Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis.
<h4>Background</h4>Chinese populations have a higher proportion of intracerebral hemorrhage (ICH) in total strokes. However, the reasons are not fully understood.<h4>Methods</h4>To assess the differences in frequency of major risk factors between ICH and ischemic stroke (IS)...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0151743 |
| _version_ | 1798030239341740032 |
|---|---|
| author | Chung-Fen Tsai Niall Anderson Brenda Thomas Cathie L M Sudlow |
| author_facet | Chung-Fen Tsai Niall Anderson Brenda Thomas Cathie L M Sudlow |
| author_sort | Chung-Fen Tsai |
| collection | DOAJ |
| description | <h4>Background</h4>Chinese populations have a higher proportion of intracerebral hemorrhage (ICH) in total strokes. However, the reasons are not fully understood.<h4>Methods</h4>To assess the differences in frequency of major risk factors between ICH and ischemic stroke (IS) in Chinese versus white populations of European descent, we systematically sought studies conducted since 1990 that compared frequency of risk factors between ICH and IS in Chinese or white populations. For each risk factor, in Chinese and Whites separately, we calculated study-specific and random effects pooled prevalence and odds ratios (ORs) for ICH versus IS.<h4>Results</h4>Six studies among 36,190 Chinese, and seven among 52,100 white stroke patients studied hypertension, diabetes, atrial fibrillation (AF), ischemic heart disease (IHD), hypercholesterolemia, smoking and alcohol. Pooled prevalence of AF was significantly lower in Chinese. Pooled ORs for ICH versus IS were mostly similar in Chinese and Whites. However, in Chinese--but not Whites--mean age was lower (62 versus 69 years), while hypertension and alcohol were significantly more frequent in ICH than IS (ORs 1.38, 95% CI 1.18-1.62, and 1.46, 1.12-1.91). Hypercholesterolemia and smoking were significantly less frequent in ICH in Whites, but not Chinese, while IHD, AF and diabetes were less frequent in ICH in both.<h4>Conclusions</h4>Different risk factor distributions in ICH and IS raise interesting possibilities about variation in mechanisms underlying the different distributions of pathological types of stroke between Chinese and Whites. Further analyses in large, prospective studies, including adjustment for potential confounders, are needed to consolidate and extend these findings. |
| first_indexed | 2024-04-11T19:38:13Z |
| format | Article |
| id | doaj.art-28cc12fc9ec042738a39f45e18587efd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T19:38:13Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-28cc12fc9ec042738a39f45e18587efd2022-12-22T04:06:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015174310.1371/journal.pone.0151743Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis.Chung-Fen TsaiNiall AndersonBrenda ThomasCathie L M Sudlow<h4>Background</h4>Chinese populations have a higher proportion of intracerebral hemorrhage (ICH) in total strokes. However, the reasons are not fully understood.<h4>Methods</h4>To assess the differences in frequency of major risk factors between ICH and ischemic stroke (IS) in Chinese versus white populations of European descent, we systematically sought studies conducted since 1990 that compared frequency of risk factors between ICH and IS in Chinese or white populations. For each risk factor, in Chinese and Whites separately, we calculated study-specific and random effects pooled prevalence and odds ratios (ORs) for ICH versus IS.<h4>Results</h4>Six studies among 36,190 Chinese, and seven among 52,100 white stroke patients studied hypertension, diabetes, atrial fibrillation (AF), ischemic heart disease (IHD), hypercholesterolemia, smoking and alcohol. Pooled prevalence of AF was significantly lower in Chinese. Pooled ORs for ICH versus IS were mostly similar in Chinese and Whites. However, in Chinese--but not Whites--mean age was lower (62 versus 69 years), while hypertension and alcohol were significantly more frequent in ICH than IS (ORs 1.38, 95% CI 1.18-1.62, and 1.46, 1.12-1.91). Hypercholesterolemia and smoking were significantly less frequent in ICH in Whites, but not Chinese, while IHD, AF and diabetes were less frequent in ICH in both.<h4>Conclusions</h4>Different risk factor distributions in ICH and IS raise interesting possibilities about variation in mechanisms underlying the different distributions of pathological types of stroke between Chinese and Whites. Further analyses in large, prospective studies, including adjustment for potential confounders, are needed to consolidate and extend these findings.https://doi.org/10.1371/journal.pone.0151743 |
| spellingShingle | Chung-Fen Tsai Niall Anderson Brenda Thomas Cathie L M Sudlow Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis. PLoS ONE |
| title | Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis. |
| title_full | Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis. |
| title_fullStr | Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis. |
| title_full_unstemmed | Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis. |
| title_short | Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis. |
| title_sort | comparing risk factor profiles between intracerebral hemorrhage and ischemic stroke in chinese and white populations systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0151743 |
| work_keys_str_mv | AT chungfentsai comparingriskfactorprofilesbetweenintracerebralhemorrhageandischemicstrokeinchineseandwhitepopulationssystematicreviewandmetaanalysis AT niallanderson comparingriskfactorprofilesbetweenintracerebralhemorrhageandischemicstrokeinchineseandwhitepopulationssystematicreviewandmetaanalysis AT brendathomas comparingriskfactorprofilesbetweenintracerebralhemorrhageandischemicstrokeinchineseandwhitepopulationssystematicreviewandmetaanalysis AT cathielmsudlow comparingriskfactorprofilesbetweenintracerebralhemorrhageandischemicstrokeinchineseandwhitepopulationssystematicreviewandmetaanalysis |