USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the <i>Drosophila</i> Brain and in Human Neurons

USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the <i>Drosophila</i> Brain and in Human Neurons

Stress-induced mitophagy, a tightly regulated process that targets dysfunctional mitochondria for autophagy-dependent degradation, mainly relies on two proteins, PINK1 and Parkin, which genes are mutated in some forms of familiar Parkinson’s Disease (PD). Upon mitochondrial damage, the protein kinas...

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Bibliographic Details
Main Authors: Sofia Mauri, Greta Bernardo, Aitor Martinez, Mariavittoria Favaro, Marta Trevisan, Gael Cobraiville, Marianne Fillet, Federico Caicci, Alexander J. Whitworth, Elena Ziviani
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
autophagy
mitophagy
Parkin
DUBs
USP8
Online Access:https://www.mdpi.com/2073-4409/12/8/1143

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