Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy

The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and an IL-2 mutant that avoids off-target side eff...

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Bibliographic Details
Main Authors: Eric Lazear, Reza Ghasemi, Sarah M. Hein, John Westwick, Dan Watkins, Daved H. Fremont, Alexander Sasha Krupnick
Format: Article
Language:English
Published: Taylor & Francis Group 2017-02-01
Series:OncoImmunology
Subjects:
cytokine
cytotoxic lymphocytes
immunotargeting
immunotherapy
interleukin-2 (il-2)
natural killer cell (nk)
nkg2d
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1265721

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