Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcoma
Abstract Background The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who are severely immunosuppressed or have incomplete virologic suppression....
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-018-5019-9 |
| _version_ | 1828773074876497920 |
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| author | Seong Eun Kim Younggon Jung Tae Hoon Oh Uh Jin Kim Seung-Ji Kang Hee-Chang Jang Kyung-Hwa Park Kyung-Hwa Lee Sook In Jung |
| author_facet | Seong Eun Kim Younggon Jung Tae Hoon Oh Uh Jin Kim Seung-Ji Kang Hee-Chang Jang Kyung-Hwa Park Kyung-Hwa Lee Sook In Jung |
| author_sort | Seong Eun Kim |
| collection | DOAJ |
| description | Abstract Background The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who are severely immunosuppressed or have incomplete virologic suppression. Case presentation We report a case of dual primary ADCs, especially NHL followed by KS, in a 70-year-old HIV-infected man who was on antiretroviral therapy and had successful virologic suppression. During HAART, he presented with generalized myalgia and abdominal pain. Multiple liver masses were detected and a biopsy revealed Burkitt’s lymphoma. After three cycles of anticancer chemotherapy with a favorable response, he was diagnosed with cytomegalovirus retinitis and the anti-cancer chemotherapy was discontinued. Despite successful virologic suppression with HAART, human herpes virus-8 associated Kaposi’s sarcoma was diagnosed in his right thigh. He underwent radiation therapy. Conclusion These findings suggest that multiple ADCs can occur in PWHA who are receiving HAART and have successful virologic suppression. Healthcare providers caring for PWHA should maintain vigilance for the development of a broad spectrum of cancers. |
| first_indexed | 2024-12-11T14:56:32Z |
| format | Article |
| id | doaj.art-28d14958dfe846fc8e298c2d4f35ecbb |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T14:56:32Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-28d14958dfe846fc8e298c2d4f35ecbb2022-12-22T01:01:18ZengBMCBMC Cancer1471-24072018-11-011811610.1186/s12885-018-5019-9Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcomaSeong Eun Kim0Younggon Jung1Tae Hoon Oh2Uh Jin Kim3Seung-Ji Kang4Hee-Chang Jang5Kyung-Hwa Park6Kyung-Hwa Lee7Sook In Jung8Department of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolDepartment of Pathology, Chonnam National University Medical SchoolDepartment of Infectious Diseases, Chonnam National University Medical SchoolAbstract Background The incidence of AIDS-defining cancers (ADCs) has decreased markedly in the era of highly active antiretroviral therapy (HAART). The occurrence of two ADCs is rare in people living with HIV or AIDS (PWHA) who are severely immunosuppressed or have incomplete virologic suppression. Case presentation We report a case of dual primary ADCs, especially NHL followed by KS, in a 70-year-old HIV-infected man who was on antiretroviral therapy and had successful virologic suppression. During HAART, he presented with generalized myalgia and abdominal pain. Multiple liver masses were detected and a biopsy revealed Burkitt’s lymphoma. After three cycles of anticancer chemotherapy with a favorable response, he was diagnosed with cytomegalovirus retinitis and the anti-cancer chemotherapy was discontinued. Despite successful virologic suppression with HAART, human herpes virus-8 associated Kaposi’s sarcoma was diagnosed in his right thigh. He underwent radiation therapy. Conclusion These findings suggest that multiple ADCs can occur in PWHA who are receiving HAART and have successful virologic suppression. Healthcare providers caring for PWHA should maintain vigilance for the development of a broad spectrum of cancers.http://link.springer.com/article/10.1186/s12885-018-5019-9HIVBurkitt’s lymphomaKaposi’s sarcomaAntiretroviral therapy |
| spellingShingle | Seong Eun Kim Younggon Jung Tae Hoon Oh Uh Jin Kim Seung-Ji Kang Hee-Chang Jang Kyung-Hwa Park Kyung-Hwa Lee Sook In Jung Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcoma BMC Cancer HIV Burkitt’s lymphoma Kaposi’s sarcoma Antiretroviral therapy |
| title | Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcoma |
| title_full | Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcoma |
| title_fullStr | Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcoma |
| title_full_unstemmed | Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcoma |
| title_short | Case report: dual primary AIDS-defining cancers in an HIV-infected patient receiving antiretroviral therapy: Burkitt’s lymphoma and Kaposi’s sarcoma |
| title_sort | case report dual primary aids defining cancers in an hiv infected patient receiving antiretroviral therapy burkitt s lymphoma and kaposi s sarcoma |
| topic | HIV Burkitt’s lymphoma Kaposi’s sarcoma Antiretroviral therapy |
| url | http://link.springer.com/article/10.1186/s12885-018-5019-9 |
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