COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in Iran
Multiple sclerosis (MS) is a chronic, predominantly immune-mediated degenerative disease of the central nervous system. Due to prolonged use of immunomodulatory and immunosuppressive medications, vaccine hesitancy could be common among MS patients. Our main aim in the current study was to evaluate t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/1/135 |
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| author | Seyed Massood Nabavi Mehrnoosh Mehrabani Leila Ghalichi Mohammad Ali Nahayati Mehran Ghaffari Fereshteh Ashtari Seyed Ehsan Mohammadianinejad Shahedeh Karimi Leila Faghani Sepideh Yazdanbakhsh Abbas Najafian Koorosh Shahpasand Massoud Vosough |
| author_facet | Seyed Massood Nabavi Mehrnoosh Mehrabani Leila Ghalichi Mohammad Ali Nahayati Mehran Ghaffari Fereshteh Ashtari Seyed Ehsan Mohammadianinejad Shahedeh Karimi Leila Faghani Sepideh Yazdanbakhsh Abbas Najafian Koorosh Shahpasand Massoud Vosough |
| author_sort | Seyed Massood Nabavi |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic, predominantly immune-mediated degenerative disease of the central nervous system. Due to prolonged use of immunomodulatory and immunosuppressive medications, vaccine hesitancy could be common among MS patients. Our main aim in the current study was to evaluate the willingness and acceptability of COVID-19 vaccination in patients with MS. In our multicenter cross-sectional questionnaire-based clinical study, 892 patients completed the questionnaire between May to June 2021. The questionnaire consisted of demographic data, MS disease-related factors, history of COVID-19 infection/vaccination, and any existing comorbidities. Statistical analysis was performed using SPSS software version 19. Overall, 68% of the participants expressed willingness to be vaccinated. Major causes of vaccine refusal in our patients were the fear of reducing the efficacy of disease modifying drugs (DMDs) upon vaccination as well as distrusting the vaccines and overestimation bias in the power of their innate immunity and potential COVID-19 resistance. Some demographic factors affected vaccination enthusiasm in our study. Our findings did not show significant correlation between the age and comorbidity and vaccine willingness. Only one-third of our patients received their vaccine information from healthcare providers. The majority of them received these data from official broadcasting channels and social media. However, despite several concerns, the willingness of COVD-19 vaccination in the Iranian MS patients is remarkable. |
| first_indexed | 2024-03-10T00:22:31Z |
| format | Article |
| id | doaj.art-28b83aa9d3954de4b8f81d06b79bac36 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T00:22:31Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-28b83aa9d3954de4b8f81d06b79bac362023-11-23T15:40:01ZengMDPI AGVaccines2076-393X2022-01-0110113510.3390/vaccines10010135COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in IranSeyed Massood Nabavi0Mehrnoosh Mehrabani1Leila Ghalichi2Mohammad Ali Nahayati3Mehran Ghaffari4Fereshteh Ashtari5Seyed Ehsan Mohammadianinejad6Shahedeh Karimi7Leila Faghani8Sepideh Yazdanbakhsh9Abbas Najafian10Koorosh Shahpasand11Massoud Vosough12Arya Group for Treatment and Research in Multiple Sclerosis, Tehran 1435864464, IranArya Group for Treatment and Research in Multiple Sclerosis, Tehran 1435864464, IranArya Group for Treatment and Research in Multiple Sclerosis, Tehran 1435864464, IranNeurology Department, Mashhad University of Medical Sciences, Mashhad 9177948564, IranNeurology Department, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, IranNeurology Department, Isfahan University of Medical Sciences, Isfahan 73461-81746, IranNeurology Department, Jondishapour University of Medical Sciences, Ahvaz 15794-61357, IranArya Group for Treatment and Research in Multiple Sclerosis, Tehran 1435864464, IranArya Group for Treatment and Research in Multiple Sclerosis, Tehran 1435864464, IranArya Group for Treatment and Research in Multiple Sclerosis, Tehran 1435864464, IranArya Group for Treatment and Research in Multiple Sclerosis, Tehran 1435864464, IranDepartment of Brain and Cognitive Sciences, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran 1665659911, IranArya Group for Treatment and Research in Multiple Sclerosis, Tehran 1435864464, IranMultiple sclerosis (MS) is a chronic, predominantly immune-mediated degenerative disease of the central nervous system. Due to prolonged use of immunomodulatory and immunosuppressive medications, vaccine hesitancy could be common among MS patients. Our main aim in the current study was to evaluate the willingness and acceptability of COVID-19 vaccination in patients with MS. In our multicenter cross-sectional questionnaire-based clinical study, 892 patients completed the questionnaire between May to June 2021. The questionnaire consisted of demographic data, MS disease-related factors, history of COVID-19 infection/vaccination, and any existing comorbidities. Statistical analysis was performed using SPSS software version 19. Overall, 68% of the participants expressed willingness to be vaccinated. Major causes of vaccine refusal in our patients were the fear of reducing the efficacy of disease modifying drugs (DMDs) upon vaccination as well as distrusting the vaccines and overestimation bias in the power of their innate immunity and potential COVID-19 resistance. Some demographic factors affected vaccination enthusiasm in our study. Our findings did not show significant correlation between the age and comorbidity and vaccine willingness. Only one-third of our patients received their vaccine information from healthcare providers. The majority of them received these data from official broadcasting channels and social media. However, despite several concerns, the willingness of COVD-19 vaccination in the Iranian MS patients is remarkable.https://www.mdpi.com/2076-393X/10/1/135COVID-19 vaccinationmultiple sclerosisvaccine willingnessvaccine acceptabilityvaccine hesitancy |
| spellingShingle | Seyed Massood Nabavi Mehrnoosh Mehrabani Leila Ghalichi Mohammad Ali Nahayati Mehran Ghaffari Fereshteh Ashtari Seyed Ehsan Mohammadianinejad Shahedeh Karimi Leila Faghani Sepideh Yazdanbakhsh Abbas Najafian Koorosh Shahpasand Massoud Vosough COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in Iran Vaccines COVID-19 vaccination multiple sclerosis vaccine willingness vaccine acceptability vaccine hesitancy |
| title | COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in Iran |
| title_full | COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in Iran |
| title_fullStr | COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in Iran |
| title_full_unstemmed | COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in Iran |
| title_short | COVID-19 Vaccination Willingness and Acceptability in Multiple Sclerosis Patients: A Cross Sectional Study in Iran |
| title_sort | covid 19 vaccination willingness and acceptability in multiple sclerosis patients a cross sectional study in iran |
| topic | COVID-19 vaccination multiple sclerosis vaccine willingness vaccine acceptability vaccine hesitancy |
| url | https://www.mdpi.com/2076-393X/10/1/135 |
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