The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History
With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/5/1/14 |
| _version_ | 1798038828897796096 |
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| author | Harry P. De Koning |
| author_facet | Harry P. De Koning |
| author_sort | Harry P. De Koning |
| collection | DOAJ |
| description | With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and the resistance that the parasites developed against them. This retrospective looks back on the remarkable story of chemotherapy against trypanosomiasis, a story that goes back to the very origins and conception of chemotherapy in the first years of the 20 century and is still not finished today. |
| first_indexed | 2024-04-11T21:45:42Z |
| format | Article |
| id | doaj.art-28d048b7d2904483aa2da4c35742977b |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-04-11T21:45:42Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-28d048b7d2904483aa2da4c35742977b2022-12-22T04:01:25ZengMDPI AGTropical Medicine and Infectious Disease2414-63662020-01-01511410.3390/tropicalmed5010014tropicalmed5010014The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief HistoryHarry P. De Koning0Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UKWith the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that ‘got the job done’: their development, their limitations and the resistance that the parasites developed against them. This retrospective looks back on the remarkable story of chemotherapy against trypanosomiasis, a story that goes back to the very origins and conception of chemotherapy in the first years of the 20 century and is still not finished today.https://www.mdpi.com/2414-6366/5/1/14sleeping sicknesshuman african trypanosomiasistrypanosoma bruceidrugsdrug resistancehistory |
| spellingShingle | Harry P. De Koning The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History Tropical Medicine and Infectious Disease sleeping sickness human african trypanosomiasis trypanosoma brucei drugs drug resistance history |
| title | The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History |
| title_full | The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History |
| title_fullStr | The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History |
| title_full_unstemmed | The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History |
| title_short | The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History |
| title_sort | drugs of sleeping sickness their mechanisms of action and resistance and a brief history |
| topic | sleeping sickness human african trypanosomiasis trypanosoma brucei drugs drug resistance history |
| url | https://www.mdpi.com/2414-6366/5/1/14 |
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