Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid
Abstract Objectives This study aimed to investigate the gene expression of angiogenic marker in surgically treated jawbones and femur on a rat model administrated with zoledronic acid. Results No soft tissue fenestration or bone exposure was found in femur. Delayed soft tissue healing was found in b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-021-05900-5 |
| _version_ | 1818753922124218368 |
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| author | Jing Wen Li Jing Yi Wang Ru Qing Yu Lei Huo Li Wu Zheng |
| author_facet | Jing Wen Li Jing Yi Wang Ru Qing Yu Lei Huo Li Wu Zheng |
| author_sort | Jing Wen Li |
| collection | DOAJ |
| description | Abstract Objectives This study aimed to investigate the gene expression of angiogenic marker in surgically treated jawbones and femur on a rat model administrated with zoledronic acid. Results No soft tissue fenestration or bone exposure was found in femur. Delayed soft tissue healing was found in both ZA group (3 in mandible, 4 in maxilla) and control group (1 in mandible, 2 in maxilla), while exposed bone was found only in the ZA group (1 in maxilla, 2 in mandible). RT-PCR analysis demonstrated no significant difference in gene expression of angiogenetic markers between ZA-treated and control groups in femur and mandible. In the maxilla, the expression of VEGFA and VEGFR-2 in medium-term ZA group was significantly down-regulated compared with that in the control. The ZA treatment does not change significantly the expression of the angiogenic factors in femur and mandible, but significantly downregulates the expression in maxilla in this rat model. The angiogenesis inhibition may contribute to the development of MRONJ but does not play a key role. |
| first_indexed | 2024-12-18T05:15:03Z |
| format | Article |
| id | doaj.art-28afccbea2114c36bc82e6a14e03cf1b |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-18T05:15:03Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
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| series | BMC Research Notes |
| spelling | doaj.art-28afccbea2114c36bc82e6a14e03cf1b2022-12-21T21:19:48ZengBMCBMC Research Notes1756-05002022-01-011511610.1186/s13104-021-05900-5Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acidJing Wen Li0Jing Yi Wang1Ru Qing Yu2Lei Huo3Li Wu Zheng4Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong KongDiscipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong KongDiscipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong KongDepartment of Orthodontics, The First Affiliated Hospital of Zhengzhou UniversityDiscipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong KongAbstract Objectives This study aimed to investigate the gene expression of angiogenic marker in surgically treated jawbones and femur on a rat model administrated with zoledronic acid. Results No soft tissue fenestration or bone exposure was found in femur. Delayed soft tissue healing was found in both ZA group (3 in mandible, 4 in maxilla) and control group (1 in mandible, 2 in maxilla), while exposed bone was found only in the ZA group (1 in maxilla, 2 in mandible). RT-PCR analysis demonstrated no significant difference in gene expression of angiogenetic markers between ZA-treated and control groups in femur and mandible. In the maxilla, the expression of VEGFA and VEGFR-2 in medium-term ZA group was significantly down-regulated compared with that in the control. The ZA treatment does not change significantly the expression of the angiogenic factors in femur and mandible, but significantly downregulates the expression in maxilla in this rat model. The angiogenesis inhibition may contribute to the development of MRONJ but does not play a key role.https://doi.org/10.1186/s13104-021-05900-5Medication-related osteonecrosis of the jawZoledronic acidAnimal modelGene expressionAngiogenic markers |
| spellingShingle | Jing Wen Li Jing Yi Wang Ru Qing Yu Lei Huo Li Wu Zheng Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid BMC Research Notes Medication-related osteonecrosis of the jaw Zoledronic acid Animal model Gene expression Angiogenic markers |
| title | Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid |
| title_full | Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid |
| title_fullStr | Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid |
| title_full_unstemmed | Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid |
| title_short | Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid |
| title_sort | expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid |
| topic | Medication-related osteonecrosis of the jaw Zoledronic acid Animal model Gene expression Angiogenic markers |
| url | https://doi.org/10.1186/s13104-021-05900-5 |
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