Immunoglobulin A response to SARS-CoV-2 infection and immunity
The novel coronavirus disease (COVID-19) and its infamous “Variants” of the etiological agent termed Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has proven to be a global health concern. The three antibodies, IgA, IgM, and IgG, perform their dedicated role as main workhorses of the...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024000628 |
| _version_ | 1797336879557771264 |
|---|---|
| author | Khaleqsefat Esmat Baban Jamil Ramiar Kaml Kheder Arnaud John Kombe Kombe Weihong Zeng Huan Ma Tengchuan Jin |
| author_facet | Khaleqsefat Esmat Baban Jamil Ramiar Kaml Kheder Arnaud John Kombe Kombe Weihong Zeng Huan Ma Tengchuan Jin |
| author_sort | Khaleqsefat Esmat |
| collection | DOAJ |
| description | The novel coronavirus disease (COVID-19) and its infamous “Variants” of the etiological agent termed Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has proven to be a global health concern. The three antibodies, IgA, IgM, and IgG, perform their dedicated role as main workhorses of the host adaptive immune system in virus neutralization. Immunoglobulin-A (IgA), also known as “Mucosal Immunoglobulin”, has been under keen interest throughout the viral infection cycle. Its importance lies because IgA is predominant mucosal antibody and SARS family viruses primarily infect the mucosal surfaces of human respiratory tract. Therefore, IgA can be considered a diagnostic and prognostic marker and an active infection biomarker for SARS CoV-2 infection. Along with molecular analyses, serological tests, including IgA detection tests, are gaining ground in application as an early detectable marker and as a minimally invasive detection strategy. In the current review, it was emphasized the role of IgA response in diagnosis, host defense strategies, treatment, and prevention of SARS-CoV-2 infection. The data analysis was performed through almost 100 published peer-reviewed research reports and comprehended the importance of IgA in antiviral immunity against SARS-CoV-2 and other related respiratory viruses. Taken together, it is concluded that secretory IgA- Abs can serve as a promising detection tool for respiratory viral diagnosis and treatment parallel to IgG-based therapeutics and diagnostics. Vaccine candidates that target and trigger mucosal immune response may also be employed in future dimensions of research against other respiratory viruses. |
| first_indexed | 2024-03-08T09:01:19Z |
| format | Article |
| id | doaj.art-28c0f31bfcee4f88ab828a58dfd4b9be |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:01:19Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-28c0f31bfcee4f88ab828a58dfd4b9be2024-02-01T06:34:28ZengElsevierHeliyon2405-84402024-01-01101e24031Immunoglobulin A response to SARS-CoV-2 infection and immunityKhaleqsefat Esmat0Baban Jamil1Ramiar Kaml Kheder2Arnaud John Kombe Kombe3Weihong Zeng4Huan Ma5Tengchuan Jin6Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, ChinaDepartment of Medical Analysis, Faculty of Applied Science, Tishk International University, KRG, Erbil, IraqMedical Laboratory Science Department, College of Science, University of Raparin, Rania, Sulaymaniyah, IraqLaboratory of Structural Immunology, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science & Technology of China, Hefei, Anhui, 230027, ChinaLaboratory of Structural Immunology, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science & Technology of China, Hefei, Anhui, 230027, ChinaLaboratory of Structural Immunology, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science & Technology of China, Hefei, Anhui, 230027, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China; Laboratory of Structural Immunology, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science & Technology of China, Hefei, Anhui, 230027, China; Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, China; Corresponding author. Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.The novel coronavirus disease (COVID-19) and its infamous “Variants” of the etiological agent termed Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has proven to be a global health concern. The three antibodies, IgA, IgM, and IgG, perform their dedicated role as main workhorses of the host adaptive immune system in virus neutralization. Immunoglobulin-A (IgA), also known as “Mucosal Immunoglobulin”, has been under keen interest throughout the viral infection cycle. Its importance lies because IgA is predominant mucosal antibody and SARS family viruses primarily infect the mucosal surfaces of human respiratory tract. Therefore, IgA can be considered a diagnostic and prognostic marker and an active infection biomarker for SARS CoV-2 infection. Along with molecular analyses, serological tests, including IgA detection tests, are gaining ground in application as an early detectable marker and as a minimally invasive detection strategy. In the current review, it was emphasized the role of IgA response in diagnosis, host defense strategies, treatment, and prevention of SARS-CoV-2 infection. The data analysis was performed through almost 100 published peer-reviewed research reports and comprehended the importance of IgA in antiviral immunity against SARS-CoV-2 and other related respiratory viruses. Taken together, it is concluded that secretory IgA- Abs can serve as a promising detection tool for respiratory viral diagnosis and treatment parallel to IgG-based therapeutics and diagnostics. Vaccine candidates that target and trigger mucosal immune response may also be employed in future dimensions of research against other respiratory viruses.http://www.sciencedirect.com/science/article/pii/S2405844024000628SARS-CoV-2COVID-19Immunoglobulin A (IgA)Immune responseSerological testMucosal immunity |
| spellingShingle | Khaleqsefat Esmat Baban Jamil Ramiar Kaml Kheder Arnaud John Kombe Kombe Weihong Zeng Huan Ma Tengchuan Jin Immunoglobulin A response to SARS-CoV-2 infection and immunity Heliyon SARS-CoV-2 COVID-19 Immunoglobulin A (IgA) Immune response Serological test Mucosal immunity |
| title | Immunoglobulin A response to SARS-CoV-2 infection and immunity |
| title_full | Immunoglobulin A response to SARS-CoV-2 infection and immunity |
| title_fullStr | Immunoglobulin A response to SARS-CoV-2 infection and immunity |
| title_full_unstemmed | Immunoglobulin A response to SARS-CoV-2 infection and immunity |
| title_short | Immunoglobulin A response to SARS-CoV-2 infection and immunity |
| title_sort | immunoglobulin a response to sars cov 2 infection and immunity |
| topic | SARS-CoV-2 COVID-19 Immunoglobulin A (IgA) Immune response Serological test Mucosal immunity |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024000628 |
| work_keys_str_mv | AT khaleqsefatesmat immunoglobulinaresponsetosarscov2infectionandimmunity AT babanjamil immunoglobulinaresponsetosarscov2infectionandimmunity AT ramiarkamlkheder immunoglobulinaresponsetosarscov2infectionandimmunity AT arnaudjohnkombekombe immunoglobulinaresponsetosarscov2infectionandimmunity AT weihongzeng immunoglobulinaresponsetosarscov2infectionandimmunity AT huanma immunoglobulinaresponsetosarscov2infectionandimmunity AT tengchuanjin immunoglobulinaresponsetosarscov2infectionandimmunity |