Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies
Circadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h rhythms in the body. Many metabolic, cellular, behavioral and physiological processes are regulated by the circadian clock in coordination with environmental cues. The present study is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/3/370 |
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| author | Maria Mentzelou Sousana K. Papadopoulou Dimitrios Papandreou Maria Spanoudaki Antonios Dakanalis Georgios K. Vasios Gavriela Voulgaridou Eleni Pavlidou Maria Mantzorou Constantinos Giaginis |
| author_facet | Maria Mentzelou Sousana K. Papadopoulou Dimitrios Papandreou Maria Spanoudaki Antonios Dakanalis Georgios K. Vasios Gavriela Voulgaridou Eleni Pavlidou Maria Mantzorou Constantinos Giaginis |
| author_sort | Maria Mentzelou |
| collection | DOAJ |
| description | Circadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h rhythms in the body. Many metabolic, cellular, behavioral and physiological processes are regulated by the circadian clock in coordination with environmental cues. The present study is a comprehensive review of the currently existing evidence concerning the relationship between circadian rhythms and sleep, metabolic, and cardiovascular disorders. We thoroughly searched the online databases PubMed, Scopus, and Web of Science to find the existing clinical studies from the last twenty-three years (2000–2023). Circadian misalignment was found to be associated with an increase in the risk of metabolic disorders, cardiovascular diseases, and obesity, as well as inadequate sleep quality. In this review article, all the included studies had a strength protocol design and all of them were conducted on humans. However, the most common limitations of them were the small sample size and the short time of the intervention. In conclusion, managing the factors that disrupt the optimal function of central and peripheral clocks can help to reduce the risk of metabolic and cardiovascular diseases, improving also sleep quality. Future studies should further explore the underlying mechanisms of the interconnections between circadian clocks and sleep, metabolic, and cardiovascular disorders. This may provide new opportunities for advance chronotherapy approach. |
| first_indexed | 2024-03-11T06:11:07Z |
| format | Article |
| id | doaj.art-28d38f85fb0842088905f68d9e4836f3 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T06:11:07Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-28d38f85fb0842088905f68d9e4836f32023-11-17T12:36:32ZengMDPI AGMetabolites2218-19892023-03-0113337010.3390/metabo13030370Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human StudiesMaria Mentzelou0Sousana K. Papadopoulou1Dimitrios Papandreou2Maria Spanoudaki3Antonios Dakanalis4Georgios K. Vasios5Gavriela Voulgaridou6Eleni Pavlidou7Maria Mantzorou8Constantinos Giaginis9Department of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Myrina, Lemnos, GreeceDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, GreeceDepartment of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi P.O. Box 144534, United Arab EmiratesDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, GreeceDepartment of Medicine and Surgery, University of Milano Bicocca, Via Cadore 38, 20900 Monza, ItalyDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Myrina, Lemnos, GreeceDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, GreeceDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Myrina, Lemnos, GreeceDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Myrina, Lemnos, GreeceDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Myrina, Lemnos, GreeceCircadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h rhythms in the body. Many metabolic, cellular, behavioral and physiological processes are regulated by the circadian clock in coordination with environmental cues. The present study is a comprehensive review of the currently existing evidence concerning the relationship between circadian rhythms and sleep, metabolic, and cardiovascular disorders. We thoroughly searched the online databases PubMed, Scopus, and Web of Science to find the existing clinical studies from the last twenty-three years (2000–2023). Circadian misalignment was found to be associated with an increase in the risk of metabolic disorders, cardiovascular diseases, and obesity, as well as inadequate sleep quality. In this review article, all the included studies had a strength protocol design and all of them were conducted on humans. However, the most common limitations of them were the small sample size and the short time of the intervention. In conclusion, managing the factors that disrupt the optimal function of central and peripheral clocks can help to reduce the risk of metabolic and cardiovascular diseases, improving also sleep quality. Future studies should further explore the underlying mechanisms of the interconnections between circadian clocks and sleep, metabolic, and cardiovascular disorders. This may provide new opportunities for advance chronotherapy approach.https://www.mdpi.com/2218-1989/13/3/370circadian rhythmsmetabolic disorderscardiovascular diseasesobesitydiabetes mellitussleep quality |
| spellingShingle | Maria Mentzelou Sousana K. Papadopoulou Dimitrios Papandreou Maria Spanoudaki Antonios Dakanalis Georgios K. Vasios Gavriela Voulgaridou Eleni Pavlidou Maria Mantzorou Constantinos Giaginis Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies Metabolites circadian rhythms metabolic disorders cardiovascular diseases obesity diabetes mellitus sleep quality |
| title | Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies |
| title_full | Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies |
| title_fullStr | Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies |
| title_full_unstemmed | Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies |
| title_short | Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies |
| title_sort | evaluating the relationship between circadian rhythms and sleep metabolic and cardiovascular disorders current clinical evidence in human studies |
| topic | circadian rhythms metabolic disorders cardiovascular diseases obesity diabetes mellitus sleep quality |
| url | https://www.mdpi.com/2218-1989/13/3/370 |
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