1Olajumoke Ajele Ogundeji2Babajide Adewoyin Adeleke3Oladimeji Gbadebo Ajani4Emmanuel Olusegun Gabriel-Alayode5Gbenga Omotade Popoola6Olufemi Sola Adediran7Department of Chemical Pathology, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Chemical Pathology, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Chemical Pathology, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Chemical Pathology, Federal Teaching Hospital, Ido-Ekiti, NigeriaDepartment of Medicine, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Family Medicine, Afe Babalola University, Ado-Ekiti, NigeriaDepartment of Epidemiology and Community Health, University of Ilorin, Ilorin, NigeriaDepartment of Medicine, Afe Babalola University, Ado-Ekiti, NigeriaObjectives: The thyroid gland produces hormones that have significant influence on carbohydrate metabolism; its disorders may affect carbohydrate metabolism in type 2 diabetic patients (T2DM) more than the non-diabetic (NDM) patients as reported in various studies. We determined the spectrum of thyroid function tests (TFTs) profile among T2DM in our rural health facility. Methods: T2DM patients and NDM patients were recruited for the study. The age, educational level, occupation, marital status, and duration of diabetes were extracted from interviewer’s administered questionnaire. The weight, height, body mass indices (BMIs), and the waist and hip circumferences were measured. Waist-hip ratios (WHR) were calculated for all participants. Venous blood was collected and assayed for free triiodothyronine (fT3), free thyroxine (fT4), and thyroid stimulating hormone (TSH) using a Chemiluminescence Immunoassay (CLIA) 2nd Generation Autoanalyzer. The mean, standard deviation, frequencies, and percentages were calculated for the variables. The student’s t-test and chi-square test were also determined as appropriate. Results: Seventy-eight patients made up of 56 T2DM and 22 NDM were evaluated in this study. Fifty-one were males while 27 were females; 67.9% and 59.1% of the female participants were T2DM and NDM, respectively. The WHR was significantly higher in T2DM than NDM (0.92 ± 0.05 versus 0.88 ± 0.06). The TSH was higher in T2DM than the NDM. Forty-four (78.6%) of the T2DM had euthyroid (normal) biochemical pattern; 12 (21.4%) showed abnormal biochemical pattern of euthyroid sick syndrome, subclinical hyperthyroid, and subclinical hypothyroid. Thirty (53.6%) of the T2DM were diagnosed less than five years ago. The value of TSH was increasing with the duration of diabetes but not in a statistically significant way. None of the T2DM showed overt hypothyroid or hyperthyroid test result. Conclusion: Thyroid function test may identify diabetics with altered thyroid hormone status that may impact on their metabolic control. Knowledge of the functional state of the thyroid gland can help in achieving a better metabolic control and attenuate the development of complications in T2DM.https://doi.org/10.1177/20503121221097625 |
| spellingShingle | Ahmed Kayode Jimoh Muritala Segun Ghazali Olajumoke Ajele Ogundeji Babajide Adewoyin Adeleke Oladimeji Gbadebo Ajani Emmanuel Olusegun Gabriel-Alayode Gbenga Omotade Popoola Olufemi Sola Adediran Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study SAGE Open Medicine |
| title | Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study |
| title_full | Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study |
| title_fullStr | Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study |
| title_full_unstemmed | Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study |
| title_short | Spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility, southwest Nigeria: A hospital-based study |
| title_sort | spectrum of thyroid function test among type 2 diabetic patients attending a rural health facility southwest nigeria a hospital based study |
| url | https://doi.org/10.1177/20503121221097625 |
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