Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed?
While the increased arrhythmic tendency during acute COVID-19 infection is recognised, the long-term cardiac electrophysiological complications are less well known. There are a high number of patients reporting ongoing symptoms post-infection, termed long COVID. A recent hypothesis is that long COVI...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.860198/full |
| _version_ | 1831767584648724480 |
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| author | Karan R. Chadda Ellen E. Blakey Christopher L. -H. Huang Christopher L. -H. Huang Kamalan Jeevaratnam Kamalan Jeevaratnam |
| author_facet | Karan R. Chadda Ellen E. Blakey Christopher L. -H. Huang Christopher L. -H. Huang Kamalan Jeevaratnam Kamalan Jeevaratnam |
| author_sort | Karan R. Chadda |
| collection | DOAJ |
| description | While the increased arrhythmic tendency during acute COVID-19 infection is recognised, the long-term cardiac electrophysiological complications are less well known. There are a high number of patients reporting ongoing symptoms post-infection, termed long COVID. A recent hypothesis is that long COVID symptoms could be attributed to dysautonomia, defined as malfunction of the autonomic nervous system (ANS). The most prevalent cardiovascular dysautonomia amongst young people is postural orthostatic tachycardia syndrome (POTS). Numerous reports have described the development of POTS as part of long COVID. Possible underlying mechanisms, although not mutually exclusive or exhaustive, include hypovolaemia, neurotropism, inflammation and autoimmunity. Treatment options for POTS and other long COVID symptoms are currently limited. Future research studies should aim to elucidate the underlying mechanisms of dysautonomia to enable the development of targeted therapies. Furthermore, it is important to educate healthcare professionals to recognise complications and conditions arising from COVID-19, such as POTS, to allow prompt diagnosis and access to early treatment. |
| first_indexed | 2024-12-22T06:44:53Z |
| format | Article |
| id | doaj.art-28bfc4349fcf4a6a905f5dff1ac55579 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-22T06:44:53Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-28bfc4349fcf4a6a905f5dff1ac555792022-12-21T18:35:19ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-03-01910.3389/fcvm.2022.860198860198Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed?Karan R. Chadda0Ellen E. Blakey1Christopher L. -H. Huang2Christopher L. -H. Huang3Kamalan Jeevaratnam4Kamalan Jeevaratnam5Cambridge University Hospitals NHS Foundation Trust, Cambridge, United KingdomCambridge University Hospitals NHS Foundation Trust, Cambridge, United KingdomPhysiological Laboratory, University of Cambridge, Cambridge, United KingdomDepartment of Biochemistry, University of Cambridge, Cambridge, United KingdomPhysiological Laboratory, University of Cambridge, Cambridge, United KingdomFaculty of Health and Medical Sciences, University of Surrey, Guildford, United KingdomWhile the increased arrhythmic tendency during acute COVID-19 infection is recognised, the long-term cardiac electrophysiological complications are less well known. There are a high number of patients reporting ongoing symptoms post-infection, termed long COVID. A recent hypothesis is that long COVID symptoms could be attributed to dysautonomia, defined as malfunction of the autonomic nervous system (ANS). The most prevalent cardiovascular dysautonomia amongst young people is postural orthostatic tachycardia syndrome (POTS). Numerous reports have described the development of POTS as part of long COVID. Possible underlying mechanisms, although not mutually exclusive or exhaustive, include hypovolaemia, neurotropism, inflammation and autoimmunity. Treatment options for POTS and other long COVID symptoms are currently limited. Future research studies should aim to elucidate the underlying mechanisms of dysautonomia to enable the development of targeted therapies. Furthermore, it is important to educate healthcare professionals to recognise complications and conditions arising from COVID-19, such as POTS, to allow prompt diagnosis and access to early treatment.https://www.frontiersin.org/articles/10.3389/fcvm.2022.860198/fulllong COVIDtachycardiapostural orthostatic tachycardia syndromedysautonomiaarrhythmia |
| spellingShingle | Karan R. Chadda Ellen E. Blakey Christopher L. -H. Huang Christopher L. -H. Huang Kamalan Jeevaratnam Kamalan Jeevaratnam Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed? Frontiers in Cardiovascular Medicine long COVID tachycardia postural orthostatic tachycardia syndrome dysautonomia arrhythmia |
| title | Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed? |
| title_full | Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed? |
| title_fullStr | Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed? |
| title_full_unstemmed | Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed? |
| title_short | Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed? |
| title_sort | long covid 19 and postural orthostatic tachycardia syndrome is dysautonomia to be blamed |
| topic | long COVID tachycardia postural orthostatic tachycardia syndrome dysautonomia arrhythmia |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.860198/full |
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