STIM and Orai1 variants in store-operated calcium entry
Store-operated Ca2+ is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the STIM family, STIM1 and STIM2. Store-dependent, STIM1-mo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00325/full |
| _version_ | 1811259577418645504 |
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| author | JUAN ANTONIO ROSADO Raquel eDiez Tarik eSmani Isaac eJardin |
| author_facet | JUAN ANTONIO ROSADO Raquel eDiez Tarik eSmani Isaac eJardin |
| author_sort | JUAN ANTONIO ROSADO |
| collection | DOAJ |
| description | Store-operated Ca2+ is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the STIM family, STIM1 and STIM2. Store-dependent, STIM1-modulated, channels include the Ca2+ release-activated Ca2+ (CRAC) channels, comprised of subunits of Orai proteins, as well as the store-operated Ca2+ (SOC) channels, involving Orai1 and members of the canonical transient receptor potential (TRPC) family of proteins. Recent studies have revealed the expression of splice variants of STIM1, STIM2 and Orai1 in different cell types. While certain variants are ubiquitously expressed, others, such as STIM1L, show a more restricted expression. The splice variants for STIM and Orai1 proteins exhibit significant functional differences and reveal that alternative splicing enhances the functional diversity of STIM1, STIM2 and Orai1 genes to modulate the dynamics of Ca2+ signals. |
| first_indexed | 2024-04-12T18:33:44Z |
| format | Article |
| id | doaj.art-28a4ec16c92b475d952714b11787ee89 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T18:33:44Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-28a4ec16c92b475d952714b11787ee892022-12-22T03:21:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122016-01-01610.3389/fphar.2015.00325180371STIM and Orai1 variants in store-operated calcium entryJUAN ANTONIO ROSADO0Raquel eDiez1Tarik eSmani2Isaac eJardin3University of ExtremaduraUniversity of ExtremaduraUniversity of SevilleUniversity of ExtremaduraStore-operated Ca2+ is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx is regulated by the filling state of the intracellular Ca2+ stores communicated to the plasma membrane channels by the proteins of the STIM family, STIM1 and STIM2. Store-dependent, STIM1-modulated, channels include the Ca2+ release-activated Ca2+ (CRAC) channels, comprised of subunits of Orai proteins, as well as the store-operated Ca2+ (SOC) channels, involving Orai1 and members of the canonical transient receptor potential (TRPC) family of proteins. Recent studies have revealed the expression of splice variants of STIM1, STIM2 and Orai1 in different cell types. While certain variants are ubiquitously expressed, others, such as STIM1L, show a more restricted expression. The splice variants for STIM and Orai1 proteins exhibit significant functional differences and reveal that alternative splicing enhances the functional diversity of STIM1, STIM2 and Orai1 genes to modulate the dynamics of Ca2+ signals.http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00325/fullOrai1STIM1STIM2Calcium entrysplice variants. |
| spellingShingle | JUAN ANTONIO ROSADO Raquel eDiez Tarik eSmani Isaac eJardin STIM and Orai1 variants in store-operated calcium entry Frontiers in Pharmacology Orai1 STIM1 STIM2 Calcium entry splice variants. |
| title | STIM and Orai1 variants in store-operated calcium entry |
| title_full | STIM and Orai1 variants in store-operated calcium entry |
| title_fullStr | STIM and Orai1 variants in store-operated calcium entry |
| title_full_unstemmed | STIM and Orai1 variants in store-operated calcium entry |
| title_short | STIM and Orai1 variants in store-operated calcium entry |
| title_sort | stim and orai1 variants in store operated calcium entry |
| topic | Orai1 STIM1 STIM2 Calcium entry splice variants. |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00325/full |
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