Immunomodulatory Properties of Natural Extracts and Compounds Derived from <i>Bidens pilosa</i> L.: Literature Review
<i>Bidens pilosa</i> L. has been used in different parts of the world mainly to treat diseases associated with immune response disorders, such as autoimmunity, cancer, allergies, and infectious diseases. The medicinal properties of this plant are attributed to its chemical components. Ne...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/5/1491 |
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| author | Xandy Melissa Rodríguez-Mesa Leonardo Andres Contreras Bolaños Antonio Mejía Luis Miguel Pombo Geison Modesti Costa Sandra Paola Santander González |
| author_facet | Xandy Melissa Rodríguez-Mesa Leonardo Andres Contreras Bolaños Antonio Mejía Luis Miguel Pombo Geison Modesti Costa Sandra Paola Santander González |
| author_sort | Xandy Melissa Rodríguez-Mesa |
| collection | DOAJ |
| description | <i>Bidens pilosa</i> L. has been used in different parts of the world mainly to treat diseases associated with immune response disorders, such as autoimmunity, cancer, allergies, and infectious diseases. The medicinal properties of this plant are attributed to its chemical components. Nevertheless, there is little conclusive evidence that describes the immunomodulatory activity of this plant. In this review, a systematic search was carried out in the PubMed-NLM, EBSCO Host and BVS databases focused on the pre-clinical scientific evidence of the immunomodulatory properties of <i>B. pilosa</i>. A total of 314 articles were found and only 23 were selected. The results show that the compounds or extracts of <i>Bidens</i> modulate the immune cells. This activity was associated with the presence of phenolic compounds and flavonoids that control proliferation, oxidative stress, phagocytosis, and the production of cytokines of different cells. Most of the scientific information analyzed in this paper supports the potential use of <i>B. pilosa</i> mainly as an anti-inflammatory, antioxidant, antitumoral, antidiabetic, and antimicrobial immune response modulator. It is necessary that this biological activity be corroborated through the design of specialized clinical trials that demonstrate the effectiveness in the treatment of autoimmune diseases, chronic inflammation, and infectious diseases. Until now there has only been one clinical trial in phase I and II associated with the anti-inflammatory activity of <i>Bidens</i> in mucositis. |
| first_indexed | 2024-03-11T03:24:08Z |
| format | Article |
| id | doaj.art-28bcfc478da1421a8f0a3da67d528028 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T03:24:08Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-28bcfc478da1421a8f0a3da67d5280282023-11-18T02:52:21ZengMDPI AGPharmaceutics1999-49232023-05-01155149110.3390/pharmaceutics15051491Immunomodulatory Properties of Natural Extracts and Compounds Derived from <i>Bidens pilosa</i> L.: Literature ReviewXandy Melissa Rodríguez-Mesa0Leonardo Andres Contreras Bolaños1Antonio Mejía2Luis Miguel Pombo3Geison Modesti Costa4Sandra Paola Santander González5Phytoimmunomodulation Research Group, Juan N. Corpas University Foundation, Bogotá Carrera 111 #159A-61, Bogota 111321, ColombiaPhytoimmunomodulation Research Group, Juan N. Corpas University Foundation, Bogotá Carrera 111 #159A-61, Bogota 111321, ColombiaPhytoimmunomodulation Research Group, Juan N. Corpas University Foundation, Bogotá Carrera 111 #159A-61, Bogota 111321, ColombiaPlant Pharmacology and Alternative Therapeutics, Juan N. Corpas University Foundation, Bogotá Carrera 111 #159A-61, Bogota 111321, ColombiaPhytochemistry Research Group (GIFUJ), Pontificia Universidad Javeriana, Bogotá Carrera 7 #40-62, Bogota 110231, ColombiaPhytoimmunomodulation Research Group, Juan N. Corpas University Foundation, Bogotá Carrera 111 #159A-61, Bogota 111321, Colombia<i>Bidens pilosa</i> L. has been used in different parts of the world mainly to treat diseases associated with immune response disorders, such as autoimmunity, cancer, allergies, and infectious diseases. The medicinal properties of this plant are attributed to its chemical components. Nevertheless, there is little conclusive evidence that describes the immunomodulatory activity of this plant. In this review, a systematic search was carried out in the PubMed-NLM, EBSCO Host and BVS databases focused on the pre-clinical scientific evidence of the immunomodulatory properties of <i>B. pilosa</i>. A total of 314 articles were found and only 23 were selected. The results show that the compounds or extracts of <i>Bidens</i> modulate the immune cells. This activity was associated with the presence of phenolic compounds and flavonoids that control proliferation, oxidative stress, phagocytosis, and the production of cytokines of different cells. Most of the scientific information analyzed in this paper supports the potential use of <i>B. pilosa</i> mainly as an anti-inflammatory, antioxidant, antitumoral, antidiabetic, and antimicrobial immune response modulator. It is necessary that this biological activity be corroborated through the design of specialized clinical trials that demonstrate the effectiveness in the treatment of autoimmune diseases, chronic inflammation, and infectious diseases. Until now there has only been one clinical trial in phase I and II associated with the anti-inflammatory activity of <i>Bidens</i> in mucositis.https://www.mdpi.com/1999-4923/15/5/1491<i>Bidens pilosa</i> L.immunomodulationphytochemistrytraditional medicinephytotherapy |
| spellingShingle | Xandy Melissa Rodríguez-Mesa Leonardo Andres Contreras Bolaños Antonio Mejía Luis Miguel Pombo Geison Modesti Costa Sandra Paola Santander González Immunomodulatory Properties of Natural Extracts and Compounds Derived from <i>Bidens pilosa</i> L.: Literature Review Pharmaceutics <i>Bidens pilosa</i> L. immunomodulation phytochemistry traditional medicine phytotherapy |
| title | Immunomodulatory Properties of Natural Extracts and Compounds Derived from <i>Bidens pilosa</i> L.: Literature Review |
| title_full | Immunomodulatory Properties of Natural Extracts and Compounds Derived from <i>Bidens pilosa</i> L.: Literature Review |
| title_fullStr | Immunomodulatory Properties of Natural Extracts and Compounds Derived from <i>Bidens pilosa</i> L.: Literature Review |
| title_full_unstemmed | Immunomodulatory Properties of Natural Extracts and Compounds Derived from <i>Bidens pilosa</i> L.: Literature Review |
| title_short | Immunomodulatory Properties of Natural Extracts and Compounds Derived from <i>Bidens pilosa</i> L.: Literature Review |
| title_sort | immunomodulatory properties of natural extracts and compounds derived from i bidens pilosa i l literature review |
| topic | <i>Bidens pilosa</i> L. immunomodulation phytochemistry traditional medicine phytotherapy |
| url | https://www.mdpi.com/1999-4923/15/5/1491 |
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