Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study
Alveolo-pleural fistula remains a serious post-operative complication in lung cancer patients after surgery, which is associated with prolonged hospital stay and higher healthcare costs. The aim of this study is to evaluate the efficacy of a polyglycol acid (PGA)-sheet known as Neoveil in preventing...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/7/2719 |
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| author | Carolina Sassorossi Maria Teresa Congedo Dania Nachira Diomira Tabacco Marco Chiappetta Jessica Evangelista Adele di Gioia Velia Di Resta Claudio Sorino Michele Mondoni Fausto Leoncini Giuseppe Calabrese Antonio Giulio Napolitano Adriana Nocera Achille Lococo Stefano Margaritora Filippo Lococo |
| author_facet | Carolina Sassorossi Maria Teresa Congedo Dania Nachira Diomira Tabacco Marco Chiappetta Jessica Evangelista Adele di Gioia Velia Di Resta Claudio Sorino Michele Mondoni Fausto Leoncini Giuseppe Calabrese Antonio Giulio Napolitano Adriana Nocera Achille Lococo Stefano Margaritora Filippo Lococo |
| author_sort | Carolina Sassorossi |
| collection | DOAJ |
| description | Alveolo-pleural fistula remains a serious post-operative complication in lung cancer patients after surgery, which is associated with prolonged hospital stay and higher healthcare costs. The aim of this study is to evaluate the efficacy of a polyglycol acid (PGA)-sheet known as Neoveil in preventing post-operative air-leak in cases of detected intra-operative air-leak after lung resection. Between 11/2021 and 7/2022, a total of 329 non-small cell lung cancer (NSCLC) patients were surgically treated in two institutions. Major lung resections were performed in 251 cases. Among them, 44 patients with significant intra-operative air-leak at surgery were treated by reinforcing staple lines with Neoveil (study group). On the other hand, a historical group (selected by propensity score matched analysis) consisting of 44 lung cancer patients with significant intra-operative air leak treated by methods other than the application of sealant patches were considered as the control group. The presence of prolonged air-leak (primary endpoint), pleural drainage duration, hospital stay, and post-operative complication rates were evaluated. The results showed that prolonged air-leak (>5 days after surgery) was not observed in study group, while this event occurred in four patients (9.1%) in the control group. Additionally, a substantial reduction (despite not statistically significant) in the chest tube removal was noted in the study group with respect to the control group (3.5 vs. 4.5, <i>p</i> = 0.189). In addition, a significant decrease in hospital stay (4 vs. 6 days, <i>p</i> = 0.045) and a reduction in post-operative complications (2 vs. 10, <i>p</i> = 0.015) were observed in the study group when compared with the control group. Therefore, in cases associated with intra-operative air-leak after major lung resection, Neoveil was considered a safer and more effective aerostatic tool and represents a viable option during surgical procedures. |
| first_indexed | 2024-03-11T05:32:33Z |
| format | Article |
| id | doaj.art-28cc11ebc0f6445787069d4870d9bea1 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T05:32:33Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-28cc11ebc0f6445787069d4870d9bea12023-11-17T17:01:00ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01127271910.3390/jcm12072719Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control StudyCarolina Sassorossi0Maria Teresa Congedo1Dania Nachira2Diomira Tabacco3Marco Chiappetta4Jessica Evangelista5Adele di Gioia6Velia Di Resta7Claudio Sorino8Michele Mondoni9Fausto Leoncini10Giuseppe Calabrese11Antonio Giulio Napolitano12Adriana Nocera13Achille Lococo14Stefano Margaritora15Filippo Lococo16Departement of Thoracic Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartement of Thoracic Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyThoracic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartement of Thoracic Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartement of Thoracic Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyThoracic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartment of Thoracic Surgery, “Pierangeli” Hospital, 65124 Pescara, ItalyDepartment of Thoracic Surgery, “Pierangeli” Hospital, 65124 Pescara, ItalyDivision of Pulmonology, Sant’Anna Hospital, 22020 San Fermo della Battaglia, ItalyRespiratory Unit, Department of Health Sciences, ASST Santi Paolo e Carlo, San Paolo Hospital, University of Milan, 22020 Milan, ItalyDepartment of Pulmonology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyThoracic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyThoracic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDepartement of Thoracic Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Thoracic Surgery, “Pierangeli” Hospital, 65124 Pescara, ItalyDepartement of Thoracic Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartement of Thoracic Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyAlveolo-pleural fistula remains a serious post-operative complication in lung cancer patients after surgery, which is associated with prolonged hospital stay and higher healthcare costs. The aim of this study is to evaluate the efficacy of a polyglycol acid (PGA)-sheet known as Neoveil in preventing post-operative air-leak in cases of detected intra-operative air-leak after lung resection. Between 11/2021 and 7/2022, a total of 329 non-small cell lung cancer (NSCLC) patients were surgically treated in two institutions. Major lung resections were performed in 251 cases. Among them, 44 patients with significant intra-operative air-leak at surgery were treated by reinforcing staple lines with Neoveil (study group). On the other hand, a historical group (selected by propensity score matched analysis) consisting of 44 lung cancer patients with significant intra-operative air leak treated by methods other than the application of sealant patches were considered as the control group. The presence of prolonged air-leak (primary endpoint), pleural drainage duration, hospital stay, and post-operative complication rates were evaluated. The results showed that prolonged air-leak (>5 days after surgery) was not observed in study group, while this event occurred in four patients (9.1%) in the control group. Additionally, a substantial reduction (despite not statistically significant) in the chest tube removal was noted in the study group with respect to the control group (3.5 vs. 4.5, <i>p</i> = 0.189). In addition, a significant decrease in hospital stay (4 vs. 6 days, <i>p</i> = 0.045) and a reduction in post-operative complications (2 vs. 10, <i>p</i> = 0.015) were observed in the study group when compared with the control group. Therefore, in cases associated with intra-operative air-leak after major lung resection, Neoveil was considered a safer and more effective aerostatic tool and represents a viable option during surgical procedures.https://www.mdpi.com/2077-0383/12/7/2719NSCLCair-leaklung canceraerostasislung resection |
| spellingShingle | Carolina Sassorossi Maria Teresa Congedo Dania Nachira Diomira Tabacco Marco Chiappetta Jessica Evangelista Adele di Gioia Velia Di Resta Claudio Sorino Michele Mondoni Fausto Leoncini Giuseppe Calabrese Antonio Giulio Napolitano Adriana Nocera Achille Lococo Stefano Margaritora Filippo Lococo Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study Journal of Clinical Medicine NSCLC air-leak lung cancer aerostasis lung resection |
| title | Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study |
| title_full | Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study |
| title_fullStr | Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study |
| title_full_unstemmed | Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study |
| title_short | Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study |
| title_sort | reducing post operative alveolo pleural fistula by applying pga sheets neoveil after major lung resection a historical case control study |
| topic | NSCLC air-leak lung cancer aerostasis lung resection |
| url | https://www.mdpi.com/2077-0383/12/7/2719 |
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