The endocannabinoid system and stroke: A focused review
Stroke is an important cause of morbidity and mortality worldwide. Development of novel neuroprotectants is of paramount importance. This review seeks to summarize the recent evidence for the role of the endocannabinoid signaling system in stroke pathophysiology, as well as the evidence from preclin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Brain Circulation |
| Subjects: | |
| Online Access: | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2019;volume=5;issue=1;spage=1;epage=7;aulast=Kolb |
| _version_ | 1818500057958187008 |
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| author | Bradley Kolb Hamidreza Saber Hassan Fadel Gary Rajah |
| author_facet | Bradley Kolb Hamidreza Saber Hassan Fadel Gary Rajah |
| author_sort | Bradley Kolb |
| collection | DOAJ |
| description | Stroke is an important cause of morbidity and mortality worldwide. Development of novel neuroprotectants is of paramount importance. This review seeks to summarize the recent evidence for the role of the endocannabinoid signaling system in stroke pathophysiology, as well as the evidence from preclinical studies regarding the efficacy of cannabinoids as neuroprotective therapies in the treatment of stroke. Recent evidence from rodent models implicating cannabinoid 1 receptor (CB1R), cannabinoid 2 receptor (CB2R), and CB1R and CB2R co-antagonism as neuroprotective strategies in stroke are reviewed. Rodent evidence for the therapeutic role of the endocannabinoid system in treating poststroke depression is reviewed. Finally, evidence for the role of cannabidiol, a publicly available cannabinoid that does not bind directly to known endocannabinoid receptors, as a stroke neuroprotectant is also reviewed. The review closes with a consideration of the role of human cannabinoid abuse in stroke and considers future directions for research on endocannabinoid-based stroke therapeutics. |
| first_indexed | 2024-12-10T20:37:53Z |
| format | Article |
| id | doaj.art-28a448f5a48b48f19e4006891d4d5c34 |
| institution | Directory Open Access Journal |
| issn | 2394-8108 2455-4626 |
| language | English |
| last_indexed | 2024-12-10T20:37:53Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Brain Circulation |
| spelling | doaj.art-28a448f5a48b48f19e4006891d4d5c342022-12-22T01:34:28ZengWolters Kluwer Medknow PublicationsBrain Circulation2394-81082455-46262019-01-01511710.4103/bc.bc_29_18The endocannabinoid system and stroke: A focused reviewBradley KolbHamidreza SaberHassan FadelGary RajahStroke is an important cause of morbidity and mortality worldwide. Development of novel neuroprotectants is of paramount importance. This review seeks to summarize the recent evidence for the role of the endocannabinoid signaling system in stroke pathophysiology, as well as the evidence from preclinical studies regarding the efficacy of cannabinoids as neuroprotective therapies in the treatment of stroke. Recent evidence from rodent models implicating cannabinoid 1 receptor (CB1R), cannabinoid 2 receptor (CB2R), and CB1R and CB2R co-antagonism as neuroprotective strategies in stroke are reviewed. Rodent evidence for the therapeutic role of the endocannabinoid system in treating poststroke depression is reviewed. Finally, evidence for the role of cannabidiol, a publicly available cannabinoid that does not bind directly to known endocannabinoid receptors, as a stroke neuroprotectant is also reviewed. The review closes with a consideration of the role of human cannabinoid abuse in stroke and considers future directions for research on endocannabinoid-based stroke therapeutics.http://www.braincirculation.org/article.asp?issn=2394-8108;year=2019;volume=5;issue=1;spage=1;epage=7;aulast=KolbCannabidiolendocannabinoidneuroprotectionstroke |
| spellingShingle | Bradley Kolb Hamidreza Saber Hassan Fadel Gary Rajah The endocannabinoid system and stroke: A focused review Brain Circulation Cannabidiol endocannabinoid neuroprotection stroke |
| title | The endocannabinoid system and stroke: A focused review |
| title_full | The endocannabinoid system and stroke: A focused review |
| title_fullStr | The endocannabinoid system and stroke: A focused review |
| title_full_unstemmed | The endocannabinoid system and stroke: A focused review |
| title_short | The endocannabinoid system and stroke: A focused review |
| title_sort | endocannabinoid system and stroke a focused review |
| topic | Cannabidiol endocannabinoid neuroprotection stroke |
| url | http://www.braincirculation.org/article.asp?issn=2394-8108;year=2019;volume=5;issue=1;spage=1;epage=7;aulast=Kolb |
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