Support of Tumor Endothelial Cells by Chemokine Receptors
Tumor-associated vascular endothelium comprises a specialized and diverse group of endothelial cells that, although not cancer themselves, are integral to cancer progression. Targeting the tumor vasculature can have significant efficacy in reducing tumor burden, although loss of efficacy due to acqu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00147/full |
| _version_ | 1819091889126637568 |
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| author | Nicole Salazar Brian A. Zabel |
| author_facet | Nicole Salazar Brian A. Zabel |
| author_sort | Nicole Salazar |
| collection | DOAJ |
| description | Tumor-associated vascular endothelium comprises a specialized and diverse group of endothelial cells that, although not cancer themselves, are integral to cancer progression. Targeting the tumor vasculature can have significant efficacy in reducing tumor burden, although loss of efficacy due to acquisition of resistance mechanisms is common. Here we review mechanisms by which tumor endothelial cells (TEC) utilize chemokine receptors to support tumor progression. We illustrate how chemokine receptors support and may serve as functional markers of the diverse TEC population. We focus on ACKR1 (DARC), ACKR3 (CXCR7), CXCR4, and CCR2, as these are the best studied chemokine receptors in TEC; and suggest that targeting these receptors on the tumor vasculature may prove efficacious in slowing or reversing tumor growth. We also mention CXCR2 and CXCR3 as important mediators or tumor angiogenesis, given their distinct roles with angiogenic and angiostatic chemokines, respectively. |
| first_indexed | 2024-12-21T22:46:53Z |
| format | Article |
| id | doaj.art-28cdb9a5484942ccbc77712235066ab9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T22:46:53Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-28cdb9a5484942ccbc77712235066ab92022-12-21T18:47:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-02-011010.3389/fimmu.2019.00147436617Support of Tumor Endothelial Cells by Chemokine ReceptorsNicole Salazar0Brian A. Zabel1Department of Biology, San Francisco State University, San Francisco, CA, United StatesPalo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United StatesTumor-associated vascular endothelium comprises a specialized and diverse group of endothelial cells that, although not cancer themselves, are integral to cancer progression. Targeting the tumor vasculature can have significant efficacy in reducing tumor burden, although loss of efficacy due to acquisition of resistance mechanisms is common. Here we review mechanisms by which tumor endothelial cells (TEC) utilize chemokine receptors to support tumor progression. We illustrate how chemokine receptors support and may serve as functional markers of the diverse TEC population. We focus on ACKR1 (DARC), ACKR3 (CXCR7), CXCR4, and CCR2, as these are the best studied chemokine receptors in TEC; and suggest that targeting these receptors on the tumor vasculature may prove efficacious in slowing or reversing tumor growth. We also mention CXCR2 and CXCR3 as important mediators or tumor angiogenesis, given their distinct roles with angiogenic and angiostatic chemokines, respectively.https://www.frontiersin.org/article/10.3389/fimmu.2019.00147/fullchemokine receptorchemoattractantendothelial celltumor vasculaturetumor microenvironment |
| spellingShingle | Nicole Salazar Brian A. Zabel Support of Tumor Endothelial Cells by Chemokine Receptors Frontiers in Immunology chemokine receptor chemoattractant endothelial cell tumor vasculature tumor microenvironment |
| title | Support of Tumor Endothelial Cells by Chemokine Receptors |
| title_full | Support of Tumor Endothelial Cells by Chemokine Receptors |
| title_fullStr | Support of Tumor Endothelial Cells by Chemokine Receptors |
| title_full_unstemmed | Support of Tumor Endothelial Cells by Chemokine Receptors |
| title_short | Support of Tumor Endothelial Cells by Chemokine Receptors |
| title_sort | support of tumor endothelial cells by chemokine receptors |
| topic | chemokine receptor chemoattractant endothelial cell tumor vasculature tumor microenvironment |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00147/full |
| work_keys_str_mv | AT nicolesalazar supportoftumorendothelialcellsbychemokinereceptors AT brianazabel supportoftumorendothelialcellsbychemokinereceptors |