The research progress on the role of FMRP in the pathogenesis of tumors
Fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions. Patients with fragile X syndrome display FMRP deficiency and a lower risk of cancers. However, th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2023-10-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.013 |
| _version_ | 1797374004783218688 |
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| author | Huizhi YANG Sirui LI Guiyue CAI Jingwen ZOU Junnan REN Rongyi CHEN |
| author_facet | Huizhi YANG Sirui LI Guiyue CAI Jingwen ZOU Junnan REN Rongyi CHEN |
| author_sort | Huizhi YANG |
| collection | DOAJ |
| description | Fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions. Patients with fragile X syndrome display FMRP deficiency and a lower risk of cancers. However, the specific function of FMRP and the underlying mechanisms are not clear. Evidence indicates the involvements of FMRP in multiple processes of malignant development, including tumor cell migration, invasion, apoptosis, proliferation and metastasis. In addition, FMRP is associated with the occurrence, development and prognosis of tumors. In this paper, we review the progress on the role of FMRP in the pathogenesis of tumors, exploring more potential biomarkers of tumors and new therapeutic targets. |
| first_indexed | 2024-03-08T18:59:37Z |
| format | Article |
| id | doaj.art-28ce5d97248b4fc9b7aa12fd43dc5173 |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-03-08T18:59:37Z |
| publishDate | 2023-10-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-28ce5d97248b4fc9b7aa12fd43dc51732023-12-28T06:54:48Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682023-10-0130546046410.3969/j.issn.1674-8468.2023.05.013The research progress on the role of FMRP in the pathogenesis of tumorsHuizhi YANG0Sirui LI1Guiyue CAI2Jingwen ZOU3Junnan REN4Rongyi CHEN5Dermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaFragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions. Patients with fragile X syndrome display FMRP deficiency and a lower risk of cancers. However, the specific function of FMRP and the underlying mechanisms are not clear. Evidence indicates the involvements of FMRP in multiple processes of malignant development, including tumor cell migration, invasion, apoptosis, proliferation and metastasis. In addition, FMRP is associated with the occurrence, development and prognosis of tumors. In this paper, we review the progress on the role of FMRP in the pathogenesis of tumors, exploring more potential biomarkers of tumors and new therapeutic targets.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.013fragile x mental retardation proteintumorpathogenesisbiomarker |
| spellingShingle | Huizhi YANG Sirui LI Guiyue CAI Jingwen ZOU Junnan REN Rongyi CHEN The research progress on the role of FMRP in the pathogenesis of tumors Pifu-xingbing zhenliaoxue zazhi fragile x mental retardation protein tumor pathogenesis biomarker |
| title | The research progress on the role of FMRP in the pathogenesis of tumors |
| title_full | The research progress on the role of FMRP in the pathogenesis of tumors |
| title_fullStr | The research progress on the role of FMRP in the pathogenesis of tumors |
| title_full_unstemmed | The research progress on the role of FMRP in the pathogenesis of tumors |
| title_short | The research progress on the role of FMRP in the pathogenesis of tumors |
| title_sort | research progress on the role of fmrp in the pathogenesis of tumors |
| topic | fragile x mental retardation protein tumor pathogenesis biomarker |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.013 |
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