Verification of the Field Productivity and Bioequivalence of a Medicinal Plant (<i>Polygonum multiflorum</i>) Developed Using an In Vitro Culture Method

Verification of the Field Productivity and Bioequivalence of a Medicinal Plant (<i>Polygonum multiflorum</i>) Developed Using an In Vitro Culture Method

<i>Polygonum multiflorum</i> Thunb. is a perennial plant that belongs to Polygonaceae. Root tissues are the main plant parts used as medicinal herbs in Korean oriental medicine. The <i>P. multiflorum</i> tuber is well known for its medicinal properties in Korean oriental medi...

Full description

Bibliographic Details
Main Authors:	Yong-Goo Kim, Richard Komakech, Dae Hui Jeong, Kwonseok Jeon, Yunmi Park, Tae Kyoung Lee, Ki Hyun Kim, Byeong Cheol Moon, Youngmin Kang
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	Plants
Subjects:	<i>Polygonum multiflorum</i> Thunb. medicinal plant field productivity bioequivalence validation
Online Access:	https://www.mdpi.com/2223-7747/9/10/1280

Similar Items

Study on the differential hepatotoxicity of raw polygonum multiflorum and polygonum multiflorum praeparata and its mechanism
by: Chaowen Huang, et al.
Published: (2024-04-01)

Research on polyphenols extraction from Polygonum multiflorum Thunb. roots
by: Quoc Le Pham Tan
Published: (2020-03-01)

Purification and Structural Characterization of Polysaccharides from <i>Polygonum multiflorum</i> Thunb. and Their Immunostimulatory Activity in RAW264.7 Cells
by: Yan Gou, et al.
Published: (2024-03-01)

Changes of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides During Processing of Polygonum multiflorum Thunb
by: Donglin Gu, et al.
Published: (2022-06-01)

Discovery of Hepatotoxic Equivalent Markers and Mechanism of <i>Polygonum multiflorum</i> Thunb. by Metabolomics Coupled with Molecular Docking
by: Yinhuan Zhang, et al.
Published: (2022-12-01)

Investigation of Liver Injury of Polygonum multiflorum Thunb. in Rats by Metabolomics and Traditional Approaches
by: Yun-Xia Li, et al.
Published: (2017-11-01)

<i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice
by: Ra-Yeong Choi, et al.
Published: (2021-07-01)

Polygonum multiflorum Thunb.: A Review on Chemical Analysis, Processing Mechanism, Quality Evaluation, and Hepatotoxicity
by: Yue Liu, et al.
Published: (2018-04-01)

Effect of Polygonum Multiflorum Thunb on liver fatty acid content in aging mice induced by D-galactose
by: Jiangquan Yang, et al.
Published: (2019-06-01)

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: <i>Polygonum multiflorum</i> Thunb as a Case Study
by: Shuaibing He, et al.
Published: (2019-10-01)

Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS
by: Yan Lin, et al.
Published: (2021-04-01)

Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models
by: Ninghui Ma, et al.
Published: (2021-06-01)

Metabolomic analysis revealed the edible and extended-application potential of specific Polygonum multiflorum tissues
by: Yudi Xu, et al.
Published: (2024-02-01)

Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in <i>Polygonum multiflorum</i> by UHPLC-PDA
by: Ying Xu, et al.
Published: (2022-01-01)

Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges
by: Yi Liu, et al.
Published: (2019-12-01)

2,3,5,4′- Tetrahydroxystilbene-2-O-β-D-glycoside Biosynthesis by Suspension Cells Cultures of Polygonum multiflorum Thunb and Production Enhancement by Methyl Jasmonate and Salicylic Acid
by: Li Shao, et al.
Published: (2012-02-01)

Effects of Polygonum multiflorum extract on DNA methylation and gene transcription in brain tissue of aging mice
by: ZOU Jiayi, et al.
Published: (2020-01-01)

Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to Polygonum multiflorum: A Cross-Sectional Cohort Study
by: Ying Huang, et al.
Published: (2020-11-01)

UHPLC-QQQ-MS/MS assay for the quantification of dianthrones as potential toxic markers of Polygonum multiflorum Thunb: applications for the standardization of traditional Chinese medicines (TCMs) with endogenous toxicity
by: Jian-Bo Yang, et al.
Published: (2021-07-01)

The Root of <i>Polygonum multiflorum</i> Thunb. Alleviates Non-Alcoholic Steatosis and Insulin Resistance in High Fat Diet-Fed Mice
by: Soonwoong Jung, et al.
Published: (2020-08-01)

A Network-Pharmacology-Combined Integrated Pharmacokinetic Strategy to Investigate the Mechanism of Potential Liver Injury due to <i>Polygonum multiflorum</i>
by: Zhixin Jia, et al.
Published: (2022-12-01)

Rapid discovery of the potential toxic compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-based metabolomics and correlation analysis
by: Han, Lifeng, et al.
Published: (2019)

Application of iTRAQ-Based Quantitative Proteomics Approach to Identify Deregulated Proteins Associated with Liver Toxicity Induced by Polygonum Multiflorum in Rats
by: Longfei Lin, et al.
Published: (2017-10-01)

Application of Ultra-High-Performance Liquid Chromatography Coupled with LTQ-Orbitrap Mass Spectrometry for the Qualitative and Quantitative Analysis of Polygonum multiflorum Thumb. and Its Processed Products
by: Teng-Hua Wang, et al.
Published: (2015-12-01)

Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study
by: Qin eDong, et al.
Published: (2015-10-01)

Comprehensive characterization of natural products of Polygonum multiflorum by cheminformatics analysis
by: Xiaowen Hu, et al.
Published: (2023-06-01)

Susceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans
by: Tu C, et al.
Published: (2021-03-01)

Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology
by: Yunfei Song, et al.
Published: (2020-11-01)

Water extract from processed Polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats
by: Wen Gu, et al.
Published: (2020-04-01)

Correlation between the redox activity of Polygonum multiflorum extract and its extraction technology with Chinese liquor (Baijiu): An electrochemistry-based study
by: Ying Su, et al.
Published: (2022-07-01)

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats
by: Miao Zhang, et al.
Published: (2018-05-01)

Molecular mechanism of polygonum multiflorum in the treatment of androgenic alopecia: based on bioinformatics and molecular docking method
by: Dongyu CHEN, et al.
Published: (2022-04-01)

Metabolomic study on idiosyncratic liver injury induced by different extracts of Polygonum multiflorum in rats integrated with pattern recognition and enriched pathways analysis
by: Chun-yu Li, et al.
Published: (2016-12-01)

Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
by: Wenping Tang, et al.
Published: (2022-09-01)

A New Perspective on Liver Injury by Traditional Chinese Herbs Such As Polygonum multiflorum: The Geographical Area of Harvest As an Important Contributory Factor
by: Longfei Lin, et al.
Published: (2017-06-01)

Susceptibility-Related Factor and Biomarkers of Dietary Supplement Polygonum multiflorum-Induced Liver Injury in Rats
by: Can Tu, et al.
Published: (2019-04-01)

Polygonum multiflorum root extract as a potential candidate for treatment of early graying hair
by: Nguyen Dinh Thang, et al.
Published: (2017-01-01)

Anti-inflammatory effects of trans-2,3,5,4′-tetrahydroxystilbene 2-O-β-glucopyranoside (THSG) from Polygonum multiflorum (PM) and hypoglycemic effect of cis-THSG enriched PM extract
by: Wenping Tang, et al.
Published: (2017-07-01)

A stepwise strategy integrating metabolomics and pseudotargeted spectrum–effect relationship to elucidate the potential hepatotoxic components in Polygonum multiflorum
by: Yunfei Song, et al.
Published: (2022-08-01)

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
by: Lifeng Han, et al.
Published: (2019-04-01)