Radioprotective properties of nutraceutical Gonebazol: In vivo study
BACKGROUND: In vitro investigation of radioprotective properties of novel nutraceutical Gonebazol (Biofarm, Belgrade) has displayed its remarkable potential to reduce chromosomal aberrations and micronuclei induced by x rays. The goal of this study was to evaluate its protective properties in vivo....
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| Format: | Article |
| Language: | English |
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Institute of Oncology, Sremska Kamenica, Serbia
2006-01-01
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| Series: | Archive of Oncology |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-7310/2006/0354-73100602015J.pdf |
| _version_ | 1818516287962218496 |
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| author | Joksić Gordana Ilić Nevenka Spasojević-Tišma Vera |
| author_facet | Joksić Gordana Ilić Nevenka Spasojević-Tišma Vera |
| author_sort | Joksić Gordana |
| collection | DOAJ |
| description | BACKGROUND: In vitro investigation of radioprotective properties of novel nutraceutical Gonebazol (Biofarm, Belgrade) has displayed its remarkable potential to reduce chromosomal aberrations and micronuclei induced by x rays. The goal of this study was to evaluate its protective properties in vivo. For this purpose, a group of medical staff performing invasive radiological diagnostics, that was identified to carry dicentrics in their lymphocytes, was selected for further monitoring. They consumed this nutraceutical for 3 weeks, 2 x 10 g per day (2 x 2 teaspoons dissolved in a glass of water). METHODS: Hematological parameters, chromosomal aberrations and micronucleus frequency were examined at the beginning of monitoring, on day 10 and 21 of the treatment. RESULTS: In the course of three weeks the incidence of chromosomal aberrations and micronuclei was significantly reduced (50%-80%), absolute number of granulocytes was lowered whereas the number of monocytes significantly was enhanced. This study has revealed that nutraceutic posses immunomodulatory properties seen as an improving monocyte-macrophage activity, which inversely correlates with incidence of lymphocyte micronuclei (r=0.75, p<0.05). CONCLUSION: Observed finding could be of particular importance in reducing cumulative effects of ionizing radiation in radiosensitive tissues and in preventing adverse health effects. No side effects were evidenced. Mechanisms of its immunomodulatory effects should be further examined. |
| first_indexed | 2024-12-11T00:40:04Z |
| format | Article |
| id | doaj.art-28bb9cc2c19145669f378461430feb99 |
| institution | Directory Open Access Journal |
| issn | 0354-7310 |
| language | English |
| last_indexed | 2024-12-11T00:40:04Z |
| publishDate | 2006-01-01 |
| publisher | Institute of Oncology, Sremska Kamenica, Serbia |
| record_format | Article |
| series | Archive of Oncology |
| spelling | doaj.art-28bb9cc2c19145669f378461430feb992022-12-22T01:26:56ZengInstitute of Oncology, Sremska Kamenica, SerbiaArchive of Oncology0354-73102006-01-01141-2151810.2298/AOO0602015JRadioprotective properties of nutraceutical Gonebazol: In vivo studyJoksić GordanaIlić NevenkaSpasojević-Tišma VeraBACKGROUND: In vitro investigation of radioprotective properties of novel nutraceutical Gonebazol (Biofarm, Belgrade) has displayed its remarkable potential to reduce chromosomal aberrations and micronuclei induced by x rays. The goal of this study was to evaluate its protective properties in vivo. For this purpose, a group of medical staff performing invasive radiological diagnostics, that was identified to carry dicentrics in their lymphocytes, was selected for further monitoring. They consumed this nutraceutical for 3 weeks, 2 x 10 g per day (2 x 2 teaspoons dissolved in a glass of water). METHODS: Hematological parameters, chromosomal aberrations and micronucleus frequency were examined at the beginning of monitoring, on day 10 and 21 of the treatment. RESULTS: In the course of three weeks the incidence of chromosomal aberrations and micronuclei was significantly reduced (50%-80%), absolute number of granulocytes was lowered whereas the number of monocytes significantly was enhanced. This study has revealed that nutraceutic posses immunomodulatory properties seen as an improving monocyte-macrophage activity, which inversely correlates with incidence of lymphocyte micronuclei (r=0.75, p<0.05). CONCLUSION: Observed finding could be of particular importance in reducing cumulative effects of ionizing radiation in radiosensitive tissues and in preventing adverse health effects. No side effects were evidenced. Mechanisms of its immunomodulatory effects should be further examined.http://www.doiserbia.nb.rs/img/doi/0354-7310/2006/0354-73100602015J.pdfradiationionizingoccupational exposureradiation-protective agentsdietary supplementschromosome aberrations |
| spellingShingle | Joksić Gordana Ilić Nevenka Spasojević-Tišma Vera Radioprotective properties of nutraceutical Gonebazol: In vivo study Archive of Oncology radiation ionizing occupational exposure radiation-protective agents dietary supplements chromosome aberrations |
| title | Radioprotective properties of nutraceutical Gonebazol: In vivo study |
| title_full | Radioprotective properties of nutraceutical Gonebazol: In vivo study |
| title_fullStr | Radioprotective properties of nutraceutical Gonebazol: In vivo study |
| title_full_unstemmed | Radioprotective properties of nutraceutical Gonebazol: In vivo study |
| title_short | Radioprotective properties of nutraceutical Gonebazol: In vivo study |
| title_sort | radioprotective properties of nutraceutical gonebazol in vivo study |
| topic | radiation ionizing occupational exposure radiation-protective agents dietary supplements chromosome aberrations |
| url | http://www.doiserbia.nb.rs/img/doi/0354-7310/2006/0354-73100602015J.pdf |
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