Missing observations in regression: a conditional approach

This note presents an alternative to multiple imputation and other approaches to regression analysis in the presence of missing covariate data. Our recommendation, based on factorial and fractional factorial arrangements, is more faithful to ancillarity considerations of regression analysis and invo...

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Main Authors: H. S. Battey, D. R. Cox
Format: Article
Language:English
Published: The Royal Society 2023-02-01
Series:Royal Society Open Science
Subjects:
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsos.220267
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author H. S. Battey
D. R. Cox
author_facet H. S. Battey
D. R. Cox
author_sort H. S. Battey
collection DOAJ
description This note presents an alternative to multiple imputation and other approaches to regression analysis in the presence of missing covariate data. Our recommendation, based on factorial and fractional factorial arrangements, is more faithful to ancillarity considerations of regression analysis and involves assessing the sensitivity of inference on each regression parameter to missingness in each of the explanatory variables. The ideas are illustrated on a medical example concerned with the success of hematopoietic stem cell transplantation in children, and on a sociological example concerned with socio-economic inequalities in educational attainment.
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spelling doaj.art-28d4614a4a924eff889c4d293de6521d2023-03-28T08:51:00ZengThe Royal SocietyRoyal Society Open Science2054-57032023-02-0110210.1098/rsos.220267Missing observations in regression: a conditional approachH. S. Battey0D. R. Cox1Department of Mathematics, Imperial College London, London SW7 2AZ, UKNuffield College, University of Oxford, Oxford OX1 1NF, UKThis note presents an alternative to multiple imputation and other approaches to regression analysis in the presence of missing covariate data. Our recommendation, based on factorial and fractional factorial arrangements, is more faithful to ancillarity considerations of regression analysis and involves assessing the sensitivity of inference on each regression parameter to missingness in each of the explanatory variables. The ideas are illustrated on a medical example concerned with the success of hematopoietic stem cell transplantation in children, and on a sociological example concerned with socio-economic inequalities in educational attainment.https://royalsocietypublishing.org/doi/10.1098/rsos.220267ancillarityEM algorithmfractional factorialHadamard matrixmissing dataregression
spellingShingle H. S. Battey
D. R. Cox
Missing observations in regression: a conditional approach
Royal Society Open Science
ancillarity
EM algorithm
fractional factorial
Hadamard matrix
missing data
regression
title Missing observations in regression: a conditional approach
title_full Missing observations in regression: a conditional approach
title_fullStr Missing observations in regression: a conditional approach
title_full_unstemmed Missing observations in regression: a conditional approach
title_short Missing observations in regression: a conditional approach
title_sort missing observations in regression a conditional approach
topic ancillarity
EM algorithm
fractional factorial
Hadamard matrix
missing data
regression
url https://royalsocietypublishing.org/doi/10.1098/rsos.220267
work_keys_str_mv AT hsbattey missingobservationsinregressionaconditionalapproach
AT drcox missingobservationsinregressionaconditionalapproach