Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate.

Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate.

The tumor suppressor p16Ink4a, encoded by the INK4a gene, is an inhibitor of cyclin D-dependent kinases 4 and 6, CDK4 and CDK6. This inhibition prevents the phosphorylation of the retinoblastoma protein (pRb), resulting in cellular senescence through inhibition of E2F-mediated transcription of S pha...

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Main Authors: Dong-Hong Lee, Eun-Jeong Yu, Joseph Aldahl, Julie Yang, Yongfeng He, Erika Hooker, Vien Le, Jiaqi Mi, Adam Olson, Huiqing Wu, Joseph Geradts, Guang Q Xiao, Mark L Gonzalgo, Robert D Cardiff, Zijie Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211153

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