Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature
Hugo Hyung Bok Yoo,1 Flávia Luiza Marin2 1Department of Pulmonology, Botucatu Medical School of São Paulo State University (UNESP), Botucatu, São Paulo, Brazil; 2Department of Internal Medicine, State University of Western Paraná (UNIOESTE), Francisco Beltrão, Paraná, BrazilCorrespondence: Hugo Hyun...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-02-01
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| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/treating-inflammation-associated-with-pulmonary-hypertension-an-overvi-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1798024123578843136 |
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| author | Yoo HHB Marin FL |
| author_facet | Yoo HHB Marin FL |
| author_sort | Yoo HHB |
| collection | DOAJ |
| description | Hugo Hyung Bok Yoo,1 Flávia Luiza Marin2 1Department of Pulmonology, Botucatu Medical School of São Paulo State University (UNESP), Botucatu, São Paulo, Brazil; 2Department of Internal Medicine, State University of Western Paraná (UNIOESTE), Francisco Beltrão, Paraná, BrazilCorrespondence: Hugo Hyung Bok Yoo, Email hugo.yoo@unesp.brAbstract: Pulmonary hypertension (PH) comprises five groups of serious clinical entities characterized by pulmonary artery vasoconstriction and vascular remodeling leading to right heart failure and death. In addition to vascular remodeling, recruitment and exaggerated accumulation of several perivascular inflammatory cells is also observed, including macrophages, monocytes, T and B-lymphocytes, dendritic cells and mast cells distributed in pulmonary perivascular spaces and around remodeling pulmonary vessels. Current pulmonary arterial hypertension (PAH)-targeted therapies aim to improve functional capacity, pulmonary hemodynamic conditions, and delay disease progression. Nevertheless, PAH remains incurable, with a poor prognosis and is often refractory to drug therapy, highlighting the need for further research. In the last three decades, the best pathophysiological understanding of PAH has allowed for progression from a disease of little-known pathogenesis, without specific and effective therapy to expanding the arsenal of drugs on a cellular, genetic and molecular basis. This article provides an overview on current knowledge and progress in recent advances in pharmacological therapy in PAH.Keywords: pulmonary arterial hypertension, inflammation, treatment |
| first_indexed | 2024-04-11T17:57:20Z |
| format | Article |
| id | doaj.art-28ccdacb19224d0a9076074208ecaec9 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-11T17:57:20Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-28ccdacb19224d0a9076074208ecaec92022-12-22T04:10:37ZengDove Medical PressInternational Journal of General Medicine1178-70742022-02-01Volume 151075108372676Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the LiteratureYoo HHBMarin FLHugo Hyung Bok Yoo,1 Flávia Luiza Marin2 1Department of Pulmonology, Botucatu Medical School of São Paulo State University (UNESP), Botucatu, São Paulo, Brazil; 2Department of Internal Medicine, State University of Western Paraná (UNIOESTE), Francisco Beltrão, Paraná, BrazilCorrespondence: Hugo Hyung Bok Yoo, Email hugo.yoo@unesp.brAbstract: Pulmonary hypertension (PH) comprises five groups of serious clinical entities characterized by pulmonary artery vasoconstriction and vascular remodeling leading to right heart failure and death. In addition to vascular remodeling, recruitment and exaggerated accumulation of several perivascular inflammatory cells is also observed, including macrophages, monocytes, T and B-lymphocytes, dendritic cells and mast cells distributed in pulmonary perivascular spaces and around remodeling pulmonary vessels. Current pulmonary arterial hypertension (PAH)-targeted therapies aim to improve functional capacity, pulmonary hemodynamic conditions, and delay disease progression. Nevertheless, PAH remains incurable, with a poor prognosis and is often refractory to drug therapy, highlighting the need for further research. In the last three decades, the best pathophysiological understanding of PAH has allowed for progression from a disease of little-known pathogenesis, without specific and effective therapy to expanding the arsenal of drugs on a cellular, genetic and molecular basis. This article provides an overview on current knowledge and progress in recent advances in pharmacological therapy in PAH.Keywords: pulmonary arterial hypertension, inflammation, treatmenthttps://www.dovepress.com/treating-inflammation-associated-with-pulmonary-hypertension-an-overvi-peer-reviewed-fulltext-article-IJGMpulmonary arterial hypertensioninflammationtreatment |
| spellingShingle | Yoo HHB Marin FL Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature International Journal of General Medicine pulmonary arterial hypertension inflammation treatment |
| title | Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature |
| title_full | Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature |
| title_fullStr | Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature |
| title_full_unstemmed | Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature |
| title_short | Treating Inflammation Associated with Pulmonary Hypertension: An Overview of the Literature |
| title_sort | treating inflammation associated with pulmonary hypertension an overview of the literature |
| topic | pulmonary arterial hypertension inflammation treatment |
| url | https://www.dovepress.com/treating-inflammation-associated-with-pulmonary-hypertension-an-overvi-peer-reviewed-fulltext-article-IJGM |
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