Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit
Neuroinflammation is a complex inflammatory process in the central nervous system, which is sought to play an important defensive role against various pathogens, toxins or factors that induce neurodegeneration. The onset of neurodegenerative diseases and various microbial infections are counted as s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00276/full |
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| author | Abolghasem Tohidpour Andrey V. Morgun Andrey V. Morgun Elizaveta B. Boitsova Elizaveta B. Boitsova Natalia A. Malinovskaya Galina P. Martynova Elena D. Khilazheva Natalia V. Kopylevich Galina E. Gertsog Alla B. Salmina |
| author_facet | Abolghasem Tohidpour Andrey V. Morgun Andrey V. Morgun Elizaveta B. Boitsova Elizaveta B. Boitsova Natalia A. Malinovskaya Galina P. Martynova Elena D. Khilazheva Natalia V. Kopylevich Galina E. Gertsog Alla B. Salmina |
| author_sort | Abolghasem Tohidpour |
| collection | DOAJ |
| description | Neuroinflammation is a complex inflammatory process in the central nervous system, which is sought to play an important defensive role against various pathogens, toxins or factors that induce neurodegeneration. The onset of neurodegenerative diseases and various microbial infections are counted as stimuli that can challenge the host immune system and trigger the development of neuroinflammation. The homeostatic nature of neuroinflammation is essential to maintain the neuroplasticity. Neuroinflammation is regulated by the activity of neuronal, glial, and endothelial cells within the neurovascular unit, which serves as a “platform” for the coordinated action of pro- and anti-inflammatory mechanisms. Production of inflammatory mediators (cytokines, chemokines, reactive oxygen species) by brain resident cells or cells migrating from the peripheral blood, results in the impairment of blood-brain barrier integrity, thereby further affecting the course of local inflammation. In this review, we analyzed the most recent data on the central nervous system inflammation and focused on major mechanisms of neurovascular unit dysfunction caused by neuroinflammation and infections. |
| first_indexed | 2024-04-12T20:12:19Z |
| format | Article |
| id | doaj.art-28bdc40daa4a49888b854b5e61b8f14b |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-12T20:12:19Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-28bdc40daa4a49888b854b5e61b8f14b2022-12-22T03:18:12ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882017-06-01710.3389/fcimb.2017.00276272761Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular UnitAbolghasem Tohidpour0Andrey V. Morgun1Andrey V. Morgun2Elizaveta B. Boitsova3Elizaveta B. Boitsova4Natalia A. Malinovskaya5Galina P. Martynova6Elena D. Khilazheva7Natalia V. Kopylevich8Galina E. Gertsog9Alla B. Salmina10Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaResearch Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaDepartment of Paediatrics, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaResearch Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaDepartment of Children Infectious Diseases, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaResearch Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaDepartment of Children Infectious Diseases, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaResearch Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaResearch Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaResearch Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaResearch Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyKrasnoyarsk, RussiaNeuroinflammation is a complex inflammatory process in the central nervous system, which is sought to play an important defensive role against various pathogens, toxins or factors that induce neurodegeneration. The onset of neurodegenerative diseases and various microbial infections are counted as stimuli that can challenge the host immune system and trigger the development of neuroinflammation. The homeostatic nature of neuroinflammation is essential to maintain the neuroplasticity. Neuroinflammation is regulated by the activity of neuronal, glial, and endothelial cells within the neurovascular unit, which serves as a “platform” for the coordinated action of pro- and anti-inflammatory mechanisms. Production of inflammatory mediators (cytokines, chemokines, reactive oxygen species) by brain resident cells or cells migrating from the peripheral blood, results in the impairment of blood-brain barrier integrity, thereby further affecting the course of local inflammation. In this review, we analyzed the most recent data on the central nervous system inflammation and focused on major mechanisms of neurovascular unit dysfunction caused by neuroinflammation and infections.http://journal.frontiersin.org/article/10.3389/fcimb.2017.00276/fullinfectious diseasesblood-brain barrierimmune responseneurodegenerationbrain development |
| spellingShingle | Abolghasem Tohidpour Andrey V. Morgun Andrey V. Morgun Elizaveta B. Boitsova Elizaveta B. Boitsova Natalia A. Malinovskaya Galina P. Martynova Elena D. Khilazheva Natalia V. Kopylevich Galina E. Gertsog Alla B. Salmina Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit Frontiers in Cellular and Infection Microbiology infectious diseases blood-brain barrier immune response neurodegeneration brain development |
| title | Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit |
| title_full | Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit |
| title_fullStr | Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit |
| title_full_unstemmed | Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit |
| title_short | Neuroinflammation and Infection: Molecular Mechanisms Associated with Dysfunction of Neurovascular Unit |
| title_sort | neuroinflammation and infection molecular mechanisms associated with dysfunction of neurovascular unit |
| topic | infectious diseases blood-brain barrier immune response neurodegeneration brain development |
| url | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00276/full |
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