Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies
Meta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these a...
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MDPI AG
2021-01-01
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author | Ivan Kushkevych Kristýna Martínková Monika Vítězová Simon K.-M. R. Rittmann |
author_facet | Ivan Kushkevych Kristýna Martínková Monika Vítězová Simon K.-M. R. Rittmann |
author_sort | Ivan Kushkevych |
collection | DOAJ |
description | Meta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these are targeted with the same research question. It is, therefore, inevitable to have the means to systematically evaluate information and compare research results. Ulcerative colitis together with Crohn’s disease are among the two main inflammatory bowel diseases. This chronic disease of the gastrointestinal tract, with an as yet unclear etiology, is presented by an uncontrolled inflammatory immune response in genetically predisposed individuals to as yet undefined environmental factors in interaction with the intestinal microbiota itself. In patients with ulcerative colitis (UC), changes in the composition and relative abundance of microorganisms could be observed. Sulfate-reducing bacteria (SRB), which commonly occur in the large intestine as part of the commensal microbiota of animals and humans involved in the pathogenesis of the disease, have been shown to occur. SRB are anaerobic organisms affecting short-chain fatty acid metabolism. This work outlines the perspectives of the use of meta-analysis for UC and changes in the representation of intestinal organisms in these patients. |
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issn | 2077-0383 |
language | English |
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spelling | doaj.art-28cac6e0466f41baa6a3c76806f996cf2023-12-03T14:42:45ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110346210.3390/jcm10030462Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis StudiesIvan Kushkevych0Kristýna Martínková1Monika Vítězová2Simon K.-M. R. Rittmann3Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech RepublicDepartment of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech RepublicDepartment of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech RepublicArchaea Physiology and Biotechnology Group, Department of Functional and Evolutionary Ecology, Universität Wien, 1090 Vienna, AustriaMeta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these are targeted with the same research question. It is, therefore, inevitable to have the means to systematically evaluate information and compare research results. Ulcerative colitis together with Crohn’s disease are among the two main inflammatory bowel diseases. This chronic disease of the gastrointestinal tract, with an as yet unclear etiology, is presented by an uncontrolled inflammatory immune response in genetically predisposed individuals to as yet undefined environmental factors in interaction with the intestinal microbiota itself. In patients with ulcerative colitis (UC), changes in the composition and relative abundance of microorganisms could be observed. Sulfate-reducing bacteria (SRB), which commonly occur in the large intestine as part of the commensal microbiota of animals and humans involved in the pathogenesis of the disease, have been shown to occur. SRB are anaerobic organisms affecting short-chain fatty acid metabolism. This work outlines the perspectives of the use of meta-analysis for UC and changes in the representation of intestinal organisms in these patients.https://www.mdpi.com/2077-0383/10/3/462intestinal microbiomesulfate-reducing bacteriahydrogen sulfideinflammatory bowel diseasesulcerative colitismeta-analysis |
spellingShingle | Ivan Kushkevych Kristýna Martínková Monika Vítězová Simon K.-M. R. Rittmann Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies Journal of Clinical Medicine intestinal microbiome sulfate-reducing bacteria hydrogen sulfide inflammatory bowel diseases ulcerative colitis meta-analysis |
title | Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies |
title_full | Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies |
title_fullStr | Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies |
title_full_unstemmed | Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies |
title_short | Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies |
title_sort | intestinal microbiota and perspectives of the use of meta analysis for comparison of ulcerative colitis studies |
topic | intestinal microbiome sulfate-reducing bacteria hydrogen sulfide inflammatory bowel diseases ulcerative colitis meta-analysis |
url | https://www.mdpi.com/2077-0383/10/3/462 |
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