Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study
We investigate the impact of lung metastasis versus metastasis of bone, brain, or liver on overall survival (OS) and thyroid cancer-specific survival (TCSS) in patients with thyroid cancer (TC). Therefore, de-identified SEER 18 registry data of primary TC patients diagnosed between 2010 and 2016 wer...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/13/3133 |
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| author | Miaochun Zhong Farhana Zerin Khan Xianghong He Lingfei Cui Kefeng Lei Minghua Ge |
| author_facet | Miaochun Zhong Farhana Zerin Khan Xianghong He Lingfei Cui Kefeng Lei Minghua Ge |
| author_sort | Miaochun Zhong |
| collection | DOAJ |
| description | We investigate the impact of lung metastasis versus metastasis of bone, brain, or liver on overall survival (OS) and thyroid cancer-specific survival (TCSS) in patients with thyroid cancer (TC). Therefore, de-identified SEER 18 registry data of primary TC patients diagnosed between 2010 and 2016 were analyzed. The primary outcome was the prognosis of TC patients with lung metastasis compared with other sites. The secondary outcomes included the prognosis comparison between patients with and without surgery and between single and multiple metastasis sites. Isolated lung metastasis was associated with worse OS and TCSS than bone metastasis (both <i>p</i> < 0.05) and was associated with worse OS than liver metastasis (<i>p</i> = 0.0467). Surgery performed either for the primary or distant site was associated with better OS and TCSS in patients with metastasis of lung or bone (<i>p</i> < 0.05). Isolated lung metastasis was related to better OS and TCSS than lung–liver, lung–brain, and lung–other multiple metastases. The multivariable analysis revealed that age < 55 years, surgery to the primary site, and to the distant site(s) were associated with better outcomes, while T4 and Tx were associated with worse outcomes. Nevertheless, it revealed that the other race (i.e., any race other than white, black, or unknown) and male gender were associated with better TCSS only (<i>p</i> < 0.05). Isolated lung metastasis is associated with a worse prognosis in TC patients compared with bone or liver metastasis. Surgery performed either for the primary or distant site(s) is associated with better survival outcomes in TC patients with metastasis of lung or bone. |
| first_indexed | 2024-03-09T22:03:16Z |
| format | Article |
| id | doaj.art-28cad3810ff848f681dd85bee9f63e53 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:03:16Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-28cad3810ff848f681dd85bee9f63e532023-11-23T19:44:59ZengMDPI AGCancers2072-66942022-06-011413313310.3390/cancers14133133Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based StudyMiaochun Zhong0Farhana Zerin Khan1Xianghong He2Lingfei Cui3Kefeng Lei4Minghua Ge5Department of Clinical Medicine, Medical College of Soochow University, Suzhou 215006, ChinaDepartment of Pediatric Surgery, Square Hospital Pvt. Ltd., Dhaka 1205, BangladeshPublic Basic Courses Department, Guangdong University of Science and Technology, Dongguan 523083, ChinaDepartment of General Surgery, The 7th Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, ChinaDepartment of General Surgery, The 7th Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, ChinaDepartment of Clinical Medicine, Medical College of Soochow University, Suzhou 215006, ChinaWe investigate the impact of lung metastasis versus metastasis of bone, brain, or liver on overall survival (OS) and thyroid cancer-specific survival (TCSS) in patients with thyroid cancer (TC). Therefore, de-identified SEER 18 registry data of primary TC patients diagnosed between 2010 and 2016 were analyzed. The primary outcome was the prognosis of TC patients with lung metastasis compared with other sites. The secondary outcomes included the prognosis comparison between patients with and without surgery and between single and multiple metastasis sites. Isolated lung metastasis was associated with worse OS and TCSS than bone metastasis (both <i>p</i> < 0.05) and was associated with worse OS than liver metastasis (<i>p</i> = 0.0467). Surgery performed either for the primary or distant site was associated with better OS and TCSS in patients with metastasis of lung or bone (<i>p</i> < 0.05). Isolated lung metastasis was related to better OS and TCSS than lung–liver, lung–brain, and lung–other multiple metastases. The multivariable analysis revealed that age < 55 years, surgery to the primary site, and to the distant site(s) were associated with better outcomes, while T4 and Tx were associated with worse outcomes. Nevertheless, it revealed that the other race (i.e., any race other than white, black, or unknown) and male gender were associated with better TCSS only (<i>p</i> < 0.05). Isolated lung metastasis is associated with a worse prognosis in TC patients compared with bone or liver metastasis. Surgery performed either for the primary or distant site(s) is associated with better survival outcomes in TC patients with metastasis of lung or bone.https://www.mdpi.com/2072-6694/14/13/3133thyroid cancerlung metastasisthyroid cancer-specific survival (TCSS)overall survival (OS)surgery |
| spellingShingle | Miaochun Zhong Farhana Zerin Khan Xianghong He Lingfei Cui Kefeng Lei Minghua Ge Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study Cancers thyroid cancer lung metastasis thyroid cancer-specific survival (TCSS) overall survival (OS) surgery |
| title | Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study |
| title_full | Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study |
| title_fullStr | Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study |
| title_full_unstemmed | Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study |
| title_short | Impact of Lung Metastasis versus Metastasis of Bone, Brain, or Liver on Overall Survival and Thyroid Cancer-Specific Survival of Thyroid Cancer Patients: A Population-Based Study |
| title_sort | impact of lung metastasis versus metastasis of bone brain or liver on overall survival and thyroid cancer specific survival of thyroid cancer patients a population based study |
| topic | thyroid cancer lung metastasis thyroid cancer-specific survival (TCSS) overall survival (OS) surgery |
| url | https://www.mdpi.com/2072-6694/14/13/3133 |
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