The protective effects of vasopressin on experimental testicular torsion-detorsion in male rats
Introduction: Vasopressin is a potent vasoconstrictor. Vasopressin can reduce damages caused by ischemia-reperfusion. Objectives: The aim of this study was to evaluate the reducing effect of vasopressin on the damage caused by testicular torsion-detorsion in male rats. Materials and Methods: Fifty...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2019-01-01
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| Series: | Journal of Nephropharmacology |
| Subjects: | |
| Online Access: | http://jnephropharmacology.com/PDF/npj-8-10.pdf |
| _version_ | 1818038392517033984 |
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| author | Amin Hasanvand Fariba Ahmadizar Sadegh Ebrahimi-Ghalaei Fatemeh Beyranvand Reza Mohammadrezaei Khorramabadi Peyman Amanolahi Baharvand Abolfazl Abbaszadeh |
| author_facet | Amin Hasanvand Fariba Ahmadizar Sadegh Ebrahimi-Ghalaei Fatemeh Beyranvand Reza Mohammadrezaei Khorramabadi Peyman Amanolahi Baharvand Abolfazl Abbaszadeh |
| author_sort | Amin Hasanvand |
| collection | DOAJ |
| description | Introduction: Vasopressin is a potent vasoconstrictor. Vasopressin can reduce damages caused by
ischemia-reperfusion.
Objectives: The aim of this study was to evaluate the reducing effect of vasopressin on the damage
caused by testicular torsion-detorsion in male rats.
Materials and Methods: Fifty male rats were used in this study. The rats were divided randomly into
five groups (10 per group) as follows; 1) control group (without surgery), 2) sham group (surgery
without torsion-detorsion), 3) torsion-detorsion surgery without any treatment, 4) torsion-detorsion
surgery with vasopressin treatment (0.1 μg/kg), 5) torsion-detorsion surgery with vasopressin
treatment (0.2 μg/kg). After that, the rats were killed and subsequently the biochemical parameters
were measured by commercial kits. Histological changes were assessed by H&E staining.
Results: Using Kruskal Wallis test, we observed that the changes in the tissues of seminiferous tubes,
testosterone levels, glutathione (GSH) and thioredoxin enzymes in the studied groups (control,
sham, torsion-detorsion, torsion-detorsion with 0.1 μg/kg, torsion-detorsion with 0.2 μg/kg) were
statistically significant.
Conclusion: Intracellular mechanisms of vasopressin involved in the regulation of protective
mechanism and can reduce damages caused by ischemia-reperfusion. Vasopressin improves the
process of changes in the testicular seminiferous tubes of rats with torsion-detorsion. Moreover, it
also increases serum levels of testosterone, GSH and thioredoxin enzymes compared to the torsiondetorsion group |
| first_indexed | 2024-12-10T07:42:01Z |
| format | Article |
| id | doaj.art-28a622d66863455189101e48be6b0c6d |
| institution | Directory Open Access Journal |
| issn | 2345-4202 |
| language | English |
| last_indexed | 2024-12-10T07:42:01Z |
| publishDate | 2019-01-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropharmacology |
| spelling | doaj.art-28a622d66863455189101e48be6b0c6d2022-12-22T01:57:16ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropharmacology2345-42022019-01-0181101010.15171/npj.2019.10npj-20190112175252The protective effects of vasopressin on experimental testicular torsion-detorsion in male ratsAmin Hasanvand0Fariba Ahmadizar1Sadegh Ebrahimi-Ghalaei2Fatemeh Beyranvand3Reza Mohammadrezaei Khorramabadi4Peyman Amanolahi Baharvand5Abolfazl Abbaszadeh6Nutritional Health Research Center, Department of Pharmacology and toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, IranDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsStudent Research Committee, Lorestan University of Medical Sciences, Khorramabad, IranRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, IranStudent Research Committee, Lorestan University of Medical Sciences, Khorramabad, IranRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, IranDepartment of Surgery, Lorestan University of Medical Sciences, Khorramabad, IranIntroduction: Vasopressin is a potent vasoconstrictor. Vasopressin can reduce damages caused by ischemia-reperfusion. Objectives: The aim of this study was to evaluate the reducing effect of vasopressin on the damage caused by testicular torsion-detorsion in male rats. Materials and Methods: Fifty male rats were used in this study. The rats were divided randomly into five groups (10 per group) as follows; 1) control group (without surgery), 2) sham group (surgery without torsion-detorsion), 3) torsion-detorsion surgery without any treatment, 4) torsion-detorsion surgery with vasopressin treatment (0.1 μg/kg), 5) torsion-detorsion surgery with vasopressin treatment (0.2 μg/kg). After that, the rats were killed and subsequently the biochemical parameters were measured by commercial kits. Histological changes were assessed by H&E staining. Results: Using Kruskal Wallis test, we observed that the changes in the tissues of seminiferous tubes, testosterone levels, glutathione (GSH) and thioredoxin enzymes in the studied groups (control, sham, torsion-detorsion, torsion-detorsion with 0.1 μg/kg, torsion-detorsion with 0.2 μg/kg) were statistically significant. Conclusion: Intracellular mechanisms of vasopressin involved in the regulation of protective mechanism and can reduce damages caused by ischemia-reperfusion. Vasopressin improves the process of changes in the testicular seminiferous tubes of rats with torsion-detorsion. Moreover, it also increases serum levels of testosterone, GSH and thioredoxin enzymes compared to the torsiondetorsion grouphttp://jnephropharmacology.com/PDF/npj-8-10.pdfIschemia-reperfusionTesticular rotationTestisGlutathioneReactive oxygen speciesIschemia-reperfusion |
| spellingShingle | Amin Hasanvand Fariba Ahmadizar Sadegh Ebrahimi-Ghalaei Fatemeh Beyranvand Reza Mohammadrezaei Khorramabadi Peyman Amanolahi Baharvand Abolfazl Abbaszadeh The protective effects of vasopressin on experimental testicular torsion-detorsion in male rats Journal of Nephropharmacology Ischemia-reperfusion Testicular rotation Testis Glutathione Reactive oxygen species Ischemia-reperfusion |
| title | The protective effects of vasopressin on experimental
testicular torsion-detorsion in male rats |
| title_full | The protective effects of vasopressin on experimental
testicular torsion-detorsion in male rats |
| title_fullStr | The protective effects of vasopressin on experimental
testicular torsion-detorsion in male rats |
| title_full_unstemmed | The protective effects of vasopressin on experimental
testicular torsion-detorsion in male rats |
| title_short | The protective effects of vasopressin on experimental
testicular torsion-detorsion in male rats |
| title_sort | protective effects of vasopressin on experimental testicular torsion detorsion in male rats |
| topic | Ischemia-reperfusion Testicular rotation Testis Glutathione Reactive oxygen species Ischemia-reperfusion |
| url | http://jnephropharmacology.com/PDF/npj-8-10.pdf |
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