Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects

Acid-sensing ion channels (ASICs) are voltage-independent H<sup>+</sup>-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers to form functional channels with hi...

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Bibliographic Details
Main Authors: Clément Verkest, Miguel Salinas, Sylvie Diochot, Emmanuel Deval, Eric Lingueglia, Anne Baron
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Toxins
Subjects:
ASIC
sodium channels
toxins
peptide
PcTx1
APETx2
Online Access:https://www.mdpi.com/2072-6651/14/10/709

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