Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice
Intracerebral hemorrhage (ICH) induces a strong hematoma-related neuroinflammatory reaction and alters peripheral immune homeostasis. Recent research has found that gut microbiota plays a role in neurodegeneration and autoimmune diseases by regulating immune homeostasis and neuroinflammation. Theref...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-05-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.647304/full |
| _version_ | 1818572565770141696 |
|---|---|
| author | Xiaobo Yu Guoyang Zhou Bo Shao Bo Shao Hang Zhou Chaoran Xu Feng Yan Lin Wang Gao Chen Jianru Li Xiongjie Fu |
| author_facet | Xiaobo Yu Guoyang Zhou Bo Shao Bo Shao Hang Zhou Chaoran Xu Feng Yan Lin Wang Gao Chen Jianru Li Xiongjie Fu |
| author_sort | Xiaobo Yu |
| collection | DOAJ |
| description | Intracerebral hemorrhage (ICH) induces a strong hematoma-related neuroinflammatory reaction and alters peripheral immune homeostasis. Recent research has found that gut microbiota plays a role in neurodegeneration and autoimmune diseases by regulating immune homeostasis and neuroinflammation. Therefore, we investigated the relationship between ICH, microbiota alteration, and immune responses after hematoma-induced acute brain injury. In our study, we used a mouse model of ICH, and 16S ribosomal RNA sequencing showed that ICH causes gut microbiota dysbiosis, which in turn affects ICH outcome through immune-mediated mechanisms. There was prominent reduced species diversity and microbiota overgrowth in the dysbiosis induced by ICH, which may reduce intestinal motility and increase gut permeability. In addition, recolonizing ICH mice with a normal health microbiota ameliorates functional deficits and neuroinflammation after ICH. Meanwhile, cell-tracking studies have demonstrated the migration of intestinal lymphocytes to the brain after ICH. In addition, therapeutic transplantation of fecal microbiota improves intestinal barrier damage. These results support the conclusion that the gut microbiome is a target of ICH-induced systemic alteration and is considered to have a substantial impact on ICH outcome. |
| first_indexed | 2024-12-14T18:58:51Z |
| format | Article |
| id | doaj.art-28b00b28516945f1b17a35222f4ec77c |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-14T18:58:51Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-28b00b28516945f1b17a35222f4ec77c2022-12-21T22:50:59ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-05-011210.3389/fmicb.2021.647304647304Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in MiceXiaobo Yu0Guoyang Zhou1Bo Shao2Bo Shao3Hang Zhou4Chaoran Xu5Feng Yan6Lin Wang7Gao Chen8Jianru Li9Xiongjie Fu10Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, The First People’s Hospital of Wenling, Wenling, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaIntracerebral hemorrhage (ICH) induces a strong hematoma-related neuroinflammatory reaction and alters peripheral immune homeostasis. Recent research has found that gut microbiota plays a role in neurodegeneration and autoimmune diseases by regulating immune homeostasis and neuroinflammation. Therefore, we investigated the relationship between ICH, microbiota alteration, and immune responses after hematoma-induced acute brain injury. In our study, we used a mouse model of ICH, and 16S ribosomal RNA sequencing showed that ICH causes gut microbiota dysbiosis, which in turn affects ICH outcome through immune-mediated mechanisms. There was prominent reduced species diversity and microbiota overgrowth in the dysbiosis induced by ICH, which may reduce intestinal motility and increase gut permeability. In addition, recolonizing ICH mice with a normal health microbiota ameliorates functional deficits and neuroinflammation after ICH. Meanwhile, cell-tracking studies have demonstrated the migration of intestinal lymphocytes to the brain after ICH. In addition, therapeutic transplantation of fecal microbiota improves intestinal barrier damage. These results support the conclusion that the gut microbiome is a target of ICH-induced systemic alteration and is considered to have a substantial impact on ICH outcome.https://www.frontiersin.org/articles/10.3389/fmicb.2021.647304/fullintracerebral hemorrhageneuroinflammationgut microbiotadysbiosisT cell |
| spellingShingle | Xiaobo Yu Guoyang Zhou Bo Shao Bo Shao Hang Zhou Chaoran Xu Feng Yan Lin Wang Gao Chen Jianru Li Xiongjie Fu Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice Frontiers in Microbiology intracerebral hemorrhage neuroinflammation gut microbiota dysbiosis T cell |
| title | Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice |
| title_full | Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice |
| title_fullStr | Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice |
| title_full_unstemmed | Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice |
| title_short | Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice |
| title_sort | gut microbiota dysbiosis induced by intracerebral hemorrhage aggravates neuroinflammation in mice |
| topic | intracerebral hemorrhage neuroinflammation gut microbiota dysbiosis T cell |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.647304/full |
| work_keys_str_mv | AT xiaoboyu gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT guoyangzhou gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT boshao gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT boshao gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT hangzhou gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT chaoranxu gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT fengyan gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT linwang gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT gaochen gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT jianruli gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice AT xiongjiefu gutmicrobiotadysbiosisinducedbyintracerebralhemorrhageaggravatesneuroinflammationinmice |