Sites for Dynamic Protein-Carbohydrate Interactions of O- and C-Linked Mannosides on the E. coli FimH Adhesin

Sites for Dynamic Protein-Carbohydrate Interactions of O- and C-Linked Mannosides on the E. coli FimH Adhesin

Antagonists of the Escherichia coli type-1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against acute and recurrent bacterial infections. In this study α-d-mannopyranosides O- or C-linked with an alkyl, alkene, alkyne, thioalkyl, amide, or...

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Detalles Bibliográficos
Main Authors: Mohamed Touaibia, Eva-Maria Krammer, Tze C. Shiao, Nao Yamakawa, Qingan Wang, Anja Glinschert, Alex Papadopoulos, Leila Mousavifar, Emmanuel Maes, Stefan Oscarson, Gerard Vergoten, Marc F. Lensink, René Roy, Julie Bouckaert
Formato: Artigo
Idioma:English
Publicado: MDPI AG 2017-07-01
Series:Molecules
Subjects:
C-glycosidic linkage
ortho-biphenyl mannose
FimH
anti-adhesive
uropathogenic E. coli
clamp loop
dynamic binding
Acceso en liña:https://www.mdpi.com/1420-3049/22/7/1101

Internet

https://www.mdpi.com/1420-3049/22/7/1101

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