Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of Iran
Introduction: There is a high prevalence of hemoglobinopathies, including thalassemia, in Sistan and Baluchistan province of Iran. It is important to appropriately screen young adults to control the birth of new cases of thalassemia. In many less-equipped centers, this practice only relies on cell b...
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| Format: | Article |
| Language: | English |
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Zabol University of Medical sciences
2022-12-01
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| Series: | International Journal of Basic Science in Medicine |
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| Online Access: | https://ijbsm.zbmu.ac.ir/PDF/ijbsm-7-161.pdf |
| _version_ | 1797838963394740224 |
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| author | Omolbanin Sargazi-Aval Hojat Shahraki Alireza Khiabani Mahsa Rahgoshay Mohammad Mehdi Rahimi Ghahroudi |
| author_facet | Omolbanin Sargazi-Aval Hojat Shahraki Alireza Khiabani Mahsa Rahgoshay Mohammad Mehdi Rahimi Ghahroudi |
| author_sort | Omolbanin Sargazi-Aval |
| collection | DOAJ |
| description | Introduction: There is a high prevalence of hemoglobinopathies, including thalassemia, in Sistan and Baluchistan province of Iran. It is important to appropriately screen young adults to control the birth of new cases of thalassemia. In many less-equipped centers, this practice only relies on cell blood count. This study investigated the hematological parameters of young adults referring to the Central Laboratory of Sistan, Zabol, for premarital screening for thalassemia. Methods: This was a descriptive cross-sectional study conducted in Zabol, Sistan and Baluchistan province of Iran from August 2020 to August 2021. Complete blood count (CBC) parameters of 2926 young adults were collected using a Sysmex KX-21 device and were compared with available reference intervals according to the Clinical and Laboratory Standard Institute. Results: The means of women’s and men’s age were 38.84±16.32 and 36.64±14.14 years, respectively. The average values for each parameter in the studied population were red blood cell (RBC) (4.78±0.55), hemoglobin (13.19±2.46 g/dL), hematocrit (40.11±3.57%), mean corpuscular volume (MCV) (85.16±28.33), neutrophil (52.12±9.98), lymphocyte (37.84±9.03), mixed leukocytes (10.00±3.51), platelets (244.02±62.32). The mean values of hemoglobin (14.48±5.17 vs. 12.69±1.39 g/dL), hematocrit (43.01±3.89 vs. 38.97±3.45%), serum ferritin (115.4±74.3 vs. 69.20±12.36 g/dL), total iron-binding capacity (316.84±1.38 vs. 320.95±41.01, P=0.01), and serum iron (85.05±28.51 vs. 76.25±28.22, P=0.02) were significantly lower in women than in men. Out of 2,926 people who entered this study, 195 (6.66%) were suspected of having thalassemia because of their low MCV (71.61±7.33 fL) and mean corpuscular hemoglobin (MCH) (23.67±2.66 pg). Conclusion: The relatively low hemoglobin in females referring for premarital screening for thalassemia awakens healthcare experts to carefully examine these cases for the possibility of thalassemia minor after excluding other common possible reasons such as iron deficiency anemia using iron studies and hemoglobin electrophoresis. |
| first_indexed | 2024-04-09T15:50:31Z |
| format | Article |
| id | doaj.art-28b984b2b5e645cebb8ecb959877b09a |
| institution | Directory Open Access Journal |
| issn | 2476-664X |
| language | English |
| last_indexed | 2024-04-09T15:50:31Z |
| publishDate | 2022-12-01 |
| publisher | Zabol University of Medical sciences |
| record_format | Article |
| series | International Journal of Basic Science in Medicine |
| spelling | doaj.art-28b984b2b5e645cebb8ecb959877b09a2023-04-26T08:05:43ZengZabol University of Medical sciencesInternational Journal of Basic Science in Medicine2476-664X2022-12-017416116510.34172/ijbsm.2022.28ijbsm-23582Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of IranOmolbanin Sargazi-Aval0Hojat Shahraki1Alireza Khiabani2Mahsa Rahgoshay3Mohammad Mehdi Rahimi Ghahroudi4Faculty of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, IranDepartment of Laboratory Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Bam University of Medical Sciences, Bam, IranDepartment of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, IranStudent Research Committee, School of Allied Medical Sciences, Zabol University of Medical Sciences, Zabol, IranIntroduction: There is a high prevalence of hemoglobinopathies, including thalassemia, in Sistan and Baluchistan province of Iran. It is important to appropriately screen young adults to control the birth of new cases of thalassemia. In many less-equipped centers, this practice only relies on cell blood count. This study investigated the hematological parameters of young adults referring to the Central Laboratory of Sistan, Zabol, for premarital screening for thalassemia. Methods: This was a descriptive cross-sectional study conducted in Zabol, Sistan and Baluchistan province of Iran from August 2020 to August 2021. Complete blood count (CBC) parameters of 2926 young adults were collected using a Sysmex KX-21 device and were compared with available reference intervals according to the Clinical and Laboratory Standard Institute. Results: The means of women’s and men’s age were 38.84±16.32 and 36.64±14.14 years, respectively. The average values for each parameter in the studied population were red blood cell (RBC) (4.78±0.55), hemoglobin (13.19±2.46 g/dL), hematocrit (40.11±3.57%), mean corpuscular volume (MCV) (85.16±28.33), neutrophil (52.12±9.98), lymphocyte (37.84±9.03), mixed leukocytes (10.00±3.51), platelets (244.02±62.32). The mean values of hemoglobin (14.48±5.17 vs. 12.69±1.39 g/dL), hematocrit (43.01±3.89 vs. 38.97±3.45%), serum ferritin (115.4±74.3 vs. 69.20±12.36 g/dL), total iron-binding capacity (316.84±1.38 vs. 320.95±41.01, P=0.01), and serum iron (85.05±28.51 vs. 76.25±28.22, P=0.02) were significantly lower in women than in men. Out of 2,926 people who entered this study, 195 (6.66%) were suspected of having thalassemia because of their low MCV (71.61±7.33 fL) and mean corpuscular hemoglobin (MCH) (23.67±2.66 pg). Conclusion: The relatively low hemoglobin in females referring for premarital screening for thalassemia awakens healthcare experts to carefully examine these cases for the possibility of thalassemia minor after excluding other common possible reasons such as iron deficiency anemia using iron studies and hemoglobin electrophoresis.https://ijbsm.zbmu.ac.ir/PDF/ijbsm-7-161.pdfhemoglobinopathy screeningthalassemianormal ranges |
| spellingShingle | Omolbanin Sargazi-Aval Hojat Shahraki Alireza Khiabani Mahsa Rahgoshay Mohammad Mehdi Rahimi Ghahroudi Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of Iran International Journal of Basic Science in Medicine hemoglobinopathy screening thalassemia normal ranges |
| title | Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of Iran |
| title_full | Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of Iran |
| title_fullStr | Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of Iran |
| title_full_unstemmed | Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of Iran |
| title_short | Premarital Screening for Thalassemia Among Young Adults: A Study in Zabol, Sistan and Baluchistan Province of Iran |
| title_sort | premarital screening for thalassemia among young adults a study in zabol sistan and baluchistan province of iran |
| topic | hemoglobinopathy screening thalassemia normal ranges |
| url | https://ijbsm.zbmu.ac.ir/PDF/ijbsm-7-161.pdf |
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