Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies

Meta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these a...

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Main Authors: Ivan Kushkevych, Kristýna Martínková, Monika Vítězová, Simon K.-M. R. Rittmann
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/10/3/462
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author Ivan Kushkevych
Kristýna Martínková
Monika Vítězová
Simon K.-M. R. Rittmann
author_facet Ivan Kushkevych
Kristýna Martínková
Monika Vítězová
Simon K.-M. R. Rittmann
author_sort Ivan Kushkevych
collection DOAJ
description Meta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these are targeted with the same research question. It is, therefore, inevitable to have the means to systematically evaluate information and compare research results. Ulcerative colitis together with Crohn’s disease are among the two main inflammatory bowel diseases. This chronic disease of the gastrointestinal tract, with an as yet unclear etiology, is presented by an uncontrolled inflammatory immune response in genetically predisposed individuals to as yet undefined environmental factors in interaction with the intestinal microbiota itself. In patients with ulcerative colitis (UC), changes in the composition and relative abundance of microorganisms could be observed. Sulfate-reducing bacteria (SRB), which commonly occur in the large intestine as part of the commensal microbiota of animals and humans involved in the pathogenesis of the disease, have been shown to occur. SRB are anaerobic organisms affecting short-chain fatty acid metabolism. This work outlines the perspectives of the use of meta-analysis for UC and changes in the representation of intestinal organisms in these patients.
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spelling doaj.art-28cac6e0466f41baa6a3c76806f996cf2023-12-03T14:42:45ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110346210.3390/jcm10030462Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis StudiesIvan Kushkevych0Kristýna Martínková1Monika Vítězová2Simon K.-M. R. Rittmann3Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech RepublicDepartment of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech RepublicDepartment of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech RepublicArchaea Physiology and Biotechnology Group, Department of Functional and Evolutionary Ecology, Universität Wien, 1090 Vienna, AustriaMeta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these are targeted with the same research question. It is, therefore, inevitable to have the means to systematically evaluate information and compare research results. Ulcerative colitis together with Crohn’s disease are among the two main inflammatory bowel diseases. This chronic disease of the gastrointestinal tract, with an as yet unclear etiology, is presented by an uncontrolled inflammatory immune response in genetically predisposed individuals to as yet undefined environmental factors in interaction with the intestinal microbiota itself. In patients with ulcerative colitis (UC), changes in the composition and relative abundance of microorganisms could be observed. Sulfate-reducing bacteria (SRB), which commonly occur in the large intestine as part of the commensal microbiota of animals and humans involved in the pathogenesis of the disease, have been shown to occur. SRB are anaerobic organisms affecting short-chain fatty acid metabolism. This work outlines the perspectives of the use of meta-analysis for UC and changes in the representation of intestinal organisms in these patients.https://www.mdpi.com/2077-0383/10/3/462intestinal microbiomesulfate-reducing bacteriahydrogen sulfideinflammatory bowel diseasesulcerative colitismeta-analysis
spellingShingle Ivan Kushkevych
Kristýna Martínková
Monika Vítězová
Simon K.-M. R. Rittmann
Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies
Journal of Clinical Medicine
intestinal microbiome
sulfate-reducing bacteria
hydrogen sulfide
inflammatory bowel diseases
ulcerative colitis
meta-analysis
title Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies
title_full Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies
title_fullStr Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies
title_full_unstemmed Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies
title_short Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies
title_sort intestinal microbiota and perspectives of the use of meta analysis for comparison of ulcerative colitis studies
topic intestinal microbiome
sulfate-reducing bacteria
hydrogen sulfide
inflammatory bowel diseases
ulcerative colitis
meta-analysis
url https://www.mdpi.com/2077-0383/10/3/462
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