Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic Review
Collagen is a key component of the extracellular matrix (ECM) in organs and tissues throughout the body and is used for many tissue engineering applications. Electrospinning of collagen can produce scaffolds in a wide variety of shapes, fiber diameters and porosities to match that of the native ECM....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/8/3/39 |
| _version_ | 1827697327119269888 |
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| author | Britani N. Blackstone Summer C. Gallentine Heather M. Powell |
| author_facet | Britani N. Blackstone Summer C. Gallentine Heather M. Powell |
| author_sort | Britani N. Blackstone |
| collection | DOAJ |
| description | Collagen is a key component of the extracellular matrix (ECM) in organs and tissues throughout the body and is used for many tissue engineering applications. Electrospinning of collagen can produce scaffolds in a wide variety of shapes, fiber diameters and porosities to match that of the native ECM. This systematic review aims to pool data from available manuscripts on electrospun collagen and tissue engineering to provide insight into the connection between source material, solvent, crosslinking method and functional outcomes. D-banding was most often observed in electrospun collagen formed using collagen type I isolated from calfskin, often isolated within the laboratory, with short solution solubilization times. All physical and chemical methods of crosslinking utilized imparted resistance to degradation and increased strength. Cytotoxicity was observed at high concentrations of crosslinking agents and when abbreviated rinsing protocols were utilized. Collagen and collagen-based scaffolds were capable of forming engineered tissues in vitro and in vivo with high similarity to the native structures. |
| first_indexed | 2024-03-10T13:07:30Z |
| format | Article |
| id | doaj.art-28d44681a4a84676b9d6e8e30ed8bc70 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T13:07:30Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-28d44681a4a84676b9d6e8e30ed8bc702023-11-21T10:58:54ZengMDPI AGBioengineering2306-53542021-03-01833910.3390/bioengineering8030039Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic ReviewBritani N. Blackstone0Summer C. Gallentine1Heather M. Powell2Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USADepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USADepartment of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USACollagen is a key component of the extracellular matrix (ECM) in organs and tissues throughout the body and is used for many tissue engineering applications. Electrospinning of collagen can produce scaffolds in a wide variety of shapes, fiber diameters and porosities to match that of the native ECM. This systematic review aims to pool data from available manuscripts on electrospun collagen and tissue engineering to provide insight into the connection between source material, solvent, crosslinking method and functional outcomes. D-banding was most often observed in electrospun collagen formed using collagen type I isolated from calfskin, often isolated within the laboratory, with short solution solubilization times. All physical and chemical methods of crosslinking utilized imparted resistance to degradation and increased strength. Cytotoxicity was observed at high concentrations of crosslinking agents and when abbreviated rinsing protocols were utilized. Collagen and collagen-based scaffolds were capable of forming engineered tissues in vitro and in vivo with high similarity to the native structures.https://www.mdpi.com/2306-5354/8/3/39collagenelectrospinningtissue engineering |
| spellingShingle | Britani N. Blackstone Summer C. Gallentine Heather M. Powell Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic Review Bioengineering collagen electrospinning tissue engineering |
| title | Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic Review |
| title_full | Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic Review |
| title_fullStr | Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic Review |
| title_full_unstemmed | Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic Review |
| title_short | Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic Review |
| title_sort | collagen based electrospun materials for tissue engineering a systematic review |
| topic | collagen electrospinning tissue engineering |
| url | https://www.mdpi.com/2306-5354/8/3/39 |
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