Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases
Summary: Patients with neurodegenerative diseases exhibit diminished basal forebrain (BF) volume compared to healthy individuals. However, it’s uncertain whether this difference is consistent between sexes. It has been reported that BF volume moderately atrophies during aging, but the effect of sex...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224002621 |
| _version_ | 1827353905273503744 |
|---|---|
| author | Yajun Shi Dong Cui Fengzhu Sun Zhen OuYang Ruhai Dou Qing Jiao Weifang Cao Guanghui Yu |
| author_facet | Yajun Shi Dong Cui Fengzhu Sun Zhen OuYang Ruhai Dou Qing Jiao Weifang Cao Guanghui Yu |
| author_sort | Yajun Shi |
| collection | DOAJ |
| description | Summary: Patients with neurodegenerative diseases exhibit diminished basal forebrain (BF) volume compared to healthy individuals. However, it’s uncertain whether this difference is consistent between sexes. It has been reported that BF volume moderately atrophies during aging, but the effect of sex on BF volume changes during the normal aging process remains unclear. In the cross-sectional study, we observed a significant reduction in BF volume in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) compared to Healthy Controls (HCs), especially in the Ch4 subregion. Notably, significant differences in BF volume between MCI and HCs were observed solely in the female group. Additionally, we identified asymmetrical atrophy in the left and right Ch4 subregions in female patients with AD. In the longitudinal analysis, we found that aging seemed to have a minimal impact on BF volume in males. Our study highlights the importance of considering sex as a research variable in brain science. |
| first_indexed | 2024-03-08T03:34:54Z |
| format | Article |
| id | doaj.art-28a56fa32b414444ac837a40aa80ee0b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T03:34:54Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-28a56fa32b414444ac837a40aa80ee0b2024-02-10T04:45:11ZengElsevieriScience2589-00422024-03-01273109041Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseasesYajun Shi0Dong Cui1Fengzhu Sun2Zhen OuYang3Ruhai Dou4Qing Jiao5Weifang Cao6Guanghui Yu7Department of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’ an, Shandong 271000, China; School of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’ an, Shandong 271016, ChinaDepartment of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’ an, Shandong 271000, China; School of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’ an, Shandong 271016, China; Corresponding authorDepartment of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’ an, Shandong 271000, China; School of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’ an, Shandong 271016, ChinaSchool of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’ an, Shandong 271016, China; Department of Radiology, Taian Municipal Hospital, Tai’ an, Shandong 271000, ChinaDepartment of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’ an, Shandong 271000, China; School of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’ an, Shandong 271016, ChinaDepartment of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’ an, Shandong 271000, China; School of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’ an, Shandong 271016, ChinaDepartment of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’ an, Shandong 271000, China; School of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’ an, Shandong 271016, ChinaDepartment of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’ an, Shandong 271000, China; School of Radiology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’ an, Shandong 271016, China; Corresponding authorSummary: Patients with neurodegenerative diseases exhibit diminished basal forebrain (BF) volume compared to healthy individuals. However, it’s uncertain whether this difference is consistent between sexes. It has been reported that BF volume moderately atrophies during aging, but the effect of sex on BF volume changes during the normal aging process remains unclear. In the cross-sectional study, we observed a significant reduction in BF volume in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) compared to Healthy Controls (HCs), especially in the Ch4 subregion. Notably, significant differences in BF volume between MCI and HCs were observed solely in the female group. Additionally, we identified asymmetrical atrophy in the left and right Ch4 subregions in female patients with AD. In the longitudinal analysis, we found that aging seemed to have a minimal impact on BF volume in males. Our study highlights the importance of considering sex as a research variable in brain science.http://www.sciencedirect.com/science/article/pii/S2589004224002621NeuroscienceClinical neuroscience |
| spellingShingle | Yajun Shi Dong Cui Fengzhu Sun Zhen OuYang Ruhai Dou Qing Jiao Weifang Cao Guanghui Yu Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases iScience Neuroscience Clinical neuroscience |
| title | Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases |
| title_full | Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases |
| title_fullStr | Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases |
| title_full_unstemmed | Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases |
| title_short | Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases |
| title_sort | exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases |
| topic | Neuroscience Clinical neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224002621 |
| work_keys_str_mv | AT yajunshi exploringsexualdimorphisminbasalforebrainvolumechangesduringagingandneurodegenerativediseases AT dongcui exploringsexualdimorphisminbasalforebrainvolumechangesduringagingandneurodegenerativediseases AT fengzhusun exploringsexualdimorphisminbasalforebrainvolumechangesduringagingandneurodegenerativediseases AT zhenouyang exploringsexualdimorphisminbasalforebrainvolumechangesduringagingandneurodegenerativediseases AT ruhaidou exploringsexualdimorphisminbasalforebrainvolumechangesduringagingandneurodegenerativediseases AT qingjiao exploringsexualdimorphisminbasalforebrainvolumechangesduringagingandneurodegenerativediseases AT weifangcao exploringsexualdimorphisminbasalforebrainvolumechangesduringagingandneurodegenerativediseases AT guanghuiyu exploringsexualdimorphisminbasalforebrainvolumechangesduringagingandneurodegenerativediseases |