Evaluation of Serum Fasting Insulin Concentration in Non-diabetic Patients with and without Coronary Artery Disease
Background: Previous studies have been demonstrated the effect of fasting insulin concentration in coronary artery disease of patients with diabetes mellitus. Because of discrepancy in recent studies about this association in non-diabetic patients, we evaluated this effect. Methods: In this cross-s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2019-05-01
|
| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/11369 |
| _version_ | 1797720958135435264 |
|---|---|
| author | Ali Soleimany Reza Hajizadeh Kamal Khademvatani Amir Hajizadeh Esmaeil Abasi |
| author_facet | Ali Soleimany Reza Hajizadeh Kamal Khademvatani Amir Hajizadeh Esmaeil Abasi |
| author_sort | Ali Soleimany |
| collection | DOAJ |
| description | Background: Previous studies have been demonstrated the effect of fasting insulin concentration in coronary artery disease of patients with diabetes mellitus. Because of discrepancy in recent studies about this association in non-diabetic patients, we evaluated this effect.
Methods: In this cross-sectional study, coronary artery angiography was done for 110 non-diabetic patients, and they were divided into two groups of normal coronary artery as control group and those with coronary artery stenosis as case group. Serum levels of glucose, cholesterol, triglycerides, low-density lipoprotein (LDL), and insulin were evaluated after 12 hours fasting period. One-way ANOVA and t tests were used for statistical analysis.
Findings: Fasting blood sugar (FBS) in non-diabetic patients with and without coronary artery disease was 94.4 ± 14.9 and 90.52 ± 13.82 mg/dl, respectively (P = 0.150). The mean insulin concentration was 12.77 ± 3.29 mIU/l in case and 7.01 ± 3.25 mIU/l in control group (P = 0.001). We did not find any difference between men and women according to their fasting insulin concentration (P = 0.210).
Conclusion: Higher serum level of fasting insulin seems to have correlation with coronary artery disease in non-diabetic patients; but further studies with larger population study are needed for better evaluation. |
| first_indexed | 2024-03-12T09:28:01Z |
| format | Article |
| id | doaj.art-28d03a2c917c4d3abf19a9c2ec87af25 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:28:01Z |
| publishDate | 2019-05-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-28d03a2c917c4d3abf19a9c2ec87af252023-09-02T14:05:42ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2019-05-013751819820410.22122/jims.v37i518.113693370Evaluation of Serum Fasting Insulin Concentration in Non-diabetic Patients with and without Coronary Artery DiseaseAli Soleimany0Reza Hajizadeh1Kamal Khademvatani2Amir Hajizadeh3Esmaeil Abasi4Assistant Professor, Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, IranAssistant Professor, Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, IranProfessor, Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, IranStudent of Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, IranDepartment of Parasitology and Mycology, School of Medicine, Urmia University of Medical Sciences, Urmia, IranBackground: Previous studies have been demonstrated the effect of fasting insulin concentration in coronary artery disease of patients with diabetes mellitus. Because of discrepancy in recent studies about this association in non-diabetic patients, we evaluated this effect. Methods: In this cross-sectional study, coronary artery angiography was done for 110 non-diabetic patients, and they were divided into two groups of normal coronary artery as control group and those with coronary artery stenosis as case group. Serum levels of glucose, cholesterol, triglycerides, low-density lipoprotein (LDL), and insulin were evaluated after 12 hours fasting period. One-way ANOVA and t tests were used for statistical analysis. Findings: Fasting blood sugar (FBS) in non-diabetic patients with and without coronary artery disease was 94.4 ± 14.9 and 90.52 ± 13.82 mg/dl, respectively (P = 0.150). The mean insulin concentration was 12.77 ± 3.29 mIU/l in case and 7.01 ± 3.25 mIU/l in control group (P = 0.001). We did not find any difference between men and women according to their fasting insulin concentration (P = 0.210). Conclusion: Higher serum level of fasting insulin seems to have correlation with coronary artery disease in non-diabetic patients; but further studies with larger population study are needed for better evaluation.http://jims.mui.ac.ir/index.php/jims/article/view/11369AtherosclerosisCoronary artery diseaseBlood sugarInsulinCoronary angiography |
| spellingShingle | Ali Soleimany Reza Hajizadeh Kamal Khademvatani Amir Hajizadeh Esmaeil Abasi Evaluation of Serum Fasting Insulin Concentration in Non-diabetic Patients with and without Coronary Artery Disease مجله دانشکده پزشکی اصفهان Atherosclerosis Coronary artery disease Blood sugar Insulin Coronary angiography |
| title | Evaluation of Serum Fasting Insulin Concentration in Non-diabetic Patients with and without Coronary Artery Disease |
| title_full | Evaluation of Serum Fasting Insulin Concentration in Non-diabetic Patients with and without Coronary Artery Disease |
| title_fullStr | Evaluation of Serum Fasting Insulin Concentration in Non-diabetic Patients with and without Coronary Artery Disease |
| title_full_unstemmed | Evaluation of Serum Fasting Insulin Concentration in Non-diabetic Patients with and without Coronary Artery Disease |
| title_short | Evaluation of Serum Fasting Insulin Concentration in Non-diabetic Patients with and without Coronary Artery Disease |
| title_sort | evaluation of serum fasting insulin concentration in non diabetic patients with and without coronary artery disease |
| topic | Atherosclerosis Coronary artery disease Blood sugar Insulin Coronary angiography |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/11369 |
| work_keys_str_mv | AT alisoleimany evaluationofserumfastinginsulinconcentrationinnondiabeticpatientswithandwithoutcoronaryarterydisease AT rezahajizadeh evaluationofserumfastinginsulinconcentrationinnondiabeticpatientswithandwithoutcoronaryarterydisease AT kamalkhademvatani evaluationofserumfastinginsulinconcentrationinnondiabeticpatientswithandwithoutcoronaryarterydisease AT amirhajizadeh evaluationofserumfastinginsulinconcentrationinnondiabeticpatientswithandwithoutcoronaryarterydisease AT esmaeilabasi evaluationofserumfastinginsulinconcentrationinnondiabeticpatientswithandwithoutcoronaryarterydisease |