Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.
Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancien...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4764329?pdf=render |
| _version_ | 1818947053356580864 |
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| author | Denis V Axenov-Gribanov Irina V Voytsekhovskaya Bogdan T Tokovenko Eugeniy S Protasov Stanislav V Gamaiunov Yuriy V Rebets Andriy N Luzhetskyy Maxim A Timofeyev |
| author_facet | Denis V Axenov-Gribanov Irina V Voytsekhovskaya Bogdan T Tokovenko Eugeniy S Protasov Stanislav V Gamaiunov Yuriy V Rebets Andriy N Luzhetskyy Maxim A Timofeyev |
| author_sort | Denis V Axenov-Gribanov |
| collection | DOAJ |
| description | Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans. |
| first_indexed | 2024-12-20T08:24:47Z |
| format | Article |
| id | doaj.art-28b1308f543e4f3598c913197d721a1b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T08:24:47Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-28b1308f543e4f3598c913197d721a1b2022-12-21T19:46:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014921610.1371/journal.pone.0149216Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.Denis V Axenov-GribanovIrina V VoytsekhovskayaBogdan T TokovenkoEugeniy S ProtasovStanislav V GamaiunovYuriy V RebetsAndriy N LuzhetskyyMaxim A TimofeyevActinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.http://europepmc.org/articles/PMC4764329?pdf=render |
| spellingShingle | Denis V Axenov-Gribanov Irina V Voytsekhovskaya Bogdan T Tokovenko Eugeniy S Protasov Stanislav V Gamaiunov Yuriy V Rebets Andriy N Luzhetskyy Maxim A Timofeyev Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. PLoS ONE |
| title | Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. |
| title_full | Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. |
| title_fullStr | Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. |
| title_full_unstemmed | Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. |
| title_short | Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. |
| title_sort | actinobacteria isolated from an underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in siberia as sources of novel biologically active compounds |
| url | http://europepmc.org/articles/PMC4764329?pdf=render |
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