A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations
Abstinence rates among smokers attempting to quit remain low despite the wide availability and accessibility of pharmacological smoking cessation treatments. In addition, the prevalence of cessation attempts and abstinence differs by individual-level social factors such as race and ethnicity. Clinic...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1103966/full |
| _version_ | 1797808866649440256 |
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| author | Elizabeth C. Prom-Wormley Jonathan L. Wells Lori Landes Amy N. Edmondson Mariam Sankoh Brendan Jamieson Kayla J. Delk Sanya Surya Shambhavi Bhati James Clifford |
| author_facet | Elizabeth C. Prom-Wormley Jonathan L. Wells Lori Landes Amy N. Edmondson Mariam Sankoh Brendan Jamieson Kayla J. Delk Sanya Surya Shambhavi Bhati James Clifford |
| author_sort | Elizabeth C. Prom-Wormley |
| collection | DOAJ |
| description | Abstinence rates among smokers attempting to quit remain low despite the wide availability and accessibility of pharmacological smoking cessation treatments. In addition, the prevalence of cessation attempts and abstinence differs by individual-level social factors such as race and ethnicity. Clinical treatment of nicotine dependence also continues to be challenged by individual-level variability in effectiveness to promote abstinence. The use of tailored smoking cessation strategies that incorporate information on individual-level social and genetic factors hold promise, although additional pharmacogenomic knowledge is still needed. In particular, genetic variants associated with pharmacological responses to smoking cessation treatment have generally been conducted in populations with participants that self-identify as White race or who are determined to be of European genetic ancestry. These results may not adequately capture the variability across all smokers as a result of understudied differences in allele frequencies across genetic ancestry populations. This suggests that much of the current pharmacogenetic study results for smoking cessation may not apply to all populations. Therefore, clinical application of pharmacogenetic results may exacerbate health inequities by racial and ethnic groups. This scoping review examines the extent to which racial, ethnic, and ancestral groups that experience differences in smoking rates and smoking cessation are represented in the existing body of published pharmacogenetic studies of smoking cessation. We will summarize results by race, ethnicity, and ancestry across pharmacological treatments and study designs. We will also explore current opportunities and challenges in conducting pharmacogenomic research on smoking cessation that encourages greater participant diversity, including practical barriers to clinical utilization of pharmacological smoking cessation treatment and clinical implementation of pharmacogenetic knowledge. |
| first_indexed | 2024-03-13T06:44:01Z |
| format | Article |
| id | doaj.art-28ab5b4ce2674837943a891a86fb3b27 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-13T06:44:01Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-28ab5b4ce2674837943a891a86fb3b272023-06-08T10:12:48ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-06-011410.3389/fgene.2023.11039661103966A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populationsElizabeth C. Prom-Wormley0Jonathan L. Wells1Lori Landes2Amy N. Edmondson3Mariam Sankoh4Brendan Jamieson5Kayla J. Delk6Sanya Surya7Shambhavi Bhati8James Clifford9Division of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United StatesDivision of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United StatesDivision of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Integrative Life Sciences, Virginia Commonwealth University, Richmond, VA, United StatesDivision of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United StatesDivision of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United StatesDivision of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United StatesDivision of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Public Health, Brody School of Medicine, East Carolina University, Greenville, United StatesAbstinence rates among smokers attempting to quit remain low despite the wide availability and accessibility of pharmacological smoking cessation treatments. In addition, the prevalence of cessation attempts and abstinence differs by individual-level social factors such as race and ethnicity. Clinical treatment of nicotine dependence also continues to be challenged by individual-level variability in effectiveness to promote abstinence. The use of tailored smoking cessation strategies that incorporate information on individual-level social and genetic factors hold promise, although additional pharmacogenomic knowledge is still needed. In particular, genetic variants associated with pharmacological responses to smoking cessation treatment have generally been conducted in populations with participants that self-identify as White race or who are determined to be of European genetic ancestry. These results may not adequately capture the variability across all smokers as a result of understudied differences in allele frequencies across genetic ancestry populations. This suggests that much of the current pharmacogenetic study results for smoking cessation may not apply to all populations. Therefore, clinical application of pharmacogenetic results may exacerbate health inequities by racial and ethnic groups. This scoping review examines the extent to which racial, ethnic, and ancestral groups that experience differences in smoking rates and smoking cessation are represented in the existing body of published pharmacogenetic studies of smoking cessation. We will summarize results by race, ethnicity, and ancestry across pharmacological treatments and study designs. We will also explore current opportunities and challenges in conducting pharmacogenomic research on smoking cessation that encourages greater participant diversity, including practical barriers to clinical utilization of pharmacological smoking cessation treatment and clinical implementation of pharmacogenetic knowledge.https://www.frontiersin.org/articles/10.3389/fgene.2023.1103966/fullsmoking cessationpharmacotherapygeneticsracialethniccigarettes |
| spellingShingle | Elizabeth C. Prom-Wormley Jonathan L. Wells Lori Landes Amy N. Edmondson Mariam Sankoh Brendan Jamieson Kayla J. Delk Sanya Surya Shambhavi Bhati James Clifford A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations Frontiers in Genetics smoking cessation pharmacotherapy genetics racial ethnic cigarettes |
| title | A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations |
| title_full | A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations |
| title_fullStr | A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations |
| title_full_unstemmed | A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations |
| title_short | A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations |
| title_sort | scoping review of smoking cessation pharmacogenetic studies to advance future research across racial ethnic and ancestral populations |
| topic | smoking cessation pharmacotherapy genetics racial ethnic cigarettes |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1103966/full |
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