Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis
Introduction: Breast cancer is the most commonly diagnosed cancer worldwide, and most patients experience fatigue. However, there are no effective treatments for cancer-related fatigue (CRF). Several randomized controlled trials (RCTs) have suggested that moxibustion improves CRF. We conducted a sys...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-02-01
|
| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354241233226 |
| _version_ | 1797302261238464512 |
|---|---|
| author | Hye-Ri Bae KMD, MS Eun-Ji Kim KMD, MS Yo-Chan Ahn PhD Jung-Hyo Cho KMD, PhD Chang-Gue Son KMD, PhD Nam-Hun Lee KMD, PhD |
| author_facet | Hye-Ri Bae KMD, MS Eun-Ji Kim KMD, MS Yo-Chan Ahn PhD Jung-Hyo Cho KMD, PhD Chang-Gue Son KMD, PhD Nam-Hun Lee KMD, PhD |
| author_sort | Hye-Ri Bae KMD, MS |
| collection | DOAJ |
| description | Introduction: Breast cancer is the most commonly diagnosed cancer worldwide, and most patients experience fatigue. However, there are no effective treatments for cancer-related fatigue (CRF). Several randomized controlled trials (RCTs) have suggested that moxibustion improves CRF. We conducted a systematic review and meta-analysis to compare the differences in fatigue scale scores, quality of life, and clinical efficacy in patients with breast cancer who developed CRF and did versus did not receive moxibustion. Methods: RCTs were searched in 7 databases using a standardized search method from database inception to March 2023, and RCTs that met the inclusion criteria were selected. Results: Among 1337 initially identified RCTs, 10 RCTs involving 744 participants were selected for this study. The meta-analysis involved assessment of the revised Piper Fatigue Scale scores, Cancer Fatigue Scale scores, Karnofsky Performance Scale scores, Athens Insomnia Scale scores, clinical efficacy, and Qi deficiency syndrome scale scores. Compared with the control, moxibustion was associated with significantly better Piper Fatigue Scale scores ( P < 0.0001), quality of life [Karnofsky Performance Scale scores ( P < 0.0001)], clinical efficacy ( P = 0.0007), and Qi deficiency syndrome scale scores ( P = 0.02). Conclusions: Moxibustion improves CRF in patients with breast cancer. The efficacy of moxibustion should be further examined by high-quality studies in various countries with patients subdivided by their breast cancer treatment status. Registration: PROSPERO ID: CRD42023451292 |
| first_indexed | 2024-03-07T23:34:15Z |
| format | Article |
| id | doaj.art-28cf0fcaf4ac497e9a1a6c71c7385cd2 |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-03-07T23:34:15Z |
| publishDate | 2024-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-28cf0fcaf4ac497e9a1a6c71c7385cd22024-02-20T09:03:22ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2024-02-012310.1177/15347354241233226Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-AnalysisHye-Ri Bae KMD, MS0Eun-Ji Kim KMD, MS1Yo-Chan Ahn PhD2Jung-Hyo Cho KMD, PhD3Chang-Gue Son KMD, PhD4Nam-Hun Lee KMD, PhD5East-West Cancer Center, Cheonan Korean Medical Hospital, Daejeon University, Cheonan, Republic of KoreaEast-West Cancer Center, Cheonan Korean Medical Hospital, Daejeon University, Cheonan, Republic of KoreaDepartment of Health Service Management, Daejeon University, Daejeon, Republic of KoreaEast-West Cancer Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of KoreaEast-West Cancer Center, Daejeon Korean Medicine Hospital of Daejeon University, Daejeon, Republic of KoreaEast-West Cancer Center, Cheonan Korean Medical Hospital, Daejeon University, Cheonan, Republic of KoreaIntroduction: Breast cancer is the most commonly diagnosed cancer worldwide, and most patients experience fatigue. However, there are no effective treatments for cancer-related fatigue (CRF). Several randomized controlled trials (RCTs) have suggested that moxibustion improves CRF. We conducted a systematic review and meta-analysis to compare the differences in fatigue scale scores, quality of life, and clinical efficacy in patients with breast cancer who developed CRF and did versus did not receive moxibustion. Methods: RCTs were searched in 7 databases using a standardized search method from database inception to March 2023, and RCTs that met the inclusion criteria were selected. Results: Among 1337 initially identified RCTs, 10 RCTs involving 744 participants were selected for this study. The meta-analysis involved assessment of the revised Piper Fatigue Scale scores, Cancer Fatigue Scale scores, Karnofsky Performance Scale scores, Athens Insomnia Scale scores, clinical efficacy, and Qi deficiency syndrome scale scores. Compared with the control, moxibustion was associated with significantly better Piper Fatigue Scale scores ( P < 0.0001), quality of life [Karnofsky Performance Scale scores ( P < 0.0001)], clinical efficacy ( P = 0.0007), and Qi deficiency syndrome scale scores ( P = 0.02). Conclusions: Moxibustion improves CRF in patients with breast cancer. The efficacy of moxibustion should be further examined by high-quality studies in various countries with patients subdivided by their breast cancer treatment status. Registration: PROSPERO ID: CRD42023451292https://doi.org/10.1177/15347354241233226 |
| spellingShingle | Hye-Ri Bae KMD, MS Eun-Ji Kim KMD, MS Yo-Chan Ahn PhD Jung-Hyo Cho KMD, PhD Chang-Gue Son KMD, PhD Nam-Hun Lee KMD, PhD Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis Integrative Cancer Therapies |
| title | Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis |
| title_full | Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis |
| title_fullStr | Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis |
| title_short | Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis |
| title_sort | efficacy of moxibustion for cancer related fatigue in patients with breast cancer a systematic review and meta analysis |
| url | https://doi.org/10.1177/15347354241233226 |
| work_keys_str_mv | AT hyeribaekmdms efficacyofmoxibustionforcancerrelatedfatigueinpatientswithbreastcancerasystematicreviewandmetaanalysis AT eunjikimkmdms efficacyofmoxibustionforcancerrelatedfatigueinpatientswithbreastcancerasystematicreviewandmetaanalysis AT yochanahnphd efficacyofmoxibustionforcancerrelatedfatigueinpatientswithbreastcancerasystematicreviewandmetaanalysis AT junghyochokmdphd efficacyofmoxibustionforcancerrelatedfatigueinpatientswithbreastcancerasystematicreviewandmetaanalysis AT changguesonkmdphd efficacyofmoxibustionforcancerrelatedfatigueinpatientswithbreastcancerasystematicreviewandmetaanalysis AT namhunleekmdphd efficacyofmoxibustionforcancerrelatedfatigueinpatientswithbreastcancerasystematicreviewandmetaanalysis |